Angiogenic therapy for bronchopulmonary dysplasia: Rationale and promise

Circulation

Volumn 112, Issue 16, 2005, Pages 2383-2385

  Stenmark, Kurt R ^a   Balasubramaniam, Vivek ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Angiogenesis; Editorials; Gene therapy; Morphogenesis; Pediatrics

Indexed keywords

ADENOVIRUS VECTOR; NITRIC OXIDE; STEROID; SURFACTANT; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; CLINICAL FEATURE; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; EDITORIAL; GENE TRANSFER; HUMAN; LUNG ALVEOLUS; LUNG DEVELOPMENT; LUNG DYSPLASIA; LUNG GAS EXCHANGE; MORPHOGENESIS; NEWBORN CARE; NONHUMAN; PREMATURE LABOR; PRENATAL CARE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; VIRAL GENE DELIVERY SYSTEM;

ANGIOGENESIS INDUCING AGENTS; BRONCHOPULMONARY DYSPLASIA; GENE THERAPY; HUMANS; INFANT, NEWBORN; PULMONARY ALVEOLI; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 27144547278     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.574061     Document Type: Editorial

References (27)

1. Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease: bronchopulmonary dysplasia. N Engl J Med. 1967;276:357-368.
2. Coalson J. Pathology of Chronic Lung Disease of Early Infancy. New York. NY: Marcel Dekker; 1999.
3. Husain AN, Siddiqui NH, Stocker JT. Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia. Hum Pathol. 1998;29:710-717.
4. Jobe AJ. The new BPD: an arrest of lung development. Pediatr Res. 1999;46:641-643.
5. Burri P. Structural Aspects of Prenatal and Postnatal Development and Growth for the Lung. New York, NY: Marcel Dekker; 1997.
6. Gebb SA, Jones PL. Hypoxia and lung branching morphogenesis. Adv Exp Med Biol. 2003;543:117-125.
7. Stenmark KR, Abman SH. Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia. Annu Rev Physiol. 2005;67:623-661.
8. Young SL, Evans K, Eu JP. Nitric oxide modulates branching morphogenesis in fetal rat lung explants. Am J Physiol Lung Cell Mol Physiol. 2002;282:L379-L385.
9. Shannon J, Deterding R. Epithelial-Mesenchymal Interactions in Lung Development. New York, NY: Marcel Dekker; 1997.
10. Baldwin HS. Early embryonic vascular development. Cardiovasc Res. 1996;31:E34-E45.
11. Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM. Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung. Am J Respir Cell Mol Biol. 1997;16:557-567.
12. Hosford GE, Olson DM. Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2003;285:L161-L168.
13. McGrath-Morrow SA, Cho C, Cho C, Zhen L, Hicklin DJ, Tuder RM. Vascular endothelial growth factor receptor 2 blockade disrupts postnatal lung development. Am J Respir Cell Mol Biol. 2005;32:420-427.
14. Jakkula M, Le Cras TD, Gebb S, Hirth KP, Tuder RM, Voelkel NF, Abman SH. Inhibition of angiogenesis decreases alveolarization in the developing rat lung. Am J Physiol Lung Cell Mol Physiol. 2000;279: L600-L607.
15. Lin YJ, Markham NE, Balasubramaniam V, Tang JR, Maxey A, Kinsella JP, Abman SH. Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats. Pediatr Res. 2005;58:22-29.
16. Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004;287:L134-L142.
17. Galambos C, Ng YS, Ali A, Noguchi A, Lovejoy S, D'Amore PA, DeMello DE. Defective pulmonary development in the absence of heparin-binding vascular endothelial growth factor isoforms. Am J Respir Cell Mol Biol. 2002;27:194-203.
18. Tang K, Rossiter HB, Wagner PD, Breen EC. Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol. 2004;97:1559-1566.
19. Thebaud B, Ladha F, Michelakis ED, Sawicka M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL. Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 2005;112:2477-2486.
20. McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, Yoder BA, Kerecman JD, Albertine KH, Winter VT, Coalson JJ, Crapo JD, Grubb PH, Shaul PW. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol. 2005;288:L450-L459.
21. Mestan KK, Marks JD, Hecox K, Huo D, Schreiber MD. Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med. 2005;353:23-32.
22. Van Meurs KP, Wright LL, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK, Perritt R, Higgins RD, Oh W, Hudak ML, Laptook AR, Shankaran S, Finer NN, Carlo WA, Kennedy KA, Fridriksson JH, Steinhorn RH, Sokol GM, Konduri GG, Aschner JL, Stoll BJ, D'Angio CT, Stevenson DK. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med. 2005;353:13-22.
23. Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 2005;105:659-669.
24. Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Gunzler V, White CW. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci USA. 2005;102:10212-10217.
25. Ozer EA, Kumral A, Ozer E, Yilmaz O, Duman N, Ozkal S, Koroglu T, Ozkan H. Effects of erythropoietin on hyperoxic lung injury in neonatal rats. Pediatr Res. 2005;58:38-41.
26. De Paepe ME, Mao Q, Powell J, Rubin SE, DeKoninck P, Appel N, Dixon M, Gundogan F. Growth of the pulmonary microvasculature in ventilated preterm infants. Am J Respir Crit Care Med. In press.
27. Acherman RJ, Siassi B, Pratti-Madrid G, Luna C, Lewis AB, Ebrahimi M, Castillo W, Kamat P, Ramanathan R. Systemic to pulmonary collaterals in very low birth weight infants: color Doppler detection of systemic to pulmonary connections during neonatal and early infancy period. Pediatrics. 2000;105:528-532.