Two distinct types of aspartic proteases in the filarial parasite Brugia malayi: Molecular cloning and tissue distribution

Biomedical Research

Volumn 24, Issue 5, 2003, Pages 269-276

  Athauda, Senarath B P ^a,b,c   Nomura, Hiroyuki ^a,d   Inoue, Hideshi ^a   Takahashi, Kenji ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b UNIVERSITY OF PERADENIYA   (Sri Lanka)

^c INSTITUTE OF FUNDAMENTAL STUDIES   (Sri Lanka)

^d AOYAMA GAKUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC PROTEINASE; COMPLEMENTARY DNA;

AMINO ACID SEQUENCE; ARTICLE; BRUGIA MALAYI; CONTROLLED STUDY; ENZYME LOCALIZATION; ESOPHAGUS; FILARIA; FILARIASIS; GENITAL SYSTEM; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE; LYMPHATIC SYSTEM INFECTION; MOLECULAR CLONING; MUSCLE TISSUE; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE; PHYLOGENY; PROTEIN FAMILY; PROTEIN FUNCTION; TISSUE DISTRIBUTION;

BRUGIA MALAYI; FILARIA; NEMATODA;

EID: 27244458826     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.24.269     Document Type: Article

References (21)

1. Altschul S. F., Gish W., Miller W., Myers E. W. and Lipman D. J. (1990) Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
2. Brindley P. J., Kalinna B. H. and Dalton J. P. (1997) Proteolytic degradation of host haemoglobin by schistosomes. Mol. Biochem. Parasitol. 89, 1-9.
3. Dame J. B., Reddy G. R., Yowell C. A, Dunn B. M, Kay J. and Berry C. (1994) Sequence, expression and modeled structure of an aspartic protease from the human malaria parasite Plasmodium falciparum. Mol. Biochem. Parasitol. 164, 177-190.
4. Faust P. L., Kornfeld S. and Chirgwin J. M. (1985) Cloning and sequence analysis of cDNA for human cathepsin D. Proc. Natl. Acad. Sci. USA 82, 4910-4914.
5. Finney, M. and Ruvkun, G. B. (1990) The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63, 895-905.
6. Gallego S. G, Slade R. W. and Brindley J. P (1998) A cDNA encoding a pepsinogen-like aspartic protease from the human roundworm parasite Strongyloides stercoralis. Acta Tropica 71, 17-26.
7. Geier, G., Banaj, H.-J., Heid, H., Bini, L., Pallini, V. and Zwilling, R. (1999) Aspartyl proteases in Caenorhabditis elegans. Isolation, identification and characterization by a combined use of affinity chromatography, two-dimensional gel electrophorsis, microsequencing and data bank analysis. Eur. J. Biochem. 264, 872-879.
8. Harrop S. A, Prociv P. and Brindley P. J. (1996) Acasp, a gene encoding a cathepsin D-like aspartic protease expressed by adult Ancylostoma caninum hookworms. Biochem. Biophys. Res. Commun. 227, 294-302.
9. Jolodar A. and Miller D. J. (1998) Identification of a novel family of non-lysosomal aspartic proteases in nematodes. Biochim. Biophys. Acta 1382, 13-16.
10. Kageyama T. and Takahashi K. (1986) The complete amino acid sequence of monkey progastricsin. J. Biol. Chem. 261, 4406-4419.
11. Longbottom D., Redmond D. L., Russell M., Liddell S., Smith W. D. and Knox D. P. (1997) Molecular cloning and characterization of a putative aspartic protease associated with a gut membrane protein complex from adult Haemonchus contortus. Mol. Biochem. Parasotol. 88, 63-72.
12. Michael E. and Bundy D. A. P. (1997) Global mapping of lymphatic filariasis. Parasitol. Today 13, 472-476.
13. Sielecki, A. R., Fedorov, A. A., Boodhoo, A., Andreeva, N. S. and James, M. N. G. (1990) Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 Å resolution. J. Mol. Biol. 214, 143-170.
14. Syntichaki, P., Xu K., Driscoll, M. and Tavernarakis N. (2002) Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature 419, 939-944.
15. Takacs A. M., Denker J. A., Perrine K. G., Maroney P. A. and Nilsen T. W. (1988) A 22-nucleotide spliced leader sequence in the human parasitic nematode Brugia malayi is identical to the trans-spliced leader exon in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 85, 7932-7936.
16. Tcherepanova I., Bhattacharyyas L., Rubin S. C. and Freedman, J. H. (2000) Aspartic protease from the nematode Caenorhabditis elegans: Structural organization and developmental and cell-specific expression of asp-1. J. Biol. Chem. 275, 26359-26469.
17. Thompson J. D., Higgins D. G. and Gibson T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position specific gap penalties and weight matrix choice. Nucl. Acids Res. 22, 4673-4680.
18. Tort J., Brindley P. J., Knox D., Wolfe K. H. and Dalton J. P. (1999) Proteases and associated genes of parasitic helminths. Adv. Parasitol. 43, 161-266.
19. von Heijne G. (1986) A new method for predicting signal sequence cleavage sites. Nucl. Acid Res. 14, 4683-4690.
20. Williams S. A., Lizotte-Waniewski M. R., Guiliano D., Daub J., Scott A. L., Slatko B. and Blaxter M. L. (2000) The filarial genome project: analysis of the nuclear, mitochondrial and endosymbiont genomes of Brugia malayi. Int. J. Parasitol. 30, 411-419.
21. Yasuda Y., Ikeda S., Sakai H., Tsukuba T., Okamoto K., Nishisita K., Akamine A., Kato Y. and Yamamoto K. (1999) Role of N-glycosylation in cathepsin E. A comparative study of cathepsin E with distinct N-linked oligosaccharides and its nonglycosylated mutant. Eur. J. Biochem. 266, 383-391.