Prophylactic intravenous ondansetron and dolasetron in intrathecal morphine-induced pruritus: A randomized, double-blinded, placebo-controlled study

Anesthesia and Analgesia

Volumn 101, Issue 5, 2005, Pages 1516-1520

  Iatrou, Christos A ^b   Dragoumanis, Christos K ^a   Vogiatzaki, Theodosia D ^b   Vretzakis, George I ^b   Simopoulos, Constantinos E ^b   Dimitriou, Vasilios K ^b  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DOLASETRON MESILATE; MORPHINE; ONDANSETRON; PLACEBO; SEROTONIN 3 ANTAGONIST;

ADULT; AGED; ANESTHESIOLOGICAL TECHNIQUES; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE ANALGESIA; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROPHYLAXIS; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SPINAL ANESTHESIA;

EID: 27444441273     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000181338.35454.6A     Document Type: Article

References (19)

1. Gwirtz KH, Young JV, Byers RS, et al. The safety and efficacy of intrathecal opioid analgesia for acute postoperative pain: seven years' experience with 5969 surgical patients at Indiana University Hospital. Anesth Analg 1999;88:599-604.
2. Charuluxananan S, Kyokong O, Somboonviboon W, et al. Nalbuphine versus propofol for treatment of intrathecal morphine-induced pruritus after cesarean delivery. Anesth Analg 2001;93:162-5.
3. Yeh HM, Chen LK, Lin CJ, et al. Prophylactic intravenous ondansetron reduces the incidence of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery. Anesth Analg 2000;91:172-5.
4. Charuluxananan S, Kyokong O, Somboonviboon W, et al. Nalbuphine versus ondansetron for prevention of intrathecal morphine-induced pruritus after cesarean delivery. Anesth Analg 2003;96:1789-93.
5. Beilin Y, Bernstein HH, Zucker-Pinchoff B, et al. Subhypnotic doses of propofol do not relieve pruritus induced by intrathecal morphine after cesarean section. Anesth Analg 1998;86:310-3.
6. Szarvas S, Harmon D, Murphy D. Neuraxial. opioid-induced pruritus: a review. J Clin Anesth 2003;15:234-9.
7. Dimitriou V, Voyagis GS. Opioid-induced pruritus: repeated versus single dose ondansetron administration in preventing pruritus after intrathecal morphine. Br J Anaesth 1999;83:822-3.
8. Szarvas S, Chellapuri RS, Harmon DC, et al. A comparison of dexamethasone, ondansetron, and dexamethasone plus ondansetron as prophylactic antiemetic and antipruritic therapy in patients receiving intrathecal morphine for major orthopedic surgery. Anesth Analg 2003;97:259-63.
9. Korttila K, Clergue F, Leeser J, et al. Intravenous dolasetron and ondansetron in prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. Acta Anaesthesiol Scand 1997;41:914-22.
10. Piper SN, Suttner SW, Rohm KD, et al. Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Can J Anaesth 2002;49:1021-8.
11. Somrat C, Oranuch K, Ketchada U, et al. Optimal dose of nalbuphine for treatment of intrathecal-morphine-induced pruritus after caesarean section. J Obstet Gynaecol Res 1999;25:209-13.
12. Ikoma A, Rukwied R, Stander S, et al. Neurophysiology of pruritus: interaction of itch and pain. Arch Dermatol 2003;139:1475-8.
13. Zeitz KP, Guy N, Malmberg AB, et al. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci 2002;22:1010-9.
14. Arcioni R, della Rocca M, Romano S, et al. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans. Anesth Analg 2002;94:1553-7.
15. Fan P. Nonopioid mechanism of morphine modulation of the activation of 5-hydroxytryptamine type 3 receptors. Mol Pharmacol 1995;47:491-5.
16. Yazigi A, Chalhoub V, Madi-Jebara S, et al. Prophylactic ondansetron is effective in the treatment of nausea and vomiting but not on pruritus after cesarean delivery with intrathecal sufentanil-morphine. J Clin Anesth 2002;14:183-6.
17. Colbert S, O'Hanlon DM, Calvin S, et al. The effect of rectal diclofenac on pruritus in patients receiving intrathecal morphine. Anaesthesia 1999;54:948-52.
18. Cepeda MS, Alvarez H, Morales O, Carr DB. Addition of ultralow dose naloxone to postoperative morphine PCA: unchanged analgesia and opioid requirement but decreased incidence of opioid side effects. Pain 2004;107:41-6.
19. Apfel CC, Roewer N, Korttila K. How to study postoperative nausea and vomiting. Acta Anaesthesiol Scand 2002;46:921-928.