메뉴 건너뛰기




Volumn 24, Issue SUPPL. 4, 2005, Pages 5-11

Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L- proline and L-isoleucyl-L-prolyl-L-proline): II. Introduction

Author keywords

Food Ingredient; Generally Recognized as Safe (GRAS); IPP; Normotensive Effects; Tripeptides; VPP

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FOOD ADDITIVE; ISOLEUCYLPROLYLPROLINE; TRIPEPTIDE; UNCLASSIFIED DRUG; VALYLPROLYLPROLINE;

EID: 27544480832     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810500259531     Document Type: Review
Times cited : (17)

References (32)
  • 1
    • 27544452986 scopus 로고    scopus 로고
    • Studies of the lexicological potential of tripeptides (L-valy-L-prolyl-L-proline and L-isoleucyl-L-proplyl-L-proline): IX. Evaluation of the mutagentic potential of synthesized L-valyl-L-prolyl-L-proline in the Salmonella-Esherichia coli/microsome incorporation assay
    • Bernard, B. K., Y. Nakamura, K. Aihara, and J. H. Mennear. 2005. Studies of the lexicological potential of tripeptides (L-valy-L-prolyl-L-proline and L-isoleucyl-L-proplyl-L-proline): IX. Evaluation of the mutagentic potential of synthesized L-valyl-L-prolyl-L-proline in the Salmonella-Esherichia coli/microsome incorporation assay. Int. J. Toxicol. 24(Suppl. 4):107-113.
    • (2005) Int. J. Toxicol. , vol.24 , Issue.SUPPL. 4 , pp. 107-113
    • Bernard, B.K.1    Nakamura, Y.2    Aihara, K.3    Mennear, J.H.4
  • 2
    • 27544500418 scopus 로고    scopus 로고
    • In Japanese
    • Calpis Co., Ltd.: http://www.calpis.co.jp/images/000001200.pdf [In Japanese]
  • 3
    • 0029958113 scopus 로고    scopus 로고
    • A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects
    • Hata, Y., M. Yamamoto, M. Ohni, K. Kanajima, Y. Nakamura, and T. Takano. 1996. A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J. Clin. Nutr. 64:767-771.
    • (1996) Am J. Clin. Nutr. , vol.64 , pp. 767-771
    • Hata, Y.1    Yamamoto, M.2    Ohni, M.3    Kanajima, K.4    Nakamura, Y.5    Takano, T.6
  • 4
    • 27544491549 scopus 로고    scopus 로고
    • Clinical effects of new sour milk drink in mild or moderate hypertensive subjects.
    • In Japanese, English abstract
    • Hirata, H., Y. Nakamura, H. Yada, S. Moriguchi, O. Kajimoto, and T. Takahashi. 2002. Clinical effects of new sour milk drink in mild or moderate hypertensive subjects. [In Japanese, English abstract.] J. New Rem. Clin. 51:60-69.
    • (2002) J. New Rem. Clin. , vol.51 , pp. 60-69
    • Hirata, H.1    Nakamura, Y.2    Yada, H.3    Moriguchi, S.4    Kajimoto, O.5    Takahashi, T.6
  • 5
    • 0010373928 scopus 로고    scopus 로고
    • The effect of sour milk on blood pressure in untreated of hypertensive and normotensive subjects
    • Itakura, H., S. Ikemoto, S. Terada, and K. Kondo. 2001. The effect of sour milk on blood pressure in untreated of hypertensive and normotensive subjects. J. Jpn. Soc. Clin. Nutr. 23:26-31.
    • (2001) J. Jpn. Soc. Clin. Nutr. , vol.23 , pp. 26-31
    • Itakura, H.1    Ikemoto, S.2    Terada, S.3    Kondo, K.4
  • 6
    • 27544459666 scopus 로고    scopus 로고
    • Safety evaluation of excessive intake of the tablet containing "lactotripeptides (VPP, IPP)" in healthy volunteers
    • In Japanese, English abstract
    • Kajimoto, O., K. Aihara, H. Hirata, R. Takahashi, and Y. Nakamura. 2001a. Safety evaluation of excessive intake of the tablet containing "lactotripeptides (VPP, IPP)" in healthy volunteers. [In Japanese, English abstract.] J. Nutr. Food 4:37-46.
    • (2001) J. Nutr. Food , vol.4 , pp. 37-46
    • Kajimoto, O.1    Aihara, K.2    Hirata, H.3    Takahashi, R.4    Nakamura, Y.5
  • 7
    • 25444516491 scopus 로고    scopus 로고
    • Hypotensive effects of the tablets containing "lactotripeptides (VPP, IPP)"
    • In Japanese, English abstract
    • Kajimoto, O., K. Aihara, H. Hirata, R. Takahashi, and Y. Nakamura. 2001b. Hypotensive effects of the tablets containing "lactotripeptides (VPP, IPP)." [In Japanese, English abstract] J. Nutr Food 4:51-61.
    • (2001) J. Nutr. Food , vol.4 , pp. 51-61
    • Kajimoto, O.1    Aihara, K.2    Hirata, H.3    Takahashi, R.4    Nakamura, Y.5
  • 8
    • 27544474483 scopus 로고    scopus 로고
    • Antihypertensive effects of the liquid yogurt containing "lactotripeptides (VPP, IPP)" in mild hypertensive subjects
    • In Japanese, English abstract
    • Kajimoto, O., T. Kurosaki, J. Mizutani, N. Ikeda, K. Kaneko, M. Yabune, and Y. Nakamura. 2002. Antihypertensive effects of the liquid yogurt containing "lactotripeptides (VPP, IPP)" in mild hypertensive subjects. [In Japanese, English abstract.] J. Nutr. Food 5:55-66.
    • (2002) J. Nutr. Food , vol.5 , pp. 55-66
    • Kajimoto, O.1    Kurosaki, T.2    Mizutani, J.3    Ikeda, N.4    Kaneko, K.5    Yabune, M.6    Nakamura, Y.7
  • 9
    • 27544445154 scopus 로고    scopus 로고
    • Hypotensive effects of sour milk in subjects with mild or moderate hypotension
    • In Japanese, English abstract
    • Kajimoto, O., Y. Nakamura, H. Yada, S. Moriguchi, H. Hirata, and T. Takahashi. 2001c. Hypotensive effects of sour milk in subjects with mild or moderate hypotension. [In Japanese, English abstract.] J. Jap. Soc. Nutr. Food Sci. 54:347-354.
    • (2001) J. Jap. Soc. Nutr. Food Sci. , vol.54 , pp. 347-354
    • Kajimoto, O.1    Nakamura, Y.2    Yada, H.3    Moriguchi, S.4    Hirata, H.5    Takahashi, T.6
  • 10
    • 27544480393 scopus 로고    scopus 로고
    • Studies of the toxicological potential of tripeptides (L-valyl-L-proplyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VI. Effects of Lactobacillus helveticus-fermented milk powder on fertility and reproductive performance of rats
    • Kurosaki, T., M. Maeno, J. H. Mennear, and B. K. Bernard. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-proplyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VI. Effects of Lactobacillus helveticus-fermented milk powder on fertility and reproductive performance of rats. Int. J. Toxicol. 24(Suppl. 4):61-89.
    • (2005) Int. J. Toxicol. , vol.24 , Issue.SUPPL. 4 , pp. 61-89
    • Kurosaki, T.1    Maeno, M.2    Mennear, J.H.3    Bernard, B.K.4
  • 11
    • 27544511405 scopus 로고    scopus 로고
    • Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VIII. Assessment of cytotoxity and clastogenicity of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented milk powders in Chinese hamster lung cells
    • Maeno, M., S. Mizuno, J. H. Mennear, and B. K. Bernard. 2005a. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VIII. Assessment of cytotoxity and clastogenicity of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented milk powders in Chinese hamster lung cells. Int. J. Toxicol. 24(Suppl. 4):97-105.
    • (2005) Int. J. Toxicol. , vol.24 , Issue.SUPPL. 4 , pp. 97-105
    • Maeno, M.1    Mizuno, S.2    Mennear, J.H.3    Bernard, B.K.4
  • 12
    • 27544451219 scopus 로고    scopus 로고
    • Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): III. Single- and/or repeated-dose toxicity of tripeptides-containing Lactobacillus helveticus-fermented milk powder and casein hydrolysate in rats
    • Maeno, M., Y. Nakamura, J. H. Mennear, and B. K. Bernard. 2005b. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): III. Single- and/or repeated-dose toxicity of tripeptides-containing Lactobacillus helveticus-fermented milk powder and casein hydrolysate in rats. Int. J. Toxicol. 24(Suppl. 4):13-23.
    • (2005) Int. J. Toxicol. , vol.24 , Issue.SUPPL. 4 , pp. 13-23
    • Maeno, M.1    Nakamura, Y.2    Mennear, J.H.3    Bernard, B.K.4
  • 15
    • 27544497970 scopus 로고    scopus 로고
    • Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VII. Micronucleus test of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented milk powders in rats and mice
    • Matsuura, K., J. H. Mennear, M. Maeno, and B. K. Bernard. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VII. Micronucleus test of tripeptides- containing casein hydrolysate and Lactobacillus helveticus-fermented milk powders in rats and mice. Int. J. Toxicol. 24(Suppl. 4):91-96.
    • (2005) Int. J. Toxicol. , vol.24 , Issue.SUPPL. 4 , pp. 91-96
    • Matsuura, K.1    Mennear, J.H.2    Maeno, M.3    Bernard, B.K.4
  • 16
    • 27544458396 scopus 로고    scopus 로고
    • Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild-hypertension
    • Mizuno, S., K. Matsuura, T. Gotou, S. Nishimura, O. Kajimoto, M. Yabune, Y. Kajimoto, N. Yamamoto. 2005a. Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild-hypertension. Br. J. Nutr. 93:1-9.
    • (2005) Br. J. Nutr. , vol.93 , pp. 1-9
    • Mizuno, S.1    Matsuura, K.2    Gotou, T.3    Nishimura, S.4    Kajimoto, O.5    Yabune, M.6    Kajimoto, Y.7    Yamamoto, N.8
  • 17
    • 27544488043 scopus 로고    scopus 로고
    • Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): V. A 13-week toxicity study of tripeptides-containing casein hydrolysate in male and female rats
    • Mizuno, S., J. H. Mennear, K. Matsuura, and B. K. Bernard. 2005b. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): V. A 13-week toxicity study of tripeptides-containing casein hydrolysate in male and female rats. Int. J. Toxicol. 24(Suppl. 4):41-59.
    • (2005) Int. J. Toxicol. , vol.24 , Issue.SUPPL. 4 , pp. 41-59
    • Mizuno, S.1    Mennear, J.H.2    Matsuura, K.3    Bernard, B.K.4
  • 19
    • 27544445339 scopus 로고    scopus 로고
    • Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-Lprolyl-Lproline): IV. Assessment of the repeated-dose toxicological potential of synthesized L-valyl-L-prolyl-L- proline in male and female rats and dogs
    • Nakamura, Y., I. Bando, J. H. Mennear, and B. K. Bernard. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-Lprolyl-Lproline): IV. Assessment of the repeated-dose toxicological potential of synthesized L-valyl-L-prolyl-L-proline in male and female rats and dogs. Int. J. Toxicol. 24(Suppl. 4):25-39.
    • (2005) Int. J. Toxicol. , vol.24 , Issue.SUPPL. 4 , pp. 25-39
    • Nakamura, Y.1    Bando, I.2    Mennear, J.H.3    Bernard, B.K.4
  • 20
    • 27544464079 scopus 로고    scopus 로고
    • Effects of the liquid yogurts containing "lactotripeptide (VPP, IPP)" on high-normal blood pressure
    • In Japanese, English abstract
    • Nakamura, Y., O. Kajimoto, K. Kaneko, K. Aihara, J. Mizitani, N. Ikeda, A. Nishimura, and Y. Kajimoto. 2004. Effects of the liquid yogurts containing "lactotripeptide (VPP, IPP)" on high-normal blood pressure. [In Japanese, English abstract.] J. Nutr. Food 7:123-137.
    • (2004) J. Nutr. Food , vol.7 , pp. 123-137
    • Nakamura, Y.1    Kajimoto, O.2    Kaneko, K.3    Aihara, K.4    Mizitani, J.5    Ikeda, N.6    Nishimura, A.7    Kajimoto, Y.8
  • 21
    • 0030093369 scopus 로고    scopus 로고
    • Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats
    • Nakamura Y., O. Masuda, and T. Takano. 1996. Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 60:488-489.
    • (1996) Biosci. Biotechnol. Biochem. , vol.60 , pp. 488-489
    • Nakamura, Y.1    Masuda, O.2    Takano, T.3
  • 22
    • 0029286291 scopus 로고
    • Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk
    • Nakamura Y., N. Yamamoto, K. Sakai, S. Okubo, S. Yamasaki, and T. Takano. 1995a. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 78:777-783.
    • (1995) J. Dairy Sci. , vol.78 , pp. 777-783
    • Nakamura, Y.1    Yamamoto, N.2    Sakai, K.3    Okubo, S.4    Yamasaki, S.5    Takano, T.6
  • 23
    • 0029319296 scopus 로고
    • Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme
    • Nakamura Y., N. Yamamoto, K. Sakai, and T. Takano. 1995b. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. J Dairy Sci. 78:1253-1257.
    • (1995) J. Dairy Sci. , vol.78 , pp. 1253-1257
    • Nakamura, Y.1    Yamamoto, N.2    Sakai, K.3    Takano, T.4
  • 24
    • 0017578611 scopus 로고
    • Design of specific inhibitors of angiotensin-converting enzyme: New class of orally active antihypertensive agents
    • Ondetti, M. A., B. Rubin, and D. W. Cushman. 1977. Design of specific inhibitors of angiotensin-converting enzyme: New class of orally active antihypertensive agents. Science 196:441-444.
    • (1977) Science , vol.196 , pp. 441-444
    • Ondetti, M.A.1    Rubin, B.2    Cushman, D.W.3
  • 25
    • 0037307257 scopus 로고    scopus 로고
    • A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects
    • Seppo, L., T. Jauhiainen, T. Poussa, and R. Korpela. 2003. A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am. J. Clin. Nutr., 77:326-330.
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 326-330
    • Seppo, L.1    Jauhiainen, T.2    Poussa, T.3    Korpela, R.4
  • 26
    • 0036004437 scopus 로고    scopus 로고
    • The effect of a Lactobacillus helveticus LBK-16 H fermented milk on hypertension-a pilot study on humans
    • Seppo, L., O. Kerojoki, T. Suomalainen, and R. Korpela. 2002. The effect of a Lactobacillus helveticus LBK-16 H fermented milk on hypertension-a pilot study on humans. Milchwissenschaft 57:124-127.
    • (2002) Milchwissenschaft , vol.57 , pp. 124-127
    • Seppo, L.1    Kerojoki, O.2    Suomalainen, T.3    Korpela, R.4
  • 27
    • 8844281530 scopus 로고    scopus 로고
    • Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension
    • Tuomilehto, J., J. Lindstrom, J. Hyyrynen, R. Korpela, M.-L. Karhunen, L. Mikkola, T. Jauhiainen, L. Seppo, and A. Nissinen. 2004. Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension. J. Hum. Hypertens. 18:795-802.
    • (2004) J. Hum. Hypertens. , vol.18 , pp. 795-802
    • Tuomilehto, J.1    Lindstrom, J.2    Hyyrynen, J.3    Korpela, R.4    Karhunen, M.-L.5    Mikkola, L.6    Jauhiainen, T.7    Seppo, L.8    Nissinen, A.9
  • 29
    • 0028414339 scopus 로고
    • Antihypertensive effect of the peptides derived from casein by an extracellular proteinase derived from Lactobacillus helveticus CP790
    • Yamamoto, N., A. Akino, and T. Takano. 1994a. Antihypertensive effect of the peptides derived from casein by an extracellular proteinase derived from Lactobacillus helveticus CP790. J. Dairy Sci. 77:917-922.
    • (1994) J. Dairy Sci. , vol.77 , pp. 917-922
    • Yamamoto, N.1    Akino, A.2    Takano, T.3
  • 30
    • 85008124093 scopus 로고
    • Antihypertensive effects of different kinds of fermented milk in spontaneously hypertensive rats
    • Yamamoto, N., A. Akino, and T. Takano. 1994b. Antihypertensive effects of different kinds of fermented milk in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 58:776-778.
    • (1994) Biosci. Biotechnol. Biochem. , vol.58 , pp. 776-778
    • Yamamoto, N.1    Akino, A.2    Takano, T.3
  • 32
    • 27544465695 scopus 로고    scopus 로고
    • Effect of large intake of tablets containing "lactotripeptides (VPP, IPP)" on blood pressure, pulse rate and clinical parameters in healthy volunteers
    • In Japanese, English abstract
    • Yasuda, K., K. Aihara, K. Komazaki, M. Mochii, and Y. Nakamura. 2001. Effect of large intake of tablets containing "lactotripeptides (VPP, IPP)" on blood pressure, pulse rate and clinical parameters in healthy volunteers. [In Japanese, English abstract.] J. Nutr. Food 4:63-72.
    • (2001) J. Nutr. Food , vol.4 , pp. 63-72
    • Yasuda, K.1    Aihara, K.2    Komazaki, K.3    Mochii, M.4    Nakamura, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.