The effect of ethanol on the physical properties of neuronal membranes

Molecules and Cells

Volumn 19, Issue 3, 2005, Pages 356-364

  Bae, Moon Kyoung ^a   Jeong, Dong Keun ^a   Park, No Soo ^a   Lee, Cheol Ho ^a   Cho, Bong Hye ^a   Jang, Hye Ock ^a   Yun, Il ^a  

^a Pusan National University   (South Korea)

Author keywords

Annular Lipid Fluidity; Ethanol; Membrane Protein Clustering; Transbilayer Lateral And Rotational Mobility

Indexed keywords

1,3 DI(1 PYRENYL) PROPANE; 1,6 DIPHENYL 1,3,5 HEXATRIENE; ALCOHOL; PROPANE; TRINITROPHENYL; TRYPTOPHAN; UNCLASSIFIED DRUG; 1,3 DI (1 PYRENYL)PROPANE; 1,3-DI-(1-PYRENYL)PROPANE; FLUORESCENT DYE; MEMBRANE PROTEIN; PYRENE DERIVATIVE; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; COW; ENERGY TRANSFER; FLUORESCENCE ANALYSIS; LIPID BILAYER; MEMBRANE VESICLE; NERVE CELL MEMBRANE; NONHUMAN; PROTEIN LOCALIZATION; SYNAPTIC MEMBRANE; ANIMAL; CATTLE; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FLUOROMETRY; MEMBRANE FLUIDITY; SYNAPTOSOME;

ANIMALIA; BOVINAE;

ANIMALS; CATTLE; CELL MEMBRANE; CEREBRAL CORTEX; DIPHENYLHEXATRIENE; ETHANOL; FLUORESCENT DYES; FLUOROMETRY; LIPID BILAYERS; MEMBRANE FLUIDITY; MEMBRANE PROTEINS; PYRENES; SYNAPTOSOMES; TRINITROBENZENESULFONIC ACID;

EID: 27244450015     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Armbrecht, H. J., Wood, W. G., Wise, R. W., Walsh, J. B., Thomas, B. N., et al. (1983) Ethanol-induced disordering of membranes from different age groups of C57BL/6NNIA mice. J. Pharmacol. Exp. Ther. 226, 387-391.
2. Bangham, A. D. and Mason, W. (1979) The effect of some general anesthetics on the surface potential of lipid monolayers. Br. J. Pharmacol. 66, 259-265.
3. Brasaemle, D. L., Robertson, A. D., and Attie, A. D. (1988) Transbilayer movement of cholesterol in the human erythrocyte membrane. J. Lipid Res. 29, 481-489.
4. Chabanel, A., Abbott, R. E., Chien, S., and Schachter, D. (1985) Effects of benzyl alcohol on erythrocyte shape, membrane hemileaflet fluidity and membrane viscoelasticity. Biochim. Biophys. Acta 816, 142-152.
5. Chin, J. H. and Goldstein, D. B. (1977a) Effects of low concentrations of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes. Mol. Pharmacol. 13, 435-441.
6. Chin, J. H. and Goldstein, D. B. (1977b) Drug tolerance in biomembranes: a spin label study of the effects of ethanol. Science 196, 684-685.
7. Chin, J. H. and Goldstein, D. B. (1981) Membrane-disordering action of ethanol: variation with membrane cholesterol content and depth of the spin label probe. Mol. Pharmacol. 19, 425-431.
8. Chin, J. H. and Goldstein, D. B. (1984) Cholesterol blocks the disordering effects of ethanol in biomembranes. Lipids 19, 929-935.
9. Cogan, U. and Schachter, D. (1981) Asymmetry of lipid dynamics in human erythrocyte membranes studied with impermeant fluorophores. Biochemistry 20, 6396-6403.
10. Curry, S., Lieb, W. R., and Franks, N. P. (1990) Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity. Biochemistry 29, 4641-4652.
11. Curtain, C. C., Gordon, L. M., and Aloia, R. C. (1988) The role of cholesterol in regulating membrane fluidity; in Advances in Membrane Fluidity, Aloia, R. L., Curtain, C. C., and Gofron, L. M. (eds.), Vol. 2, pp. 1-15, Alan R Liss, New York.
12. Dicknson, R., Smith, E. H., Franks, N. P., and Lieb, W. R. (1993a) Synthesis and use of the n-bromododecane-1,12-diols as conformational probes for general anesthetic target sites. J. Med. Chem. 36, 111-118.
13. Dicknson, R., Franks, N. P., and Lieb, W. R. (1993b) Thermodynamics of anesthetics/protein interactions. Temperature studies on firefly luciferase. Biophys. J. 64, 1264-1271.
14. Dobretsov, G. E., Spirin, M. M., Chekrygin, O. V., Karamansky, I. M., Dmitriev, V. M., et al. (1982) A fluorescence study of apolipoprotein localization in relation to lipids in serum low density lipoproteins. Biochim. Biophys. Acta 710, 172-180.
15. Franks, N. P. and Lieb, W. R. (1985) Mapping of general anesthetic target sites provides a molecular basis for cutoff effects. Nature 316, 349-351.
16. Franks, N. P. and Lieb, W. R. (1987) Neuron membranes: anesthetics on the mind. Nature 328, 113-114.
17. Franks, N. P. and Lieb, W. R. (1993) Do general anesthetics act by competitive binding to specific receptors? Nature 310, 599-601.
18. Franks, N. P. and Lieb, W. R. (1994) Molecular and cellular mechanisms of general anesthesia. Nature 367, 607-614.
19. Goldstein, D. B. and Chin, J. H. (1981) Interaction of ethanol with biological membranes. Fed. Proc. 40, 2073-2076.
20. Gonzales, R. A. and Hoffman, P. L. (1991) Receptor-gated ion channels may be selective CNS targets for ethanol. Trends Pharmacol. Sci. 12, 1-3.
21. Jang, H. O., Jeong, D. K., Ahn, S. H., Yoon, C. D., Jeong, S. C., et al. (2004a) Effects of chlorpromazine·HCl on the structural parameters of bovine brain membranes. J. Biochem. Mol. Biol. 37, 603-611.
22. Jang, H. O., Shin, H. G., and Yun, I. (2004b) Effects of dimyristoylphosphatidylethanol on the structural parameters of neuronal membrane. Mol. Cells 17, 485-491.
23. Janoff, A. S., Boni, L. T., and Rauch, J. (1988) Phase-defined domain in biological membranes: a perspective; in Advanes in Membrane Fluidity, Aloia, R. C., Curtain, C. C., and Gordon, L. M. (eds.), Vol. 2, pp. 101-109, Alan R. Liss, New York.
24. Kang, J.-S., Choi, Ch.-M., and Yun, I. (1996) Effects of ethanol on lateral and rotational mobility of plasma membrane vesicles isolated from cultured mouse myeloma cell line Sp2/0-Ag14. Biochim. Biophys. Acta 1281, 157-163.
25. Kier, A. B., Sweet, W. D., Cowlen, M. S., and Schroeder, F. (1986) Regulation of transbilayer distribution of a fluorescent sterol in tumor cell plasma membranes. Biochim. Biophys. Acta 861, 287-301.
26. Kirsch, P., Hafner, M., Zentgraf, H., and Schilling, L. (2003) Time course of fluorescence intensity and protein expression in HeLa cells stably transfected with hrGFP. Mol. Cells 15, 341-348.
27. Lowry, O. H., Rosebrough, N. R., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Folin reagent. J. Biol. Chem. 193, 265-275.
28. Manevich, E. M., Koiv, A., Jarv, J., Molotkovsky, J. G., and Bergelson, L. D. (1988) Binding of specific ligands to muscarinic receptors alters the fluidity of membrane fragments from rat brain. A fluorescence polarization study with lipid-specific probes. FEBS Lett. 236, 43-46.
29. Moss, G. W. J., Franks, N. P., and Lieb, W. R. (1991a) Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase. Proc. Natl. Acad. Sci. USA 88, 134-138.
30. Moss, G. W. J., Lieb, W. R., and Franks, N. P. (1991b) Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal. Biophys. J. 60, 1309-1314.
31. Sanna, E., Concas, A., Serra, M., Santoro, G., and Biggio, G. (1991) Ex vivo binding of t-[35S]butylbicyclophosphorothionate: a biochemical tool to study the pharmacology of ethanol at the gamma-aminobutyric acid-coupled chloride channel. J. Pharmacol. Exp. Ther. 256, 922-928.
32. Schachter, D. (1984) Fluidity and function of hepatocyte plasma membranes. Hepatology 4, 140-151.
33. Schachter, D., Abbott, R. E., Cogan, U., and Flamm, M. (1983) Lipid fluidity of the individual hemileaflets of human erythrocyte membranes. Ann. N. Y. Acad. Sci. 414, 19-28.
34. Schroeder, F., Morrison, W. J., Gorka, C., and Wood, W. G. (1988) Transbilayer effects of ethanol on fluidity of brain membranes leaflets. Biochim. Biophys. Acta 946, 85-94.
35. Schroeder, F., Nemecz, G., Wood, W. G., Joiner, C., Morrot, G., et al. (1991) Transmembrane distribution of sterol in the human erythrocyte. Biochim. Biophys. Acta 1066, 183-192.
36. Seigneuret, M., Zachowski, A., Hermann, A., and Devaux, P. F. (1984) Asymmetric lipid fluidity in human erythrocyte membrane: new spin-label evidence. Biochemistry 23, 4271-4275.
37. Stubbs, C. D. and Williams, B. W. (1992) Fluorescence in membranes; in Fluorescence Spectroscopy in Biochemistry, Lakowicz, J. R. (ed.). Vol. 3, pp. 231-263, Plenum Press, New York.
38. Wood, W. G., Gorka, C., and Schroeder, F. (1989) Acute and chronic effects of ethanol on transbilayer membrane domains. J. Neurochem. 52, 1925-1930.
39. Wood, W. G., Schroeder, F., Hogy, L., Rao, A. M., and Nemecz, G. (1990) Asymmetric distribution of a fluorescent sterol in synaptic plasma membranes: effects of chronic ethanol consumption. Biochim. Biophys. Acta 1025, 243-246.
40. Yun, I. and Kang, J.-S. (1990) The general lipid composition and aminophospholipid asymmetry of synaptosomal plasma membrane vesicles isolated from bovine cerebral cortex. Mol. Cells 1, 15-20.
41. Yun, I., Kim, Y.-S., Yu, S.-H., Chung, I.-K., Kim, I.-S., et al. (1990) Comparison of several procedures for the preparation of synaptosomal plasma membrane vesicles. Arch. Pharm. Res. 13, 325-329.
42. Yun, I., Yang, M.-S., Kim, I.-S., and Kang, J.-S. (1993) Bulk vs. transbilayer effects of ethanol on the fluidity of the plasma membrane vesicles of cultured Chinese hamster ovary cells. Asia Pacific J. Pharmacol. 8, 9-16.
43. Yun, I., Lee, S.-H., and Kang, J.-S. (1994) Effects of ethanol on lateral and rotational mobility of plasma membrane vesicles isolated from cultured Mar 18.5 hybridoma cells. J. Membr. Biol. 138, 221-227.
44. Zachariasse, K. A., Vaz, W. L. C., Stomayer, C., and Kuhnle, W. (1982) Investigation of human erythrocyte ghost membranes with intramolecular excimer probes. Biochim. Biophys. Acta 688, 323-332.