Glucocorticoid receptor α expression in the intrahepatic biliary epithelium and adjuvant steroid therapy in infants with biliary atresia

Journal of Pediatric Surgery

Volumn 40, Issue 10, 2005, Pages 1574-1580

  Tatekawa, Yukihiro ^a   Muraji, Toshihiro ^a   Tsugawa, Chikara ^a  

^a KOBE CHILDREN S HOSPITAL   (Japan)

Author keywords

Adjuvant steroid therapy; Biliary atresia; Glucocorticoid receptor ; Liver injury

Indexed keywords

BILIRUBIN; CYTOPLASMIC RECEPTOR; EOSIN; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; HEMATOXYLIN; PREDNISOLONE; STEROID; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ARTICLE; BILE DUCT ATRESIA; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG DOSE REGIMEN; EPITHELIUM; ESOPHAGUS VARICES; HISTOLOGY; HOSPITAL ADMISSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; INFANT DISEASE; INTRAHEPATIC BILE DUCT; LIVER BIOPSY; LIVER INJURY; LIVER SURGERY; LIVER TRANSPLANTATION; PORTOENTEROSTOMY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RANK SUM TEST; RECEPTOR UPREGULATION; SCORING SYSTEM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STEROID THERAPY;

BILE DUCTS, INTRAHEPATIC; BILIARY ATRESIA; EPITHELIUM; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; INFANT; LIVER; PREDNISOLONE; RECEPTORS, GLUCOCORTICOID; SEVERITY OF ILLNESS INDEX;

EID: 27444435882     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2005.06.017     Document Type: Article

References (12)

1. H. Kobayashi, A. Yamataka, and G.J. Lane Levels of circulating antiinflammatory cytokine interleukin-1 receptor antagonist and proinflammatory cytokines at different stages of biliary atresia J Pediatr Surg 37 2002 1038 1041
2. P.W. Dillon, E. Owings, and R. Cilley Immunosuppression as adjuvant therapy for biliary atresia J Pediatr Surg 36 2001 80 85
3. R.L. Meyers, L.S. Book, and M.A. O'Gorman High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia J Pediatr Surg 38 2003 406 411
4. R.H. Oakley, J.C. Webster, and M. Sar Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor Endocrinology 138 1997 5028 5038
5. L. Pujols, J. Mullol, and J. Roca-Ferrer Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues Am J Physiol Cell Physiol 283 2002 C1324 C1331
6. J.C. Webster, R.H. Oakley, and C.M. Jewell Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance Proc Natl Acad Sci U S A 98 2001 6865 6870
7. F.M. Karrer, and J.R. Lilly Corticosteroid therapy in biliary atresia J Pediatr Surg 20 1985 693 695
8. T. Muraji, and Y. Higashimoto The improved outlook for biliary atresia with corticosteroid therapy J Pediatr Surg 32 1997 1103 1107
9. T. Muraji, E. Nishijima, and Y. Higashimoto Biliary atresia: current management and outcome Tohoku J Exp Med 181 1997 155 160 [abstract in English]
10. D. Alvaro, A. Gigliozzi, and L. Marucci Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium Gastroenterology 122 2002 1058 1069
11. Y. Mano, M. Ishii, and H. Okamoto Effect of tumor necrosis factor alpha on intrahepatic bile duct epithelial cell of rat liver Hepatology 23 1996 1602 1607
12. C. Spirli, M.H. Nathanson, and R. Fiorotto Proinflammatory cytokines inhibit secretion in rat bile duct epithelium Gastroenterology 121 2001 156 169