Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix

Human Pathology

Volumn 36, Issue 11, 2005, Pages 1217-1225

  Yajima, Nobuhisa ^a   Wada, Ryuichi ^a   Yamagishi, Shin Ichiro ^a   Mizukami, Hiroki ^a   Itabashi, Chieko ^a   Yagihashi, Soroku ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Appendix; Epithelial neoplasm; Immunohistochemistry; p53

Indexed keywords

CHROMOGRANIN A; CYTOKERATIN; CYTOKERATIN 20; CYTOKERATIN 7; MUCIN; MUCIN 1; MUCIN 2; MUCIN 5AC; MUCIN 6; PROTEIN P53; UVOMORULIN;

ADENOMA; ADULT; AGED; APPENDIX CANCER; ARTICLE; CARCINOMA; CLINICAL ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; EPITHELIUM; EXON; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; NEUROSECRETORY CELL; PATHOLOGY; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; APPENDICEAL NEOPLASMS; BASE SEQUENCE; CADHERINS; CHROMOGRANIN A; CHROMOGRANINS; DNA MUTATIONAL ANALYSIS; FEMALE; HISTORY, 16TH CENTURY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; KERATINS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUCINS; NEOPLASMS, GLANDULAR AND EPITHELIAL; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 27544461589     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2005.08.022     Document Type: Article

References (27)

1. N.J. Carr, W.F. McCarthy, and L.H. Sobin Epithelial noncarcinoid tumors and tumor-like lesions of the appendix. A clinicopathologic study of 184 patients with a multivariate analysis of prognostic factors Cancer 75 1995 757 768
2. N.J. Carr, M.J. Arends, and G.T. Deans Tumours of the appendix R. Stanley H. Aaltonen L.A. Aaltonen Pathology and genetics of tumours of the digestive system: World Health Organization classification of tumours 2000 IARC press Lyon 94 98
3. N.S. Lo, and M.G. Sarr Mucinous cystadenocarcinoma of the appendix. The controversy persists: a review Hepatogastroenterology 50 2003 432 437
4. M.E. McCusker, T.R. Cote, L.X. Clegg, and L.H. Sobin Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998 Cancer 94 2002 3307 3312
5. J. Misdraji, R.K. Yantiss, F.M. Graeme-Cook, U.J. Balis, and R.H. Young Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases Am J Surg Pathol 27 2003 1089 1103
6. N.J. Carr, and L.H. Sobin Unusual tumors of the appendix and pseudomyxoma peritonei Semin Diagn Pathol 13 1996 314 325
7. E. Higa, J. Rosai, C.A. Pizzimbono, and L. Wise Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix. A re-evaluation of appendiceal "mucocele" Cancer 32 1973 1525 1541
8. B.M. Ronnett, H. Yan, R.J. Kurman, B.M. Shmookler, L. Wu, and P.H. Sugarbaker Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosis Cancer 92 2001 85 91
9. H. Ji, C. Isacson, J.D. Seidman, R.J. Kurman, and B.M. Ronnett Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas Int J Gynecol Pathol 21 2002 391 400
10. J. Misdraji, L.J. Burgart, and G.Y. Lauwers Defective mismatch repair in the pathogenesis of low-grade appendiceal mucinous neoplasms and adenocarcinomas Mod Pathol 17 2004 1447 1454
11. W. Kabbani, P.S. Houlihan, R. Luthra, S.R. Hamilton, and A. Rashid Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations Mod Pathol 15 2002 599 605
12. D. Maru, T.T. Wu, A. Canada, P.S. Houlihan, S.R. Hamilton, and A. Rashid Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas Oncogene 23 2004 859 864
13. M.H. Lyda, A. Noffsinger, J. Belli, J. Fischer, and C.M. Fenoglio-Preiser Multifocal neoplasia involving the colon and appendix in ulcerative colitis: pathological and molecular features Gastroenterology 115 1998 1566 1573
14. A. Scarpa, P. Capelli, and K. Mukai Pancreatic adenocarcinomas frequently show p53 mutations Am J Pathol 142 1993 1534 1543
15. M.J. Lee, H.S. Lee, W.H. Kim, Y. Choi, and M. Yang Expression of mucins and cytokeratins in primary carcinomas of the digestive system Mod Pathol 16 2003 403 410
16. A. Biemer-Huttmann, M.D. Walsh, and M.A. McGuckin Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum J Histochem Cytochem 47 1999 1039 1047
17. S.B. Ho, L.L. Shekels, and N.W. Toribara Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium Cancer Res 55 1995 2681 2690
18. S.B. Ho, G.A. Niehans, and C. Lyftogt Heterogeneity of mucin gene expression in normal and neoplastic tissues Cancer Res 53 1993 641 651
19. P.G. Chu, and L.M. Weiss Keratin expression in human tissues and neoplasms Histopathology 40 2002 403 439
20. Z.M. Chen, and H.L. Wang Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine Am J Surg Pathol 28 2004 1352 1359
21. J.C. Byrd, and R.S. Bresalier Mucins and mucin binding proteins in colorectal cancer Cancer Metastasis Rev 23 2004 77 99
22. G. Zamboni, A. Scarpa, and G. Bogina Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors Am J Surg Pathol 23 1999 410 422
23. D.G. Bostwick, H.D. Tazelaar, S.C. Ballon, M.R. Hendrickson, and R.L. Kempson Ovarian epithelial tumors of borderline malignancy. A clinical and pathologic study of 109 cases Cancer 58 1986 2052 2065
24. J.L. Rutgers, and R.E. Scully Ovarian mullerian mucinous papillary cystadenomas of borderline malignancy. A clinicopathologic analysis Cancer 61 1988 340 348
25. M.K.G. Tse, K.F.T. Ma, C.W.W. Chu, W.M.W. Lam, S.P.C. Poon, and W.-C. Chan Neuroendocrine differentiation in pure type mammary mucinous carcinoma is associated with favorable histologic and immunohistochemical parameters Mod Pathol 17 2004 568 572
26. N.J. Carr, T.S. Emory, and L.H. Sobin Epithelial neoplasms of the appendix and colorectum: an analysis of cell proliferation, apoptosis, and expression of p53, CD44, bcl-2 Arch Pathol Lab Med 126 2002 837 841
27. G.R. Williams, C.E. du Boulay, and W.R. Roche Benign epithelial neoplasms of the appendix: classification and clinical associations Histopathology 21 1992 447 451