Onset of steroid-induced osteonecrosis in rabbits and its relationship to hyperlipaemia and increased free fatty acids

Rheumatology

Volumn 44, Issue 10, 2005, Pages 1233-1237

  Kabata, T ^a   Kubo, T ^c   Matsumoto, T ^b   Hirata, T ^c   Fujioka, M ^c   Takahashi, K A ^c   Yagishita, S ^a   Kobayashi, M ^a   Tomita, K ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Animal model; Free fatty acids; Hyperlipaemia; Osteonecrosis; Steroid

Indexed keywords

CHOLESTEROL; FATTY ACID; LIPID; METHYLPREDNISOLONE; STEROID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE NECROSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG DOSE REGIMEN; FAT EMBOLISM; FEMALE; FEMUR; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; LIPID BLOOD LEVEL; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCOCORTICOIDS; HYPERLIPIDEMIAS; METHYLPREDNISOLONE; OSTEONECROSIS; RABBITS; TIME FACTORS;

EID: 27144557226     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keh721     Document Type: Article

References (20)

1. Fisher DE, Bickel WH. Corticosteroid-induced avascular necrosis. J Bone Joint Surg 1971;53A:859-73.
2. Mont MA, Hungerford DS. Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg 1995;77A:459-74.
3. Mankin HJ. Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med 1992;326:1473-9.
4. Chang CC, Greenspan A, Gershwin ME. Osteonecrosis: Current perspectives on pathogenesis and treatment. Semin Arthritis Rheum 1993;23:47-69.
5. Fisher DE. The role of fat embolism in the etiology of corticosteroid-induced avascular necrosis. Clin Orthop 1978;130:68-80.
6. Jones JP, Engleman EP, Steinbach HL et al. Fat embolization as a possible mechanism producing avascular necrosis. Arthritis Rheum 1965;8:449.
7. Jones JP. Fat embolism and osteonecrosis. Orthop Clin North Am 1985;16:595-633.
8. Wang GJ, Sweet DE, Reger SI et al. Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits. J Bone Joint Surg 1977;59A:729-35.
9. Zalavras C, Dailiana Z, Elisaf M et al. Potential aetiological factors concerning the development of osteonecrosis of the femoral head. Eur J Clin Invest 2000;30:215-21.
10. Yamamoto T, Irisa T, Sugioka Y et al. Effects of pulse methylprednisolone on bone and marrow tissues. Arthritis Rheum 1997; 40:2055-64.
11. Cui Q, Wang GJ, Su CC et al. Lovastatin prevents steroid induced adipogenesis and osteonecrosis. Clin Orthop 1997; 344:8-19.
12. Kabata T, Kubo T, Matsumoto T et al. Apoptotic cell death in steroid-induced osteonecrosis: An experimental study in rabbits. J Rheumatol 2000;27:166-71.
13. Chernetsky SG, Mont MA, LaPorte DM et al. Pathologic features in steroid and nonsteroid associated osteonecrosis. Clin Orthop 1999; 368:149-61.
14. Matsui M, Saito S, Ohzono K et al. Experimental steroid-induced osteonecrosis in adult rabbits with hypersensitivity vasculitis. Clin Orthop 1992;277:61-72.
15. Yamamoto T, Hirano K, Tsutsui H et al. Corticosteroid enhances the experimental induction of osteonecrosis in rabbits with Shwartzman reaction. Clin Orthop 1995;316:235-43.
16. Kubo T, Yamazoe S, Sugano N et al. Initial MRI findings of non-traumatic osteonecrosis of the femoral head in renal allograft recipients. Magn Reson Imaging 1997;9:1017-23.
17. Sugano N, Ohzono K, Masuhara K et al. Prognostication of osteonecrosis of the femoral head in patients with systemic lupus erythematosus by magnetic resonance imaging. Clin Orthop 1994;305:190-9.
18. Inoue A, Ono K. A histological study of idiopathic avascular necrosis of the head of the femur. J Bone Joint Surg Br 1979;61:138-43.
19. Saito S, Ohzono K, Ono K. Early arteriopathy and postulated pathogenesis of osteonecrosis of the femoral head. Clin Orthop 1992; 277:98-110.
20. Yamamoto T, DiCarlo EF, Bullough PG. The prevalence and clinicopathological appearance of extension of osteonecrosis in the femoral head. J Bone Joint Surg Br 1999;81:328-32.