Na+-K+ pump activation inhibits endothelium-dependent relaxation by activating the forward mode of Na+/Ca2+ exchanger in mouse aorta

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 5 58-5, 2005, Pages

  Kim, Moon Young ^a   Seol, Geun Hee ^a   Liang, Guo Hua ^a   Kim, Ji Aee ^a   Suh, Suk Hyo ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Endothelial cells; Extracellular potassium; Forward mode of sodium calcium exchanger; Intracellular calcium; Sodium potassium pump

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CYCLIC GMP; DICHLOROBENZAMIL; ENDOTHELIUM DERIVED RELAXING FACTOR; MONENSIN; OUABAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EVOKED RESPONSE; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SODIUM CALCIUM EXCHANGE; STIMULUS RESPONSE; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASOMOTOR REFLEX;

ANIMALS; AORTA, THORACIC; CYCLIC AMP; ENDOTHELIUM, VASCULAR; FEMALE; IONOPHORES; MALE; MICE; MONENSIN; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NA(+)-K(+)-EXCHANGING ATPASE; NICKEL; OUABAIN; POTASSIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SODIUM; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 27144490332     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00908.2004     Document Type: Article

References (29)

1. + current in mouse aortic endothelial cells. Pflügers Arch 447: 426-435, 2004.
2. Balzer M, Lintschinger B, and Groschner K. Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells. Cardiovasc Res 42: 543-549, 1999.
3. + concentration in internally perfused cardiac cells. Biochim Biophys Acta 1065: 269-271, 1991.
4. Bouloumie A, Bauersachs J, Linz W, Scholkens BA, Wiemer G, Fleming I, and Busse R. Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production. Hypertension 30: 934-941, 1997.
5. + channel in porcine coronary artery endothelium: relevance to EDHF. Br J Pharmacol 135: 1133-1143, 2002.
6. 2+ exchange and its implications for calcium homeostasis in primary cultured rat brain microvascular endothelial cells. J Physiol 515: 147-155, 1999.
7. + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 396: 269-272, 1998.
8. Elliott SJ and Koliwad SK. Oxidant stress and endothelial membrane transport. Free Radic Biol Med 19: 649-658, 1995.
9. 2+ exchange mediation in the ouabain-induced contraction in human placental vessels. Gen Pharmacol 23: 439-444, 1992.
10. i in a restricted space of guinea-pig ventricular cells. J Physiol 509: 457-470, 1998.
11. 2+ elevation beneath the cell membrane. J Physiol 506: 109-125, 1998.
12. Ischiropoulos H, Zhu L, and Beckman JS. Peroxynitrite formation from macrophage-derived nitric oxide. Arch Biochem Biophys 298: 446-451, 1992.
13. 2+ exchange in cells expressing NCX1. J Biol Chem 271: 22391-22397, 1996.
14. + pump and KIR currents to extracellular pH-dependent changes of contractility in rat superior mesenteric artery. Am J Physiol Heart Circ Physiol 289: H792-H800, 2005.
15. Koppenol WH, Moreno JJ, Pryor WA, Ischiropoulos H, and Beckman JS. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem Res Toxicol 5: 834-842, 1992.
16. 2+ exchange in intact endothelium of rabbit cardiac valve. Circ Res 76: 396-404, 1995.
17. Manolopoulos VG, Liu J, Unsworth BR, and Lelkes PI. Adenylyl cyclase isoforms are differentially expressed in primary cultures of endothelial cells and whole tissue homogenates from various rat tissues. Biochem Biophys Res Commun 208: 323-331, 1995.
18. Marin J, Fernandez-Alfonso MS, and Sanchez-Ferrer CF. Sodium pump activity and contractile effect of ouabain in human placental veins. Eur J Pharmacol 201: 75-82, 1991.
19. McCarron JG and Halpern W. Potassium dilates rat cerebral arteries by two independent mechanisms. Am J Physiol Heart Circ Physiol 259: H902-H908, 1990.
20. Muijsers RB, Folkerts G, Henricks PA, Sadeghi-Hashjin G, and Nijkamp FP. Peroxynitrite: a two-faced metabolite of nitric oxide. Life Sci 60: 1833-1845, 1997.
21. Munzel T, Heitzer T, and Harrison DG. The physiology and pathophysiology of the nitric oxide/superoxide system. Herz 22: 158-172, 1997.
22. Nilius B and Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol Rev 81: 1415-1459, 2001.
23. 2+ channels. Neuropharmacology 48: 566-575, 2005.
24. Paulson OB and Newman EA. Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science 237: 896-898, 1987.
25. + exchanger in endothelial NO production and endothelium-dependent relaxation. Am J Physiol Heart Circ Physiol 283: H837-H844, 2002.
26. +: a novel controlling signal for vascular contractility. Am J Physiol Heart Circ Physiol 286: H329-H339, 2004.
27. 2+ signalling. Pflügers Arch 438: 612-620, 1999.
28. 2+-dependent activation of endothelial nitric-oxide synthase. J Biol Chem 274: 29529-29535, 1999.
29. Woolfson RG and Poston L. Effect of ouabain on endothelium-dependent relaxation of human resistance arteries. Hypertension 17: 619-625, 1991.