Split-plot microarray experiments: Issues of design, power and sample size

Applied Bioinformatics

Volumn 4, Issue 3, 2005, Pages 187-194

  Tsai, Pi Wen ^a   Lee, Mei Ling Ting ^b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYSIS OF VARIANCE; ARTICLE; COMPARATIVE STUDY; EXPERIMENTATION; GENE EXPRESSION; GENE IDENTIFICATION; GENETICS; GENOTYPE; HUMAN; STATISTICS;

EID: 27344457150     PISSN: 11755636     EISSN: 11755636     Source Type: Journal    
DOI: 10.2165/00822942-200504030-00003     Document Type: Article

References (15)

1. Kerr MK, Churchill GA. Experimental design for gene expression microarrays. Biostatistics 2001; 2: 183-201
2. Box GEP, Jones S. Split-plot designs for robust product experimentation. J Appl Stat 1992; 19: 3-26
3. Wolfinger RD, Gibson G, Wolfinger ED, et al. Assessing gene significance from cDNA microarray expression data via mixed model. J Comput Biol 2001; 8: 625-37
4. Lee MLT, Lu W, Whitmore GA, et al. Models for microarray gene expression data. J Biopharm Stat 2002; 12: 1-19
5. Hinkelmann K, Kempthorne O. Design and analysis of experiments. Vol. 1. Introduction to experimental design. New York: J Wiley, 1994: 428-47
6. Emptage MR, Hudson-Curtis B, Sen K. Treatment of microarray experiments as split-plot designs. J Biopharm Stat 2003; 13: 157-78
7. Jin W, Riley RM, Wolfinger RD, et al. The contribution of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Nat Genet 2001; 29: 389-95
8. Lee MLT. Analysis of microarray gene expression data. Boston (MA): Kluwer Academic Publishers, 2004: 121-42
9. Dudoit S, Yang YH, Speed TP, et al. Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments. Stat Sin 2002; 12: 111-39
10. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001; 98: 5116-24
11. Efron B, Tibshirani R, Storey JD, et al. Empirical Bayes analysis of a microarray experiment. J Am Stat Assoc 2001; 96: 1151-60
12. Lee MLT, Whitmore GA. Power and sample size for DNA microarray studies. Stat Med 2002; 21: 3543-70
13. Geller SC, Gregg JP, Hagerman P, et al. Transformation and normalization of oligonucleotide microarray data. Bioinformatics 2003; 19: 1817-23
14. Leips J, Mackay TFC. Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density. Genetics 2000; 155: 1773-88
15. Churchill GA, Oliver B. Sex, flies and microarrays. Nat Genet 2001; 29: 355-6