Metabolism and action of α- and β-thujone;Stoffwechsel und wirkung der α- und β-thujone

Ernahrungs Umschau

Volumn 52, Issue 10, 2005, Pages

  Schmandke, Horst ^a  

^a NONE   (Germany)

Author keywords

thujone; thujone; Metabolism

Indexed keywords

2 HYDROXYTHUJONE; 3 HYDROXYTHUJAN; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 HYDROXYTHUJONE; 7 HYDROXYTHUJONE; ABSINTHOL; BETA THUYONE; CYTOCHROME P450; DEHYDROTHUJONE; ESSENTIAL OIL; TERPENOID; UNCLASSIFIED DRUG;

ABSINTHE; ALCOHOLIC BEVERAGE; BEVERAGE; CONVULSION; FOOD; FOOD POISONING; GLUCURONIDATION; HUMAN; HYDROXYLATION; METABOLISM; METABOLITE; NEUROTOXICITY; NONHUMAN; REVIEW; SPICE; SPINAL GANGLION; URINARY EXCRETION;

ARTEMISIA; JUNIPERUS; ROSMARINUS OFFICINALIS; SALVIA SCLAREA; TANACETUM VULGARE; THYMUS VULGARIS;

EID: 27644466590     PISSN: 01740008     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (11)

1. European Commission, Health and Consumer Protection: Opinion of the Scientific Committee on Food on Thujone, Brüssel, 6. Februar 2003, S. 4
2. Lang M, Fauhl C, Wittkowski R: Belastungssituation von Absinth mit Thujon. BGVV-Hefte 8, 34 (2002)
3. Alaoui MI, Benjilali B, Azerad R: Biotransformation of terpenic compounds by fungi. II. Metabolism of α-(-)-thujone. Natural Product Lett 4, 263-266 (1994)
4. Ishida T, Toyota M, Asakawa Y: Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (+-)-7-hydroxycitronellal, citral, (-)-perillaldehyde, (-)-myrtenal, cuminaldehyde, thujone and (+)-carvone in rabbits. Xenobiotica 19, 843-855 (1989)
5. Hold KM, Sirisoma NS, Ikeda T, Narahashi T, Casida JE: α-Thujone (the active component of absinthe): γ-Aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci 97, 3826-3831 (2000)
6. Hold KM, Sirisoma NS, Casida JE: Detoxification of α and β-thujones (the active ingredients of absinthe): Site specifity and species differences in cytochrome P450 oxidation in vitro and in vivo. Chem Res Toxicol 14, 589-595 (2001)
7. Rice KC, Wilson RS: (-)-3-Isotujone, a small nonnitrogenous molecule with antinociceptive activity in mice. J Med Chem 19, 1054-1057 (1976)
8. National Library of Medicine: Registry of toxic effects of chemical substances. Bethesda (MD) 1997
9. Council of Europe, 1999. Document RD 4.2 / 14-44. Revised detailed datasheet on thujone
10. Council Directive 88 / 388 / EEC of 21 June 1988 on the approximation of the laws of the Member States relating to flavourings for use in foodstuffs and to source materials for their production. Official Journal of the European Communities, 15.7.1988, L 184/61-72
11. Sirisoma NS, Hold KM, Casida JE: α- and β-Thujones (Herbal medicines and food additives): Synthesis and analysis of hydroxy and dehydro metabolites. J Agric Food Chem 49, 1915-1921 (2001)