Spontaneous activation of pancreas trypsinogen in heat shock protein 70.1 knock-out mice

Pancreas

Volumn 31, Issue 4, 2005, Pages 332-336

  Hwang, Jin Hyeok ^b   Ryu, Ji Kon ^b   Yoon, Yong Bum ^b   Lee, Kwang Hyuck ^a   Park, Young Soo ^a   Kim, Jin Wook ^a   Kim, Nayoung ^a   Lee, Dong Ho ^a   Jeong, Ji Bong ^c   Seo, Jeong Sun ^b   Kim, Yong Tae ^a,b  

^a Seoul National University Bundang Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Seoul National University Boramae Hospital   (South Korea)

Author keywords

Acute pancreatitis; Cathepsin B; Cerulein; Heat shock protein 70; Knock out; Trypsin

Indexed keywords

CATHEPSIN B; ENZYME PRECURSOR; HEAT SHOCK PROTEIN 70; LYSOSOME ENZYME; TRYPSIN; TRYPSINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DISEASE MODEL; EDEMA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE EXPRESSION; HISTOLOGY; HYPERTHERMIA; KNOCKOUT MOUSE; LYSOSOME; MOUSE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CATHEPSIN B; ENZYME ACTIVATION; FEVER; HSP70 HEAT-SHOCK PROTEINS; MICE; MICE, KNOCKOUT; PANCREAS; PANCREATITIS; TRYPSINOGEN;

EID: 27644502430     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000183377.04295.c3     Document Type: Article

References (24)

1. Ritassa FA. A new puffing pattern induced by temperature shock and DNP in Drosophila. Experientia. 1962;18:571-573.
2. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther. 1998;80:183-20l.
3. Lindquist S. The heat-shock response. Annu Rev Biochem. 1986;55:1151-1191.
4. Leppa S, Sistonen L. Heat shock response-pathophysiological implications. Ann Med. 1997;29:73-78.
5. Wagner AC, Weber H, Jonas L, et al. Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats. Gastroenterology. 1996;111:1333-1342.
6. Metzler W, Hofken T, Weber H, et al. Hyperthermia, inducing pancreatic heat-shock proteins, fails to prevent cerulein-induced stress kinase activation. Pancreas. 1999;19:150-157.
7. Grise K, Kim F, Mcfadden D. Hyperthermia induces heat-shock protein expression, reduces pancreatic injury, and improves survival in necrotizing pancreatitis. Pancreas. 2000;21:120-125.
8. Weber H, Wagner AC, Jonas L, et al. Heat shock response is associated with protection against acute interstitial pancreatitis in rats. Dig Dis Sci. 2000;45:2252-2264.
9. Frossard JL, Bhagat L, Lee HS, et al. Both thermal and non-thermal stress protect against cerulein induced pancreatitis and prevent trypsinogen activation in the pancreas. Gut. 2002;50:78-83.
10. Bhagat L, Singh VP, Song AM, et al. Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats. Gastroenterology. 2002;122:156-165.
11. Lee HS, Bhagat L, Frossard JL, et al. Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats. Gastroenterology. 2000;119:220-229.
12. Bhagat L, Singh VP, Hietaranta AJ, et al. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation. J Clin Invest. 2000;106:81-89.
13. Rakonczay Z Jr, Takacs T, Boros I, et al. Heat shock proteins and the pancreas. J Cell Physiol. 2003;195:383-391.
14. Otaka M, Okuyama A, Otani S, et al. Differential induction of Hsp60 and Hsp70 by different stress situation in rats: correlation with cerulein-induced pancreatitis. Dig Dis Sci. 1997;42:1473-1479.
15. Kwon SB, Young C, Kim DS, et al. Impaired repair ability of hsp70.1 KO mouse after UVB irradiation. J Dermatol Sci. 2002;28:144-151.
16. Kawabata S, Miura T, Monta T, et al. Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin. Eur J Biochem. 1988;172:17-25.
17. Labarca C, Paigen K. A simple, rapid and sensitive DNA assay procedure. Anal Biochem. 1980;102:344-352.
18. McDonald JK, Ellis S. On the substrate specificity of cathepsin B1 and B2 including a new fluorogenic substrate for cathepsin B1. Life Sci. 1975;17:1269-1276.
19. Dix DJ, Garges JB, Hong RL. Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic. Mol Reprod Dev. 1998;51:373-380.
20. Ethridge RT, Ehlers RA, Hellmich MR, et al. Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1. Pancreas. 2000;21:248-256.
21. Weber CK, Gress T, Muller-Pillasch F, et al. Supramaximal secretagogue stimulation enhances heat shock protein expression in the rat pancreas. Pancreas. 1995;10:360-367.
22. Strowski MZ, Sparmann G, Weber H, et al. Cerulein pancreatitis increases mRNA but reduces protein levels of rat pancreatic heat shock proteins. Am J Physiol. 1997;273:G937-G945.
23. Grady T, Mah'moud M, Otani T, et al. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am J Physiol. 1998;275:G1010-G1017.
24. Halangk W, Lerch MM, Brandt-Nedelev B, et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest. 2000;106:773-781.