메뉴 건너뛰기




Volumn 35, Issue 10, 2005, Pages 2826-2839

Melanoma cell necrosis facilitates transfer of specific sets of antigens onto MHC class II molecules of dendritic cells

Author keywords

Antigen presentation; Heat shock proteins; T helper cells; Tumor antigens; Vaccines

Indexed keywords

DENDRITIC CELL VACCINE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 73; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 27644535766     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200526299     Document Type: Article
Times cited : (8)

References (53)
  • 1
    • 0035219802 scopus 로고    scopus 로고
    • Autologous dendritic cells for treatment of advanced cancer - An update
    • Schadendorf, D. and Nestle, F. O., Autologous dendritic cells for treatment of advanced cancer - an update. Recent Results Cancer Res. 2001. 158: 236-248.
    • (2001) Recent Results Cancer Res. , vol.158 , pp. 236-248
    • Schadendorf, D.1    Nestle, F.O.2
  • 2
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • Rosenberg, S. A., Progress in human tumour immunology and immunotherapy. Nature 2001. 411: 380-384.
    • (2001) Nature , vol.411 , pp. 380-384
    • Rosenberg, S.A.1
  • 3
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert, M. L., Sauter, B. and Bhardwaj, N., Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998. 392: 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 4
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci, S., Lolkema, M. and Matzinger, P., Natural adjuvants: Endogenous activators of dendritic cells. Nat. Med. 1999. 5: 1249-1255.
    • (1999) Nat. Med. , vol.5 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 5
    • 0035890823 scopus 로고    scopus 로고
    • Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization
    • Kotera, Y., Shimizu, K. and Mule, J. J., Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization. Cancer Res. 2001. 61: 8105-8109.
    • (2001) Cancer Res. , vol.61 , pp. 8105-8109
    • Kotera, Y.1    Shimizu, K.2    Mule, J.J.3
  • 6
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • Sauter, B., Albert, M. L., Francisco, L., Larsson, M., Somersan, S. and Bhardwaj, N., Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 2000. 191: 423-434.
    • (2000) J. Exp. Med. , vol.191 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 8
    • 0034292406 scopus 로고    scopus 로고
    • Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses
    • Nouri-Shirazi, M., Banchereau, J., Bell, D., Burkeholder, S., Kraus, E. T., Davoust, J. and Palucka, K. A., Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. J. Immunol. 2000. 165: 3797-3803.
    • (2000) J. Immunol. , vol.165 , pp. 3797-3803
    • Nouri-Shirazi, M.1    Banchereau, J.2    Bell, D.3    Burkeholder, S.4    Kraus, E.T.5    Davoust, J.6    Palucka, K.A.7
  • 9
    • 0034919646 scopus 로고    scopus 로고
    • + T cells in antitumor immunity
    • + T cells in antitumor immunity. Trends Immunol. 2001. 22: 269-276.
    • (2001) Trends Immunol. , vol.22 , pp. 269-276
    • Wang, R.F.1
  • 10
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 11
    • 0029148878 scopus 로고
    • Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
    • Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A., Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products. J. Exp. Med. 1995. 182: 389-400.
    • (1995) J. Exp. Med. , vol.182 , pp. 389-400
    • Sallusto, F.1    Cella, M.2    Danieli, C.3    Lanzavecchia, A.4
  • 12
    • 0030858138 scopus 로고    scopus 로고
    • Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
    • Cella, M., Engering, A., Pinet, V., Pieters, J. and Lanzavecchia, A., Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 1997. 388: 782-787.
    • (1997) Nature , vol.388 , pp. 782-787
    • Cella, M.1    Engering, A.2    Pinet, V.3    Pieters, J.4    Lanzavecchia, A.5
  • 14
    • 0034927975 scopus 로고    scopus 로고
    • Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
    • Kaisho, T. and Akira, S., Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol. 2001. 22: 78-83.
    • (2001) Trends Immunol. , vol.22 , pp. 78-83
    • Kaisho, T.1    Akira, S.2
  • 16
    • 0037089529 scopus 로고    scopus 로고
    • Apoptotic pancreatic tumor cells are superior to cell lysates in promoting cross-priming of cytotoxic T cells and activate NK and gammadelta T cells
    • Schnurr, M., Scholz, C., Rothenfusser, S., Galambos, P., Dauer, M., Robe, J., Endres, S. and Eigler, A., Apoptotic pancreatic tumor cells are superior to cell lysates in promoting cross-priming of cytotoxic T cells and activate NK and gammadelta T cells. Cancer Res. 2002. 62: 2347-2352.
    • (2002) Cancer Res. , vol.62 , pp. 2347-2352
    • Schnurr, M.1    Scholz, C.2    Rothenfusser, S.3    Galambos, P.4    Dauer, M.5    Robe, J.6    Endres, S.7    Eigler, A.8
  • 17
    • 0033747044 scopus 로고    scopus 로고
    • Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway
    • Basu, S., Binder, R. J., Suto, R., Anderson, K. M. and Srivastava, P. K., Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int. Immunol. 2000. 12: 1539-1546.
    • (2000) Int. Immunol. , vol.12 , pp. 1539-1546
    • Basu, S.1    Binder, R.J.2    Suto, R.3    Anderson, K.M.4    Srivastava, P.K.5
  • 18
    • 0035877850 scopus 로고    scopus 로고
    • Vitally induced lytic cell death elicits the release of immunogenic GRP94/gp96
    • Berwin, B., Reed, R. C. and Nicchitta, C. V., Vitally induced lytic cell death elicits the release of immunogenic GRP94/gp96. J. Biol. Chem. 2001. 276: 21083-21088.
    • (2001) J. Biol. Chem. , vol.276 , pp. 21083-21088
    • Berwin, B.1    Reed, R.C.2    Nicchitta, C.V.3
  • 19
    • 0035500779 scopus 로고    scopus 로고
    • Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells
    • Somersan, S., Larsson, M., Fonteneau, J. F., Basu, S., Srivastava, P. and Bhardwaj, N., Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells. J. Immunol. 2001. 167: 4844-4852.
    • (2001) J. Immunol. , vol.167 , pp. 4844-4852
    • Somersan, S.1    Larsson, M.2    Fonteneau, J.F.3    Basu, S.4    Srivastava, P.5    Bhardwaj, N.6
  • 20
    • 0034252620 scopus 로고    scopus 로고
    • CD91: A receptor for heat shock protein gp96
    • Binder, R. J., Han, D. K. and Srivastava, P. K., CD91: A receptor for heat shock protein gp96. Nat. Immunol. 2000. 1: 151-155.
    • (2000) Nat. Immunol. , vol.1 , pp. 151-155
    • Binder, R.J.1    Han, D.K.2    Srivastava, P.K.3
  • 21
    • 0037144808 scopus 로고    scopus 로고
    • CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes
    • Becker, T., Hartl, F. U. and Wieland, F., CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J. Cell Biol. 2002. 158: 1277-1285.
    • (2002) J. Cell Biol. , vol.158 , pp. 1277-1285
    • Becker, T.1    Hartl, F.U.2    Wieland, F.3
  • 22
    • 0034614886 scopus 로고    scopus 로고
    • The induction of tolerance by dendritic cells that have captured apoptotic cells
    • Steinman, R. M., Turley, S., Mellman, I. and Inaba, K., The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 2000. 191: 411-416.
    • (2000) J. Exp. Med. , vol.191 , pp. 411-416
    • Steinman, R.M.1    Turley, S.2    Mellman, I.3    Inaba, K.4
  • 23
    • 0035728468 scopus 로고    scopus 로고
    • Apoptosis: The quiet death silences the immune system
    • Sun, E. W. and Shi, Y. F., Apoptosis: the quiet death silences the immune system. Pharmacol. Ther. 2001. 92: 135-145.
    • (2001) Pharmacol. Ther. , vol.92 , pp. 135-145
    • Sun, E.W.1    Shi, Y.F.2
  • 24
    • 0034918104 scopus 로고    scopus 로고
    • Dendritic cells: On the move from bench to bedside
    • Nestle, F. O., Banchereau, J. and Hart, D., Dendritic cells: On the move from bench to bedside. Nat. Med. 2001. 7: 761-765.
    • (2001) Nat. Med. , vol.7 , pp. 761-765
    • Nestle, F.O.1    Banchereau, J.2    Hart, D.3
  • 25
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V. et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 1993. 90: 3539-3543.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3    Golumbek, P.4    Levitsky, H.5    Brose, K.6    Jackson, V.7
  • 26
    • 0031890206 scopus 로고    scopus 로고
    • Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
    • Rosenberg, S. A., Yang, J. C., Schwartzentruber, D. J., Hwu, P., Marincola, F. M., Topalian, S. L., Restifo, N. P. et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat. Med. 1998. 4: 321-327.
    • (1998) Nat. Med. , vol.4 , pp. 321-327
    • Rosenberg, S.A.1    Yang, J.C.2    Schwartzentruber, D.J.3    Hwu, P.4    Marincola, F.M.5    Topalian, S.L.6    Restifo, N.P.7
  • 28
    • 0033405438 scopus 로고    scopus 로고
    • Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
    • Thurner, B., Haendle, I., Roder, C., Dieckmann, D., Keikavoussi, P., Jonuleit, H., Bender, A. et al. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J. Exp. Med. 1999. 190: 1669-1678.
    • (1999) J. Exp. Med. , vol.190 , pp. 1669-1678
    • Thurner, B.1    Haendle, I.2    Roder, C.3    Dieckmann, D.4    Keikavoussi, P.5    Jonuleit, H.6    Bender, A.7
  • 29
    • 0033056073 scopus 로고    scopus 로고
    • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
    • Lee, P. P., Yee, C., Savage, P. A., Fong, L., Brockstedt, D., Weber, J. S., Johnson, D. et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med. 1999. 5: 677-685.
    • (1999) Nat. Med. , vol.5 , pp. 677-685
    • Lee, P.P.1    Yee, C.2    Savage, P.A.3    Fong, L.4    Brockstedt, D.5    Weber, J.S.6    Johnson, D.7
  • 32
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R. and Melief, C. J., T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998. 393: 480-483.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    van der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 33
    • 0033964149 scopus 로고    scopus 로고
    • Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells
    • Salio, M., Cerundolo, V. and Lanzavecchia, A., Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells. Eur. J. Immunol 2000. 30: 705-708.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 705-708
    • Salio, M.1    Cerundolo, V.2    Lanzavecchia, A.3
  • 35
    • 0031914912 scopus 로고    scopus 로고
    • Human monoclonal antibody with T cell-like specificity recognizes MHC class I self-peptide presented by HLA-DR1 on activated cells
    • Wolpl, A., Halder, T., Kalbacher, H., Neumeyer, H., Siemoneit, K., Goldmann, S. F. and Eiermann, T. H., Human monoclonal antibody with T cell-like specificity recognizes MHC class I self-peptide presented by HLA-DR1 on activated cells. Tissue Antigens 1998. 51: 258-269.
    • (1998) Tissue Antigens , vol.51 , pp. 258-269
    • Wolpl, A.1    Halder, T.2    Kalbacher, H.3    Neumeyer, H.4    Siemoneit, K.5    Goldmann, S.F.6    Eiermann, T.H.7
  • 37
    • 0037928705 scopus 로고    scopus 로고
    • Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages
    • Gao, B. and Tsan, M. F., Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages. J. Biol. Chem. 2003. 278: 22523-22529.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22523-22529
    • Gao, B.1    Tsan, M.F.2
  • 38
    • 0032101221 scopus 로고    scopus 로고
    • Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
    • Srivastava, P. K., Menoret, A., Basu, S., Binder, R. J. and McQuade, K. L., Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world. Immunity 1998. 8: 657-665.
    • (1998) Immunity , vol.8 , pp. 657-665
    • Srivastava, P.K.1    Menoret, A.2    Basu, S.3    Binder, R.J.4    McQuade, K.L.5
  • 39
    • 0037108696 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: Clinical and immunologic findings
    • Belli, F., Testori, A., Rivoltini, L., Maio, M., Andreola, G., Sertoli, M. R., Gallino, G. et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: Clinical and immunologic findings. J. Clin. Oncol. 2002. 20: 4169-4180.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4169-4180
    • Belli, F.1    Testori, A.2    Rivoltini, L.3    Maio, M.4    Andreola, G.5    Sertoli, M.R.6    Gallino, G.7
  • 40
    • 0027181070 scopus 로고
    • Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
    • Chicz, R. M., Urban, R. G., Gorga, J. C., Vignali, D. A., Lane, W. S. and Strominger, J. L., Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 1993. 178: 27-47.
    • (1993) J. Exp. Med. , vol.178 , pp. 27-47
    • Chicz, R.M.1    Urban, R.G.2    Gorga, J.C.3    Vignali, D.A.4    Lane, W.S.5    Strominger, J.L.6
  • 41
    • 0035383790 scopus 로고    scopus 로고
    • Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity
    • Feng, H., Zeng, Y., Whitesell, L. and Katsanis, E., Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity. Blood 2001. 97: 3505-3512.
    • (2001) Blood , vol.97 , pp. 3505-3512
    • Feng, H.1    Zeng, Y.2    Whitesell, L.3    Katsanis, E.4
  • 42
    • 0036688917 scopus 로고    scopus 로고
    • mRNA expression of tumor-associated antigens in melanoma tissues and cell lines
    • Eichmuller, S., Usener, D., Jochim, A. and Schadendorf, D., mRNA expression of tumor-associated antigens in melanoma tissues and cell lines. Exp. Dermatol. 2002. 11: 292-301.
    • (2002) Exp. Dermatol. , vol.11 , pp. 292-301
    • Eichmuller, S.1    Usener, D.2    Jochim, A.3    Schadendorf, D.4
  • 43
    • 0019395093 scopus 로고
    • Distinct lung-colonizing and lung-metastasizing cell populations in B16 mouse melanoma
    • Stackpole, C. W., Distinct lung-colonizing and lung-metastasizing cell populations in B16 mouse melanoma. Nature 1981. 289: 798-800.
    • (1981) Nature , vol.289 , pp. 798-800
    • Stackpole, C.W.1
  • 44
    • 0022718930 scopus 로고
    • Impaired assembly and transport of HLA-A and -B antigens in a mutant T × B cell hybrid
    • Salter, R. D. and Cresswell, P., Impaired assembly and transport of HLA-A and -B antigens in a mutant T × B cell hybrid. EMBO J. 1986. 5: 943-949.
    • (1986) EMBO J. , vol.5 , pp. 943-949
    • Salter, R.D.1    Cresswell, P.2
  • 45
    • 0031690656 scopus 로고    scopus 로고
    • Tumour-specific MHC-class-II-restricted responses after in vitro sensitization to synthetic peptides corresponding to gp100 and annexin II eluted from melanoma cells
    • Li, K., Adibzadeh, M., Halder, T., Kalbacher, H., Heinzel, S., Muller, C., Zeuthen, J. and Pawelec, G., Tumour-specific MHC-class-II-restricted responses after in vitro sensitization to synthetic peptides corresponding to gp100 and annexin II eluted from melanoma cells. Cancer Immunol. Immunother. 1998. 47: 32-38.
    • (1998) Cancer Immunol. Immunother. , vol.47 , pp. 32-38
    • Li, K.1    Adibzadeh, M.2    Halder, T.3    Kalbacher, H.4    Heinzel, S.5    Muller, C.6    Zeuthen, J.7    Pawelec, G.8
  • 46
    • 0028302028 scopus 로고
    • Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes
    • Kawakami, Y., Eliyahu, S., Sakaguchi, K., Robbins, P. F., Rivoltini, L., Yannelli, J. R., Appella, E. and Rosenberg, S. A., Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J. Exp. Med. 1994. 180: 347-352.
    • (1994) J. Exp. Med. , vol.180 , pp. 347-352
    • Kawakami, Y.1    Eliyahu, S.2    Sakaguchi, K.3    Robbins, P.F.4    Rivoltini, L.5    Yannelli, J.R.6    Appella, E.7    Rosenberg, S.A.8
  • 47
    • 0026609981 scopus 로고
    • DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles
    • Sidney, J., Oseroff, C., Southwood, S., Wall, M., Ishioka, G., Koning, F. and Sette, A., DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles. J. Immunol. 1992. 149: 2634-2640.
    • (1992) J. Immunol. , vol.149 , pp. 2634-2640
    • Sidney, J.1    Oseroff, C.2    Southwood, S.3    Wall, M.4    Ishioka, G.5    Koning, F.6    Sette, A.7
  • 51
    • 0033034158 scopus 로고    scopus 로고
    • Identification of destabilizing residues in HLA class II-selected bacteriophage display libraries edited by HLA-DM
    • Raddrizzard, L., Bono, E., Vogt, A. B., Kropshofer, H., Gallazzi, F., Sturniolo, T., Hammerling, G. J. et al. Identification of destabilizing residues in HLA class II-selected bacteriophage display libraries edited by HLA-DM. Eur. J. Immunol. 1999. 29: 660-668.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 660-668
    • Raddrizzard, L.1    Bono, E.2    Vogt, A.B.3    Kropshofer, H.4    Gallazzi, F.5    Sturniolo, T.6    Hammerling, G.J.7
  • 53
    • 0037093234 scopus 로고    scopus 로고
    • Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells
    • Sun, Y., Sijts, A. J., Song, M., Janek, K., Nussbaum, A. K., Kral, S., Schirle, M. et al. Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Res. 2002. 62: 2875-2882.
    • (2002) Cancer Res. , vol.62 , pp. 2875-2882
    • Sun, Y.1    Sijts, A.J.2    Song, M.3    Janek, K.4    Nussbaum, A.K.5    Kral, S.6    Schirle, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.