Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M

Journal of Leukocyte Biology

Volumn 78, Issue 5, 2005, Pages 1081-1085

  Cole, Alexander M ^a,d   Thapa, Dharma R ^b,c   Gabayan, Victoria ^b,c   Liao, Hsiang I ^b,c   Liu, Lide ^b,c   Ganz, Tomas ^b,e  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Biomolecular Science Center   (United States)

^e Division of Pulmonary and Critical Care Medicine   (United States)

Author keywords

Bacteria; Knockout

Indexed keywords

LYSOZYME; LYSOZYME M; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; HOST RESISTANCE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUCOCILIARY CLEARANCE; MURAMIDASE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE; PSEUDOMONAS AERUGINOSA;

EID: 27644434474     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0205073     Document Type: Article

References (18)

1. Cole, A. M., Liao, H. I., Stuchlik, O., Tilan, J., Pohl, J., Ganz, T. (2002) Cationic polypeptides are required for antibacterial activity of human airway fluid. J. Immunol. 169, 6985-6991.
2. Akinbi, H. T., Epaud, R., Bhatt, H., Weaver, T. E. (2000) Bacterial killing is enhanced by expression of lysozyme in the lungs of transgenic mice. J. Immunol. 165, 5760-5766.
3. Ganz, T., Gabayan, V., Liao, H. I., Liu, L., Oren, A., Graf, T., Cole, A. M. (2002) Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan. Blood 101, 2388-2392.
4. Ibrahim, H. R., Matsuzaki, T., Aoki, T. (2001) Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function. FEBS Lett. 506, 27-32.
5. Wecke, J., Lahav, M., Ginsburg, I., Giesbreeht, P. (1982) Cell wall degradation of Staphylococcus aureus by lysozyme. Arch. Microbiol. 131, 116-123.
6. Laible, N. J., Germaine, G. R. (1985) Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides. Infect. Immun. 48, 720-728.
7. Ginsburg, I. (2004) Bactericidal cationic peptides can also function as bacteriolysis-inducing agents mimicking β-lactam antibiotics?; it is enigmatic why this concept is consistently disregarded. Med. Hypotheses 62, 367-374.
8. Markart, P., Korfhagen, T. R., Weaver, T. E., Akinbi, H. T. (2004) Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection. Am. J. Respir. Crit. Care Med. 169, 454-458.
9. Faust, N., Varas, F., Kelly, L. M., Heck, S., Graf, T. (2000) Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 96, 719-726.
10. Cole, A. M., Dewan, P., Ganz, T. (1999) Innate antimicrobial activity of nasal secretions. Infect. Immun. 67, 3267-3275.
11. Schagger, H., von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166, 368-379.
12. Valore, E. V., Park, C. H., Quayle, A. J., Wiles, K. R., McCray, P. B., Ganz, T. (1998) Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101, 1633-1642.
13. Valore, E. V., Ganz, T. (1997) Laboratory production of antimicrobial peptides in native conformation. In Antimicrobial Peptide Protocols, vol. 78 (W. M. Shafer, ed.), Totowa, NJ, Humana, 115-131.
14. Osserman, E. F., Lawlor, D. P. (1966) Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J. Exp. Med. 124, 921-952.
15. Lehrer, R. I., Rosenman, M., Harwig, S. S., Jackson, R., Eisenhauer, P. (1991) Ultrasensitive assays for endogenous antimicrobial polypeptides. J. Immunol. Methods 137, 167-173.
16. Cole, A. M., Ganz, T., Liese, A. M., Burdick, M. D., Liu, L., Stricter, R. M. (2001) Cutting edge: IFN-inducible ELR(-) CXC chemokines display defensin-like antimicrobial activity. J. Immunol. 167, 623-627.
17. Markart, P., Faust, N., Graf, T., Na, C. L., Weaver, T. E., Akinbi, H. T. (2004) Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P. Biochem. J. 380, 385-392.
18. Singh, P. K., Tack, B. F., McCray Jr., P. B., Welsh, M. J. (2000) Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L799-L805.