Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L- proline and L-isoleucyl-L-prolyl-L-proline): IX. Evaluation of the mutagenic potential of synthesized L-valyl-L-prolyl-L-proline in the Salmonella- Escherichia coli/microsome, incorporation assay

International Journal of Toxicology

Volumn 24, Issue SUPPL. 4, 2005, Pages 107-113

  Bernard, Bruce K ^a   Nakamura, Yasunori ^b   Aihara, Kotaro ^b   Mennear, John H ^c  

^a GENERAL DYNAMICS   (United States)

^b CALPIS Co Ltd   (Japan)

^c CAMPBELL UNIVERSITY   (United States)

Author keywords

Ames Test; Casein Hydrolysate; E. coli; IPP; Lactobacillus helveticus Fermented Milk; Mutagenicity Testing; Salmonella typhimurium; Tripeptides; VPP

Indexed keywords

2 AMINOANTHRACENE; 2 NITROFLUORENE; AMINOACRIDINE; AROCLOR 1254; ETHYLNITRONITROSOGUANIDINE; ISOLEUCYLPROLYLPROLINE; SODIUM AZIDE; TRIPEPTIDE; UNCLASSIFIED DRUG; VALYLPROLYLPROLINE;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; ESCHERICHIA COLI; LIVER HOMOGENATE; METABOLIC REGULATION; MICROSOME; MUTAGENICITY; MUTATION; NONHUMAN; RAT; SALMONELLA TYPHIMURIUM;

ANIMALS; ANTHRACENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MALE; MICROSOMES, LIVER; MUTAGENICITY TESTS; MUTAGENS; MUTATION; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM; SODIUM AZIDE; TOXICITY TESTS;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA; ESCHERICHIA COLI; LACTOBACILLUS HELVETICUS; SALMONELLA; SALMONELLA TYPHIMURIUM;

EID: 27544452986     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810500259689     Document Type: Article

References (12)

1. Ames B. N., J. McCann, and E. Yamasaki. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat. Res. 31:347-364.
2. Bernard, B. K., Y. Nakamura, I. Bando, and J. H. Mennear. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): II. Introduction. Int. J. Toxicol. 24(Suppl. 4):5-11.
3. Draper, N. R., and H. Smith, Jr. 1981. Applied regression analysis, 2nd ed. New York: John Wiley & Sons, Inc.
4. Dunnett, C. W. 1955. A multiple comparison procedure for comparing several treatments with a control. J. Am. Star. Assoc. 50:1096-1121.
5. Kurosaki, T., M. Maeno, J. H. Mennear, and B. K. Bernard. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VI. Effects of Lactobacillus helveticus fermented milk powder on fertility and reproductive performance of rats. Int. J. Toxicol. 24(Suppl. 4):61-89.
6. Levene, H. 1960. Robust tests for equality of variance. In Contributions to prob ability and statistics, ed. I. Olkin, 278-292. Stanford, CA: Stanford University Press.
7. Maeno, M., S. Mizuno, J.H. Mennear, and B.K. Bernard. 2005a. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VIII. Assessment of cytotoxicity and clastogenicity of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented milk powders in Chinese hamster lung cells. Int. J. Toxicol. 24(Suppl. 4):97-105.
8. Maeno, M., Y. Nakamura, J. H. Mennear, and B. K. Bernard. 2005b. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): III. Single- and/or repeated-dose toxicity of tripeptides-containing Lactobacillus helveticus-fermented milk powder and casein hydrolysate in rats. Int. J. Toxicol. 24(Suppl. 4):13-23.
9. Maron, D. M., and B. N. Ames. 1983. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113:173-215.
10. Matsuura, K., J. H. Mennear, M. Maeno, and B. K. Bernard. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VII. Micronucleus test of tripeptides- containing casein hydrolysate and Lactobacillus helveticus-fermented milk powders in rats and mice. Int. J. Toxicol. 24(Suppl. 4):91-96.
11. Mizuno, S., J. H. Mennear, K. Matsuura, and B. K. Bernard. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): V. A 13-week toxicity study of tripeptides-containing casein hydrolysate in male and female rats. Int. J. Toxicol. 24(Suppl.4):41-59.
12. Nakamura, Y., I. Bando, J. H. Mennear, and B. K. Bernard. 2005. Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): IV. Assessment of the repeated-dose toxicological potential of synthesized L-valyl-L-prolyl-L-proline in male and female rats and dogs. Int. J. Toxicol. 24(Suppl. 4):25-39.