Antagonism, non-native interactions and non-two-state folding in S6 revealed by double-mutant cycle analysis

Protein Engineering, Design and Selection

Volumn 18, Issue 11, 2005, Pages 547-557

  Otzen, Daniel ^a  

^a AALBORG UNIVERSITY   (Denmark)

Author keywords

Chevron plots; Crystallography; Interaction energies; Kinetics; Mutants

Indexed keywords

CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; GENETIC ENGINEERING; PROTEINS; REACTION KINETICS;

CHEVRON PLOTS; INTERACTION ENERGIES; MUTANTS; PROTEIN TOPOLOGY;

MUTAGENESIS;

LEUCINE; MUTANT PROTEIN; PROTEIN S6; SODIUM CHLORIDE;

ANALYTIC METHOD; ARTICLE; CRYSTAL STRUCTURE; DENATURATION; ENERGY; KINETICS; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTANT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE;

KINETICS; LEUCINE; MUTATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RIBOSOMAL PROTEIN S6; THERMODYNAMICS;

EID: 27544451147     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzi063     Document Type: Article

References (39)

1. Carter,P.J., Winter,G., Wilkinson,A.J. and Fersht,A.R. (1984) Cell, 38, 835-840.
2. Chiti,F., Taddei,N., White,P.M., Bucciantini,M., Magherini,F., Stefani,M. and Dobson,C.M. (1999) Nat. Struct. Biol., 6, 1005-1009.
3. Dill,K. (1999) Protein Sci., 8, 1166-1180.
4. Eriksson,A.E., Baase,W.A., Zhang,X.J., Heinz,D.W., Blaber,M., Baldwin,E.P. and Matthews,B.W. (1992) Science, 255, 178-183.
5. Fersht,A.R., Shi,J.P., Knill-Jones,J., Lowe,D.M., Wilkinson,A.J., Blow,D.M., Brick,P., Carter,P., Waye,M.M.Y. and Winter,G. (1985) Nature, 314, 235-238.
6. Flanagan,J.M., Kataoka,M., Fujisawa,T. and Engelman,D.M. (1993) Biochemistry, 32, 10359-10370.
7. Hidalgo,P. and MacKinnon,R. (1995) Science, 268, 307-310.
8. Horovitz,A (1996) Fold. Des., 1, R121-R126.
9. Horovitz,A and Fersht,A.R. (1990) J. Mol. Biol., 214, 613-617.
10. Horovitz,A. and Fersht,A.R. (1992) J. Mol. Biol., 224, 733-740.
11. Horovitz,A., Serrano,L., Avron,B., Bycroft,M. and Fersht,A.R. (1990) J. Mol. Biol., 216, 1031-1044.
12. Horovitz,A., Serrano,L. and Fersht,A.R. (1991) J. Mol. Biol., 219, 5-9.
13. Itzhaki,L.S., Otzen,D.E. and Fersht,A.R. (1995) J. Mol. Biol., 254, 260-288.
14. Jackson,S.E. and Fersht,A.R. (1993) Biochemistry, 32, 13909-13916.
15. Karpusas,M., Baase,W.A., Matsumura,M. and Matthews,B.W. (1989) Proc. Natl Acad. Sci. USA, 86, 8237-8241.
16. Lindahl,M. et al. (1994) EMBO J., 13, 1249-1254.
17. Loewenthal,R., Sancho,J. and Fersht,A.R. (1992) J. Mol. Biol., 224, 759-770.
18. Maxwell,K.L. et al. (2005) Protein Sci., 14, 602-616.
19. Mildvan,A.S. (2004) Biochemistry, in press.
20. Onuchic,J.N. and Wolynes,P.G. (2004) Curr. Opin. Struct. Biol., 14, 70-75.
21. Onuchic,J.N., Socci,N.D., Luthey-Schulten,Z. and Wolynes,P.G. (1996) Fold. Des., 1, 441-450.
22. Otzen,D.E. (2005) Biochim. Biophys. Acta, 1750, 146-153.
23. Otzen,D.E. and Fersht,A.R. (1999) Protein Eng., 12, 41-45.
24. Otzen,D.E. and Oliveberg,M. (1999) Proc. Natl Acad. Sci. USA, 96, 11746-11751.
25. Otzen,D.E. and Oliveberg,M. (2002) J. Mol. Biol., 317, 613-627.
26. Otzen,D.E. and Oliveberg,M. (2004) Protein Sci., 13, 3253-3263.
27. Otzen,D.E., Rheinnecker,M. and Fersht,A.R. (1995) Biochemistry, 34, 13051-13058.
28. Otzen,D.E., Kristensen,O., Proctor,M. and Oliveberg,O. (1999) Biochemistry, 38, 6499-6511.
29. Parker,M.J., Spencer,J. and Clarke,A.R. (1995) J. Mol. Biol., 253, 771-786.
30. Parker,M.J., Sessions,R.B., Badcoe,I.G. and Clarke,A.R. (1996) Fold. Des., 1, 145-156.
31. Plaxco,K.W., Simons,K.T. and Baker,D. (1998) J. Mol. Biol., 277, 985-994.
32. Privalov,P.L. and Gill,S.J. (1988) Adv. Protein Chem., 39, 191-234.
33. Quiram,P.A., Jones,J.J. and Sine,S.M. (1999) J. Biol. Chem., 274, 19517-19524.
34. Schreiber,G. and Fersht,A.R. (1995) J. Mol. Biol., 248, 478-486.
35. Serrano,L., Bycroft,M. and Fersht,A.R. (1991) J. Mol. Biol., 218, 465-475.
36. Tanford,C. (1970) Adv. Protein Chem., 24, 1-95.
37. Varadarajan,R., Connelly,P.R., Sturtevant,J.M. and Richards,F.M. (1992) Biochemistry, 31, 1421-1426.
38. Wells,J.A. (1990) Biochemistry, 29, 8509-8517.
39. Wright,C.F., Lindorff-Larsen,K., Randles,L.G. and Clarke,J. (2003) Nat. Struct. Biol., 10, 658-62.