Reduced vascular reactivity after chronic nitroglycerine administration: EDHF mechanism is also downregulated

British Journal of Pharmacology

Volumn 146, Issue 4, 2005, Pages 479-480

  Von Der Weid, Pierre Yves ^a   Coleman, Harold A ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b MONASH UNIVERSITY   (Australia)

Author keywords

EDHF; Endothelium dependent hyperpolarization; Membrane potential; Nitrate tolerance; Superoxide

Indexed keywords

ASCORBIC ACID; CALCIUM ACTIVATED POTASSIUM CHANNEL; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GLYCERYL TRINITRATE; NITRIC OXIDE; VASODILATOR AGENT;

ACUTE HEART INFARCTION; ANGINA PECTORIS; AORTA VALVE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DISEASE; CONGESTIVE HEART FAILURE; DOWN REGULATION; DRUG TOLERANCE; ENDOTHELIUM CELL; HUMAN; HYPERPOLARIZATION; NOTE; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL FACTORS; DOWN-REGULATION; DRUG TOLERANCE; ENDOTHELIAL CELLS; MEMBRANE POTENTIALS; NITROGLYCERIN; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RABBITS; VASODILATOR AGENTS;

EID: 27144515329     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706364     Document Type: Note

References (15)

1. ALLEN, T., IFTINCA, M., COLE, W.C. & PLANE, F. (2002). Smooth muscle membrane potential modulates endothelium-dependent relaxation of rat basilar artery via myo-endothelial gap junctions. J. Physiol., 545, 975-986.
2. BAUERSACHS, J., POPP, R., HECKER, M., SAUER, E., FLEMING, I. & BUSSE, R. (1996). Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation, 94, 3341-3347.
3. CHEN, G., SUZUKI, H. & WESTON, A.H. (1988). Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br. J. Pharmacol., 95, 1165-1174.
4. CHUNG, S.J. & FUNG, H.L. (1990). Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary smooth muscle cells. J. Pharmacol. Exp. Ther., 253, 614-619.
5. COLEMAN, H.A., TARE, M. & PARKINGTON, H.C. (2004). Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease. Clin. Exp. Pharmacol. Physiol., 31, 641-649.
6. EDWARDS, G., DORA, K.A., GARDENER, M.J., GARLAND, C.J. & WESTON, A.H. (1998). K+ is an endothelium-derived hyperpolarizing factor in rat arteries. Nature, 396, 269-272.
7. GORI, T. & PARKER, J.D. (2002). Nitrate tolerance: a unifying hypothesis. Circulation, 106, 2510-2513.
8. G-nitro-L-arginine in pulmonary hypertension. Br. J. Pharmacol., 116, 2457-2467.
9. KUSAMA, N., KAJIKURI, J., YAMAMOTO, T., WATANABE, Y., SUZUKI, Y., KATSUYA, H. & ITOH, T. (2005). Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitoglycerine administration. Br. J. Pharmacol., 146, 487-497 (in this issue).
10. MARCHENKO, S.M. & SAGE, S.O. (1994). Smooth muscle cells affect endothelial membrane potential in rat aorta. Am. J. Physiol., 267, H804-H811.
11. MUNZEL, T. (2001). Does nitroglycerin therapy hit the endothelium? J. Am. Coll. Cardiol., 38, 1102-1105.
12. MUNZEL, T., SAYEGH, H., FREEMAN, B.A., TARPEY, M.M. & HARRISON, D.G. (1995). Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J. Clin. Invest., 95, 187-194.
13. SANDOW, S.L., TARE, M., COLEMAN, H.A., HILL, C.E. & PARKINGTON, H.C. (2002). Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor. Circ. Res., 90, 1108-1113.
14. VON DER WEID, P.-Y. & BÉNY, J.L. (1993). Simultaneous oscillations in the membrane potential of pig coronary artery endothelial and smooth muscle cells. J. Physiol. (London), 471, 13-24.
15. WESTON, A.H., FELETOU, M., VANHOUTTE, P.M., FALCK, J.R., CAMPBELL, W.B. & EDWARDS, G. (2005). Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br. J. Pharmacol., 145, 775-784.