Mutating His29, His125, His133 or His 158 abolishes glycosylphosphatidylinositol-specific phospholipase D catalytic activity

Biochemical Journal

Volumn 391, Issue 2, 2005, Pages 285-289

  Raikwar, Nandita S ^b   Bowen, Rosario F ^b   Deeg, Mark A ^a  

^a INDIANA UNIVERSITY   (United States)

^b NONE

Author keywords

propeller domain; Catalytic activity; Glycosylphosphatidylinositol; Histidine; Mutagenesis; Phospholipase D

Indexed keywords

ALCOHOLS; AMINO ACIDS; CATALYSIS; ENZYMES;

Β-PROPELLER DOMAIN; CATALYTIC ACTIVITY; GLYCOSYLPHOSPHATIDYLINOSITOL; PHOSPHOLIPASE D;

MUTAGENESIS;

GLYCOSYLPHOSPHATIDYLINOSITOL; HISTAMINE; PHOSPHOLIPASE D; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTIDINE; TRYPSIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPUTER MODEL; DNA CLEAVAGE; ENZYME ACTIVITY; GENE MUTATION; HYDROLYSIS; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOUSE; MUTATION; PROTEIN TERTIARY STRUCTURE;

ALCOHOLS; CATALYSTS; HISTIDINE; MUTAGENS;

MURINAE;

AMINO ACID SUBSTITUTION; ANIMALS; CATALYSIS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GLYCOSYLPHOSPHATIDYLINOSITOLS; HISTIDINE; HUMANS; MICE; MUTATION; PHOSPHOLIPASE D; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TRYPSIN;

EID: 27444433845     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050656     Document Type: Article

References (33)

1. Low, M. G. and Brodbeck, U. (1999) Enzymes cleaving the phosphodiester bond in the GPI anchor. In GPI-anchored Membrane Proteins and Carbohydrates (Hoessli, D. C. and Ilangumaran, S., eds.), pp. 167-186, R.G. Landes, Austin
2. Xie, M. and Low, M. G. (1994) Expression and secretion of glycosylphosphatidylinositol-specific phospholipase D by myeloid cell lines. Biochem. J. 297, 547-554
3. Low, M. G. (2000) Structure and function of GPI-specific phospholipases. In PNH and the GPI-linked Proteins (Young, N. G. and Moss, J., eds.), pp. 239-268, Academic Press, San Diego, CA
4. Stadelmann, B., Zurbiggen, A. and Brodbeck, U. (1993) Distribution of glycosylphosphatidylinositol-specific phospholipase D mRNA in bovine tissue sections. Cell Tissue Res. 274, 547-552
5. LeBoeuf, R. C., Caldwell, M., Guo, Y., Metz, C., Davitz, M. A., Olson, L. K. and Deeg, M. A. (1998) Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterization. Mam. Gen. 9, 710-714
6. Brunner, G., Metz, C. N., Nguyen, H., Gabrilove, J., Patel, S. R., Davitz, M. A., Rifkin, D. B. and Wilson, E. L. (1994) An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures. Blood 83, 2115-2125
7. Khan, W. N. and Hammarstrom, S. (1991) Biosynthesis of carcinoembryonic antigen (CEA) gene family members expressed in human tumor cell lines: evidence for cleavage of the glycosyl phosphatidyl inositol (GPI) anchor by GPI-PLC and GPI-PLD. Biochem. Int. 25, 723-731
8. Heller, M., Bütikofer, P. and Brodbeck, U. (1994) Generation by limited proteolysis of a catalytically active 39-kDa protein from the 115-kDa form of phosphatidylinositolglycan-specific phospholipase D from bovine serum. Eur. J. Biochem. 224, 823-833
9. Springer, T. A. (1997) Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. Proc. Natl. Acad. Sci. U.S.A. 94, 65-72
10. Li, D. and Roberts, R. (2001) WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. Cell. Mol. Life Sci. 58, 2085-2097
11. Pons, T., Gomez, R., Chinea, G. and Valencia, A. (2003) Beta-propellers: associated functions and their role in human diseases. Curr. Med. Chem. 10, 505-524
12. Deeg, M. A. and Bowen, R. F. (1999) Midportion antibodies stimulate glycosylphosphatidylinositol-specific phospholipase D activity. Arch. Biochem. Biophys. 370, 278-284
13. Stadelmann, B., Butikofer, P., Konig, A. and Brodbeck, U. (1997) The C-terminus of glycosylphosphatidylinositol-specific phospholipase D is essential for biological activity. Biochim. Biophys. Acta 1355, 107-113
14. 2+ binding studies. J. Biol. Chem. 269, 28963-28971
15. Newton, A. L., Sharpe, B. K., Kwan, A., Mackay, J. P. and Crossley, M. (2000) The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules. J. Biol. Chem. 275, 15128-15134
16. Schwabe, J. W. and Klug, A. (1994) Zinc mining for protein domains. Nat. Struct. Biol. 1, 345-349
17. Gottlin, E. B., Rudolph, A. E., Zhao, Y., Matthews, H. R. and Dixon, J. E. (1998) Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate. Proc. Natl. Acad. Sci. U.S.A. 95, 9202-9207
18. Rigden, D. J. (2004) A distant evolutionary relationship between GPI-specific phospholipase D and bacterial phosphatidylcholine-preferring phospholipase C. FEBS Lett. 569, 229-234
19. Rhode, H., Schulze, M., Cumme, G. A., Gohlert, A., Blume, E., Bublitz, R., Schilling, K. and Horn, A. (2000) Glycosylphosphatidylinositol-specific phospholipase D of human serum activity modulation by naturally occurring amphiphiles. Biol. Chem. 381, 471-485
20. Sung, T. C., Roper, R. L., Zhang, Y., Rudge, S. A., Temel, R., Hammond, S. M., Morris, A. J., Moss, B., Engebrecht, J. and Frohman, M. A. (1997) Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J. 16, 4519-4530
21. Gregory, P., Ziemiecki, A., Zurcher, G., Brodbeck, U. and Butikofer, P. (2003) Anti-mouse GPI-PLD antisera highlight structural differences between murine and bovine GPI-PLDs. Biol. Chem. 384, 1575-1582
22. Flores-Borja, F., Kieszkievicz, J., Church, V., Francis-West, P. H., Schofield, J., Rademacher, T. W. and Lund, T. (2004) Genetic regulation of mouse glycosylphosphatidylinositol-phospholipase D. Biochimie 86, 275-282
23. Deeg, M. A. and Bowen, R. F. (2002) Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol- specific phospholipase D. Biochem. Cell. Biol. 80, 253-260
24. Miles, E. W. (1977) Modification of histidyl residues in proteins by diethylpyrocarbonate. Methods Enzymol. 47, 431-442
25. Quo, L., Groenendyk, J., Papp, S., Dabrowska, M., Knoblach, B., Kay, C., Parker, J. M., Opas, M. and Michalak, M. (2003) Identification of an N-domain histidine essential for chaperone function in calreticulin. J. Biol. Chem. 278, 50645-50653
26. Saito, Y., Ihara, Y., Leach, M. R., Cohen-Doyle, M. F. and Williams, D. B. (1999) Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins. EMBO J. 18, 6718-6729
27. Rodriguez-Crespo, I., Nishida, C. R., Knudsen, G. M. and de Montellano, P. R. (1999) Mutation of the five conserved histidines in the endothelial nitric-oxide synthase hemoprotein domain. No evidence for a non-heme metal requirement for catalysis. J. Biol. Chem. 274, 21617-21624
28. Marti, D. N. and Bosshard, H. R. (2003) Electrostatic interactions in leucine zippers: thermodynamic analysis of the contributions of Glu and His residues and the effect of mutating salt bridges. J. Mol. Biol. 330, 621-637
29. Civenni, G., Butikofer, P., Stadelmann, B. and Brodbeck, U. (1999) In vitro phosphorylation of purified glycosylphosphatidylinositol-specific phospholipase D. Biol. Chem. 380, 585-588
30. Ponting, C. P. and Kerr, I. D. (1996) A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues. Protein Sci. 5, 914-922
31. Koonin, E. V. (1996) A duplicated catalytic motif in a new superfamily of phosphohydrolases and phospholipid synthases that includes poxvirus envelope proteins. Trends Biochem. Sci. 21, 242-243
32. Medh, J. D., Bowen, S. L., Fry, G. L., Ruben, S., Andracki, M., Inoue, I., Lalouel, J. M., Strickland, D. K. and Chapped, D. A. (1996) Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro. J. Biol. Chem. 271, 17073-17080
33. Merkel, M., Kako, Y., Radner, H., Cho, I. S., Ramasamy, R., Brunzell, J. D., Goldberg, I. J. and Breslow, J. L. (1998) Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc. Natl. Acad. Sci. U.S.A. 95, 13841-13846