The escape of temperature-sensitive T antigen immortalized rat hepatocytes from conditional immortalization

Cell Transplantation

Volumn 14, Issue 7, 2005, Pages 507-517

  Kim, Byung Ho ^a,c   Han, Yo Seb ^a   Choe, Bong Keun ^a   Cho, Hyeseong ^b   Nam, Gi Deog ^a   Lee, Jin Woo ^a   Kim, Young Il ^a   Park, Jai Kyung ^a   Dong, Seok Ho ^a   Kim, Hyo Jong ^a   Chang, Young Woon ^a   Lee, Joung Il ^a   Chang, Rin ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Kyung Hee University College of Medicine   (South Korea)

Author keywords

Cell growth; Hepatocytes; Immortalization; T antigen independence; Temperature sensitive SV 40 large T antigen

Indexed keywords

PROTEIN P21; PROTEIN P53; TELOMERASE; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL PROLIFERATION; CHROMOSOME DAMAGE; CLONE; CONTROLLED STUDY; GENE INACTIVATION; LIVER CELL; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; RAT; TELOMERE; TEMPERATURE SENSITIVE MUTANT; WESTERN BLOTTING;

ANIMALIA;

EID: 27644434340     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000005783982864     Document Type: Article

References (26)

1. Bourre, F.; Sarasin, A. Targeted mutagenesis of SV40 DNA induced by UV light. Nature 305:68-70; 1983.
2. el-Deiry, W. S.; Tokino, T.; Velculescu, V. E.; Levy, D. B.; Parsons, R.; Trent, J. M.; Lin, D.; Mercer, W. E.; Kinzler, K. W.; Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825; 1993.
3. Fiers, W.; Contreras, R.; Haegemann, G.; Rogiers, R.; Van de Voorde, A.; Van Heuverswyn, H.; Van Herreweghe, J.; Volckaert, G.; Ysebaert, M. Complete nucleotide sequence of SV40 DNA. Nature 273:113-120; 1978.
4. Greider, C. W. Chromosome first aid. Cell 67:645-647; 1991.
5. Harvey, D. M.; Levine, A. J. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev. 5:2375-2385; 1991.
6. Jat, P. S.; Sharp, P. A. Cell lines established by a temperature- sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature. Mol. Cell. Biol. 9:1672-1681; 1989.
7. Kim, B. H.; Han, Y. S.; Dong, S. H.; Kim, H. J.; Chang, Y. W.; Lee, J. I.; Chang, R. Temporary amelioration of bilirubin conjugation defect in Gunn rats by transplanting conditionally immortalized hepatocytes. J. Gastroenterol. Hepatol. 17:690-696; 2002.
8. Kim, B. H.; Sung, S. R.; Choi, E. H.; Kim, Y. I.; Kim, K. J.; Dong, S. H.; Kim, H. J.; Chang, Y. W.; Lee, J. I.; Chang, R. Dedifferentiation of conditionally immortalized hepatocytes with long-term in vitro passage. Exp. Mol. Med. 32:29-37; 2000.
9. Kim, N. W.; Piatyszek, M. A.; Prowse, K. R.; Harley, C. B.; West, M. D.; Ho, P. L.; Coviello, G. M.; Wright, W. E.; Weinrich, S. L.; Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015; 1994.
10. Kobayashi, N.; Miyazaki, M.; Fukaya, K.; Inoue, Y.; Sakaguchi, M.; Noguchi, H.; Matsumura, T.; Watanabe, T.; Totsugawa, T.; Tanaka, N.; Namba, M. Treatment of surgically induced acute liver failure with transplantation of highly differentiated immortalized human hepatocytes. Cell Transplant. 9:733-735; 2000.
11. Kowalski-Saunders, P. W.; Winwood, P. J.; Arthur, M. J.; Wright, R. Reversible inhibition of albumin production by rat hepatocyte maintained on a laminin-rich gel (Engelbreth-Holm-Swarm) in response to secretory products of Kupffer cells and cytokines. Hepatology 16:733-741; 1992.
12. Levine, A. J. Tumor suppressor genes. Bioessays 12:60-66; 1990.
13. Miller, G. M.; Silverman, A. J.; Roberts, J. L.; Dong, K. W.; Gibson, M. Functional assessment of intrahypothalamic implants of immortalized gonadotropin-releasing hormone-secreting cells in female hypogonadal mice. Cell Transplant. 2:251-257; 1993.
14. Park, J. K.; Kim, B. H.; Han, Y. S.; Park, I. K. The effect of telomerase expression on the escape from M2 crisis in virus-transformed human retinal pigment epithelial cells. Exp. Mol. Med. 34:107-113; 2002.
15. Paul, D.; Hohne, M.; Pinkert, C.; Piasecki, A.; Ummelmann, E.; Brinster, R. L. Immortalized differentiated hepatocyte lines derived from transgenic mice harboring SV40 T-antigen genes. Exp. Cell Res. 175:354-362; 1988.
16. Sawada, N.; Lee, G. H.; Mochizuki, Y.; Ishikawa, T. Active proliferation of mouse hepatocytes in primary culture under defined conditions as compared to rat hepatocytes. Jpn. J. Cancer Res. 79:983-988; 1988.
17. Schippers, I. J.; Moshage, H.; Roelofsen, H.; Muller, M.; Heymans, H. S.; Ruiters, M.; Kuipers, F. Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation. Cell Biol. Toxicol. 13:375-386; 1997.
18. Seglen, P. O. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp. Cell Res. 82:391-398; 1973.
19. Stamps, A. C.; Gusterson, B. A.; O'Hare, M. J. Are tumours immortal? Eur. J. Cancer 28A:1495-1500; 1992.
20. Taher, A.; Yanai, N.; Obinata, M. Properties of incompletely immortalized cell lines generated from a line established from temperature-sensitive SV40 T-antigen gene transgenic mice. Exp. Cell Res. 219:332-338; 1995.
21. Truckenmiller, M. E.; Dillon-Carter, O.; Tornatore, C.; Kulaga, H.; Takashima, H.; Freed, W. J. Growth properties of neural cell lines immortalized with the tsA58 allele of SV40 large T antigen. Cell Transplant. 6:231-238; 1997.
22. Ulrich, E.; Boehmelt, G.; Bird, A.; Beug, H. Immortalization of conditionally transformed chicken cells: Loss of normal p53 expression is an early step that is independent of cell transformation. Genes Dev. 6:876-887; 1992.
23. Waldman, T.; Kinzler, K. W.; Vogelstein, B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55:5187-5190; 1995.
24. Waxman, D. J.; Morrissey, J. J.; Naik, S.; Jauregui, H. O. Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. Biochem. J. 271:113-119; 1990.
25. Wright, W. E.; Pereira-Smith, O. M.; Shay, J. W. Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts. Mol. Cell Biol. 9:3088-3092; 1989.
26. Yanai, N.; Obinata, M. Apoptosis is induced at nonpermissive temperature by a transient increase in p53 in cell lines immortalized with temperature-sensitive SV 40 large T-antigen gene. Exp. Cell Res. 211:296-300; 1994.