Cross-species replication of a serum osteocalcin quantitative trait locus on human chromosome 16q in pedigreed baboons

Calcified Tissue International

Volumn 77, Issue 4, 2005, Pages 205-211

  Havill, L M ^a   Cox, L A ^a   Rogers, J ^a,b   Mahaney, M C ^a,b  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

Bone formation; Bone Gla protein; Nonhuman primate model; Osteoporosis risk factors; Skeletal genetics

Indexed keywords

OSTEOCALCIN;

ANIMAL EXPERIMENT; ARTICLE; BABOON; BONE METABOLISM; CHROMOSOME 16Q; CONTROLLED STUDY; FEMALE; GENE REPLICATION; GENETIC LINKAGE; GENOME ANALYSIS; HERITABILITY; HUMAN; MALE; NONHUMAN; OSSIFICATION; PEDIGREE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT LOCUS;

ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 16; FEMALE; GENOME; HUMANS; MALE; MODELS, ANIMAL; OSTEOCALCIN; PAPIO; PEDIGREE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; SPECIES SPECIFICITY; VARIATION (GENETICS);

EID: 27444437830     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-005-0056-1     Document Type: Article

References (38)

1. Khosla S, Kleerekoper M (2003) Biochemical markers of bone turnover. In: Favus MJ (ed.) Primer on the metabolic bone diseases and disorders of mineral metabolism. American Society for Bone and Mineral Research, Washington, DC, pp 166-172
2. Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan J (2000) The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int 11(suppl 6):S2-S17
3. Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ (1984) Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet 1:1091-1093
4. Ross PD (1999) Predicting bone loss and fracture risk with biochemical markers: a review. J Clin Densitom 2:285-294
5. Szulc P, Seeman E, Delmas PD (2000) Biochemical measurements of bone turnover in children and adolescents. Osteoporos Int 11:281-294
6. Eastell R, Simmons PS, Colwell A, Assiri AM, Burritt MF, Russell RG, Riggs BL (1992) Nyctohemeral changes in bone turnover assessed by serum bone Gla-protein concentration and urinary deoxypyridinoline excretion: effects of growth and ageing. Clin Sci (Lond) 83:375-382
7. Khosla S, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL (1998) Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266-2274
8. Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (1989) Chromosomal localization of the human osteocalcin gene. Endocrinology 124:2648-2650
9. Raymond MH, Schutte BC, Torner JC, Burns TL, Willing MC (1999) Osteocalcin: genetic and physical mapping of the human gene BGLAP and its potential role in postmenopausal osteoporosis. Genomics 60:210-217
10. Morrison NA, Yeoman R, Kelly PJ, Eisman JA (1992) Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci USA 89:6665-6669
11. Garnero P, Arden NK, Griffiths G, Delmas PD, Spector TD (1996) Genetic influence on bone turnover in postmenopausal twins. J Clin Endocrinol Metab 81:140-146
12. Kelly PJ, Hopper JL, Macaskill GT, Pocock NA, Sambrook PN, Eisman JA (1991) Genetic factors in bone turnover. J Clin Endocrinol Metab 72:808-813
13. Livshits G, Yakovenko C, Kobyliansky E (2000) Quantitative genetic analysis of circulating levels of biochemical markers of bone formation. Am J Med Genet 94:324-331
14. Mitchell BD, Cole SA, Bauer RL, Iturria SJ, Rodriguez EA, Blangero J, MacCluer JW, Hixson JE (2000) Genes influencing variation in serum osteocalcin concentrations are linked to markers on chromosomes 16q and 20q. J Clin Endocrinol Metab 85:1362-1366
15. Cerroni AM, Tomlinson GA, Turnquist JE, Grynpas MD (2000) Bone mineral density, osteopenia, and osteoporosis in the rhesus macaques of Cayo Santiago. Am J Phys Anthropol 113:389-410
16. Aufdemorte TB, Fox WC, Miller D, Buffum K, Holt GR, Carey KD (1993) A nonhuman primate model for the study of osteoporosis and oral bone loss. Bone 14:581-586
17. Kammerer CM, Sparks ML, Rogers J (1995) Effects of age, sex, and heredity on measures of bone mass in baboons (Papio hamadryas). J Med Primatol 24:236-242
18. DeRousseau CJ (1985) Aging in the musculoskeletal system of rhesus monkeys: III. Bone loss. Am J Phys Anthropol 68:157-167
19. Chen LD, Kushwaha RS, McGill HC Jr, Rice KS, Carey KD (1998) Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). Atherosclerosis 136:89-98
20. Brommage R (2001) Perspectives on using nonhuman primates to understand the etiology and treatment of postmenopausal osteoporosis. J Musculoskel Neuron Interact 1:307-325
21. Hendrickx A, Dukelow W (1995) Reproductive biology. In: Henrickson R (ed.) Nonhuman primates in biomedical research: biology and management. Academic Press, San Diego, pp 147-191
22. Havill LM, Mahaney MC, Czerwinski SA, Carey KD, Rice K, Rogers J (2003) Bone mineral density reference standards in adult baboons (Papio hamadryas) by sex and age. Bone 33:877-888
23. National Research Council (1996) Guide for the care and use of laboratory animals. National Academy of Sciences, Washington, DC
24. Quidel Corporation (2004) Metra™ osteocalcin, http:// www.quidel.com/Products/BoneHealth/Research/metra_ osteocalcin_desc.php?section= pro
25. Rogers J, Mahaney MC, Witte SM, Nair S, Newman D, Wedel S, Rodriguez LA, Rice KS, Slifer SH, Perelygin A, Slifer M, Palladino-Negro P, Newman T, Chambers K, Joslyn G, Parry P, Morin PA (2000) A genetic linkage map of the baboon (Papio hamadryas) genome based on human microsatellite polymorphisms. Genomics 67:237-247
26. Matise TC, Perlin M, Chakravarti A (1994) Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Nat Genet 6:384-390
27. Matise TC, Schroeder MD, Chiarulli DM, Weeks DE (1995) Parallel computation of genetic likelihoods using CRI-MAP, PVM, and a network of distributed workstations. Hum Hered 45:103-116
28. Havill LM, Mahaney MC, Cox LA, Morin PA, Joslyn G, Rogers J (2005) A QTL for normal variation in forearm BMD in pedigreed baboons maps to the ortholog of human chromosome 11q. J Clin Endocrinol Metab 90:3638-3645
29. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
30. Fulker DW, Cherny SS, Cardon LR (1995) Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet 56:1224-1233
31. Ott J (1988) Analysis of human genetic linkage. Johns Hopkins University Press, Baltimore
32. Feingold E, Brown PO, Siegmund D (1993) Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent. Am J Hum Genet 53:234-251
33. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
34. Martin LJ, Carey KD, Comuzzie AG (2003) Variation in menstrual cycle length and cessation of menstruation in captive baboons. Mech Ageing Dev 124:865-871
35. Johansen JS, Giwercman A, Hartwell D, Nielsen CT, Price PA, Christiansen C, Skakkebaek NE (1988) Serum bone Gla-protein as a marker of bone growth in children and adolescents: correlation with age, height, serum insulin-like growth factor I, and serum testosterone. J Clin Endocrinol Metab 67:273-278
36. Okazaki M, Takeshita S, Kawai S, Kikuno R, Tsujimura A, Kudo A, Amann E (1994) Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem 269:12092-12098
37. Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (1998) Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Genomics 49:467-471
38. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 63:861-869