An electrically active microneedle array for electroporation of skin for gene delivery

Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05

Volumn 2, Issue , 2005, Pages 1513-1516

  Choi, Seong O ^a   Park, Jung Hwan ^a,b   Choi, Yoonsu ^a   Kim, Yeuchun ^b   Gill, Harvinder S ^c   Yoon, Yong Kyu ^a   Prausnitz, Mark R ^b,c   Allen, Mark G ^a,b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b Georgia Institute of Technology   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Electroporation; Gene delivery; Laser ablation; Micromolding; Microneedle

Indexed keywords

GENE DELIVERY; MICROMOLDING TECHNOLOGY; MICRONEEDLES; PATTERNING;

ARRAYS; CELL MEMBRANES; ELECTRODEPOSITION; GENES; GENETIC ENGINEERING; LASER ABLATION; MATHEMATICAL MODELS; MOLDING; NEEDLES; POLYMETHYL METHACRYLATES; SKIN; VACCINES;

MICROELECTROMECHANICAL DEVICES;

EID: 27544469993     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (5)

1. K. K. Peachman, M. Rao, C. R. Alving, "Immunization with DNA through the skin," Methods, 31, 232-42 (2003).
2. M. J. Jaroszeski, R. Heller, and R. Gilbert, Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery, Humana Press, Totowa, NJ, 2000.
3. A. D. King, R. E. Walters, "Delivery of macromolecules into cells," U.S.Patent 6,603,998, 2003.
4. th IEEE Int. Conf. MEMS, pp. 383-6, Maastricht, Netherlands, Jan. 25-29, 2004.
5. K. Kim, D. S. Park, H. M. Lu, W. Che, K. Kim, J. Lee, and C. H. Ahn, "A tapered hollow metallic microneedle array using backside exposure of SU-8," J. Micromech. Microeng., 14, 597-603 (2004).