Genetic targeting strategies for adenovirus

Molecular Pharmaceutics

Volumn 2, Issue 5, 2005, Pages 341-347

  Noureddini, Sam C ^a   Curiel, David T ^b,c  

^a VectorLogics Inc   (United States)

^b University of Alabama at Birmingham   (United States)

^c UAB Gene Therapy Center   (United States)

Author keywords

Adenovirus; Gene therapy; Gene transfer; Review; Target cell

Indexed keywords

ADENOVIRUS VECTOR; CAPSID PROTEIN; CAPSID PROTEIN IX; CARCINOEMBRYONIC ANTIGEN; HYBRID PROTEIN; LIGAND; RECEPTOR; UNCLASSIFIED DRUG;

ADENOVIRUS 5; BIOLOGY; CHIMERA; GENE TARGETING; GENE TRANSFER; GENETIC ENGINEERING; GENETIC MANIPULATION; GENETIC TRANSDUCTION; IN VIVO STUDY; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEROTYPE; TARGET ORGAN; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS CAPSID;

ADENOVIRIDAE; GENE THERAPY; GENETIC VECTORS; HUMANS; ORGAN SPECIFICITY;

EID: 27144482675     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp050045c     Document Type: Review

References (58)

1. McLay, R. N.; Daylo, A.; Hammer, P. S. Predictors of Length of Stay in a Psychiatric Ward Serving Active Duty Military and Civilian Patients. Mil. Med. 2005, 170, 219-22.
2. Volpers, C.; Kochanek, S. Adenoviral Vectors for Gene Transfer and Therapy. J. Gene Med. 2004, 6 (Suppl. 1), S164-71.
3. Saukkonen, K.; Hemminki, A. Tissue-Specific Promoters for Cancer Gene Therapy. Expert Opin. Biol. Ther. 2004, 4, 683-96.
4. Mizuguchi, H.; Hayakawa, T. Targeted Adenovirus Vectors. Hum. Gene Ther. 2004, 15, 1034-44.
5. Everts, M.; Curiel, D. T. Transductional Targeting of Adenoviral Cancer Gene Therapy. Curr. Gene Ther. 2004, 4, 337-46.
6. Henry, L. J.; Xia, D.; Wilke, M. E.; Deisenhofer, J.; Gerard, R. D. Characterization of the Knob Domain of the Adenovirus Type 5 Fiber Protein Expressed in Escherichia Coli. J. Virol. 1994, 68, 5239-46.
7. Bergelson, J. M.; Cunningham, J. A.; Droguett, G.; Kurt-Jones, E. A.; Krithivas, A.; Hong, J. S.; Horwitz, M. S.; Crowell, R. L.; Finberg, R. W. Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5. Science 1997, 275, 1320-3.
8. Hong, J. S.; Engler, J. A. Domains Required for Assembly of Adenovirus Type 2 Fiber Trimers. J. Virol. 1996, 70, 7071-8.
9. Louis, N.; Fender, P.; Barge, A.; Kitts, P.; Chroboczek, J. Cell-Binding Domain of Adenovirus Serotype 2 Fiber. J. Virol. 1994, 68, 4104-6.
10. Gall, J.; Kass-Eisler, A.; Leinwand, L.; Falck-Pedersen, E. Adenovirus Type 5 and 7 Capsid Chimera: Fiber Replacement Alters Receptor Tropism without Affecting Primary Immune Neutralization Epitopes. J. Virol. 1996, 70, 2116-23.
11. Shayakhmetov, D. M.; Papayannopoulou, T.; Stamatoyannopoulos, G.; Lieber, A. Efficient Gene Transfer into Human Cd34(+) Cells by a Retargeted Adenovirus Vector. J. Virol. 2000, 74, 2567-83.
12. Goossens, P. H.; Havenga, M. J.; Pieterman, E.; Lemckert, A. A.; Breedveld, F. C.; Bout, A.; Huizinga, T. W. Infection Efficiency of Type 5 Adenoviral Vectors in Synovial Tissue Can Be Enhanced with a Type 16 Fiber. Arthritis Rheum. 2001, 44, 570-7.
13. Havenga, M. J.; Lemckert, A. A.; Grimbergen, J. M.; Vogels, R.; Huisman, L. G.; Valerio, D.; Bout, A.; Quax, P. H. Improved Adenovirus Vectors for Infection of Cardiovascular Tissues. J. Virol. 2001, 75, 3335-42.
14. Krasnykh, V. N.; Mikheeva, G. V.; Douglas, J. T.; Curiel, D. T. Generation of Recombinant Adenovirus Vectors with Modified Fibers for Altering Viral Tropism. J. Virol. 1996, 70, 6839-46.
15. Kanerva, A.; Mikheeva, G. V.; Krasnykh, V.; Coolidge, C. J.; Lam, J. T.; Mahasreshti, P. J.; Barker, S. D.; Straughn, M.; Barnes, M. N.; Alvarez, R. D.; Hemminki, A.; Curiel, D. T. Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells. Clin. Cancer Res. 2002, 8, 275-80.
16. Kawakami, Y.; Li, H.; Lam, J. T.; Krasnykh, V.; Curiel, D. T.; Blackwell, J. L. Substitution of the Adenovirus Serotype 5 Knob with a Serotype 3 Knob Enhances Multiple Steps in Virus Replication. Cancer Res. 2003, 63, 1262-9.
17. Wu, H.; Seki, T.; Dmitriev, I.; Uil, T.; Kashentseva, E.; Han, T.; Curiel, D. T. Double Modification of Adenovirus Fiber with Rgd and Polylysine Motifs Improves Coxsackievirus-Adenovirus Receptor-Independent Gene Transfer Efficiency. Hum. Gene Ther. 2002, 13, 1647-53.
18. Wickham, T. J.; Tzeng, E.; Shears, L. L., 2nd; Roelvink, P. W.; Li, Y.; Lee, G. M.; Brough, D. E.; Lizonova, A.; Kovesdi, I. Increased in Vitro and in Vivo Gene Transfer by Adenovirus Vectors Containing Chimeric Fiber Proteins. J. Virol. 1997, 71, 8221-9.
19. Xia, D.; Henry, L. J.; Gerard, R. D.; Deisenhofer, J. Crystal Structure of the Receptor-Binding Domain of Adenovirus Type 5 Fiber Protein at 1.7 Å Resolution. Structure 1994, 2, 1259-70.
20. Krasnykh, V.; Dmitriev, I.; Mikheeva, G.; Miller, C. R.; Belousova, N.; Curiel, D. T. Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob. J. Virol. 1998, 72, 1844-52.
21. Belousova, N.; Krendelchtchikova, V.; Curiel, D. T.; Krasnykh, V. Modulation of Adenovirus Vector Tropism Via Incorporation of Polypeptide Ligands into the Fiber Protein. J. Virol. 2002, 76, 8621-31.
22. Dmitriev, I.; Krasnykh, V.; Miller, C. R.; Wang, M.; Kashentseva, E.; Mikheeva, G.; Belousova, N.; Curiel, D. T. An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism Via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism. J. Virol. 1998, 72, 9706-13.
23. Hemminki, A.; Belousova, N.; Zinn, K. R.; Liu, B.; Wang, M.; Chaudhuri, T. R.; Rogers, B. E.; Buchsbaum, D. J.; Siegal, G. P.; Barnes, M. N.; Gomez-Navarro, J.; Curiel, D. T.; Alvarez, R. D. An Adenovirus with Enhanced Infectivity Mediates Molecular Chemotherapy of Ovarian Cancer Cells and Allows Imaging of Gene Expression. Mol. Ther. 2001, 4, 223-31.
24. Hemminki, A.; Zinn, K. R.; Liu, B.; Chaudhuri, T. R.; Desmond, R. A.; Rogers, B. E.; Barnes, M. N.; Alvarez, R. D.; Curiel, D. T. In Vivo Molecular Chemotherapy and Noninvasive Imaging with an Infectivity-Enhanced Adenovirus. J. Natl. Cancer Inst. 2002, 94, 741-9.
25. Bauerschmitz, G. J.; Barker, S. D.; Hemminki, A. Adenoviral Gene Therapy for Cancer: From Vectors to Targeted and Replication Competent Agents (Review). Int. J. Oncol. 2002, 21, 1161-74.
26. Nicklin, S. A.; Reynolds, P. N.; Brosnan, M. J.; White, S. J.; Curiel, D. T.; Dominiczak, A. F.; Baker, A. H. Analysis of Cell-Specific Promoters for Viral Gene Therapy Targeted at the Vascular Endothelium. Hypertension 2001, 38, 65-70.
27. Nicklin, S. A.; White, S. J.; Watkins, S. J.; Hawkins, R. E.; Baker, A. H. Selective Targeting of Gene Transfer to Vascular Endothelial Cells by Use of Peptides Isolated by Phage Display. Circulation 2000, 102, 231-7.
28. Nicklin, S. A.; Dishart, K. L.; Buening, H.; Reynolds, P. N.; Hallek, M.; Nemerow, G. R.; Von Seggern, D. J.; Baker, A. H. Transductional and Transcriptional Targeting of Cancer Cells Using Genetically Engineered Viral Vectors. Cancer Lett. 2003, 201, 165-73.
29. Work, L. M.; Nicklin, S. A.; Brain, N. J.; Dishart, K. L.; Von Seggern, D. J.; Hallek, M.; Buning, H.; Baker, A. H. Development of Efficient Viral Vectors Selective for Vascular Smooth Muscle Cells. Mol. Ther. 2004, 9, 198-208.
30. Xia, H.; Anderson, B.; Mao, Q.; Davidson, B. L. Recombinant Human Adenovirus: Targeting to the Human Transferrin Receptor Improves Gene Transfer to Brain Microcapillary Endothelium. J. Virol. 2000, 74, 11359-66.
31. Falgout, B.; Ketner, G. Characterization of Adenovirus Particles Made by Deletion Mutants Lacking the Fiber Gene. J. Virol. 1988, 62, 622-5.
32. Von Seggern, D. J.; Chiu, C. Y.; Fleck, S. K.; Stewart, P. L.; Nemerow, G. R. A Helper-Independent Adenovirus Vector with E1, E3, and Fiber Deleted: Structure and Infectivity of Fiberless Particles. J. Virol. 1999, 73, 1601-8.
33. Legrand, V.; Spehner, D.; Schlesinger, Y.; Settelen, N.; Pavirani, A.; Mehtali, M. Fiberless Recombinant Adenoviruses: Virus Maturation and Infectivity in the Absence of Fiber. J. Virol. 1999, 73, 907-19.
34. Magnusson, M. K.; Hong, S. S.; Boulanger, P.; Lindholm, L. Genetic Retargeting of Adenovirus: Novel Strategy Employing "Deknobbing" of the Fiber. J. Virol. 2001, 75, 7280-9.
35. van Beusechem, V. W.; van Rijswijk, A. L.; van Es, H. H.; Haisma, H. J.; Pinedo, H. M.; Gerritsen, W. R. Recombinant Adenovirus Vectors with Knobless Fibers for Targeted Gene Transfer. Gene Ther. 2000, 7, 1940-6.
36. Mercier, G. T.; Campbell, J. A.; Chappell, J. D.; Stehle, T.; Dermody, T. S.; Barry, M. A. A Chimeric Adenovirus Vector Encoding Reovirus Attachment Protein Sigma1 Targets Cells Expressing Junctional Adhesion Molecule 1. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6188-93.
37. Krasnykh, V.; Belousova, N.; Korokhov, N.; Mikheeva, G.; Curiel, D. T. Genetic Targeting of an Adenovirus Vector Via Replacement of the Fiber Protein with the Phage T4 Fibritin. J. Virol. 2001, 75, 4176-83.
38. Belousova, N.; Korokhov, N.; Krendelshchikova, V.; Simonenko, V.; Mikheeva, G.; Triozzi, P. L.; Aldrich, W. A.; Banerjee, P. T.; Gillies, S. D.; Curiel, D. T.; Krasnykh, V. Genetically Targeted Adenovirus Vector Directed to Cd40-Expressing Cells. J. Virol. 2003, 77, 11367-77.
39. Vigne, E.; Mahfouz, I.; Dedieu, J. F.; Brie, A.; Perricaudet, M.; Yeh, P. Rgd Inclusion in the Hexon Monomer Provides Adenovirus Type 5-Based Vectors with a Fiber Knob-Independent Pathway for Infection. J. Virol. 1999, 73, 5156-61.
40. Roelvink, P. W.; Kovesdi, I.; Wickham, T. J. Comparative Analysis of Adenovirus Fiber-Cell Interaction: Adenovirus Type 2 (Ad2) and Ad9 Utilize the Same Cellular Fiber Receptor but Use Different Binding Strategies for Attachment. J. Virol. 1996, 70, 7614-21.
41. Huang, S.; Kamata, T.; Takada, Y.; Ruggeri, Z. M.; Nemerow, G. R. Adenovirus Interaction with Distinct Integrins Mediates Separate Events in Cell Entry and Gene Delivery to Hematopoietic Cells. J. Virol. 1996, 70, 4502-8.
42. Einfeld, D. A.; Brough, D. E.; Roelvink, P. W.; Kovesdi, I.; Wickham, T. J. Construction of a Pseudoreceptor That Mediates Transduction by Adenoviruses Expressing a Ligand in Fiber or Penton Base. J. Virol. 1999, 73, 9130-6.
43. Ghosh-Choudhury, G.; Haj-Ahmad, Y.; Graham, F. L. Protein IX, a Minor Component of the Human Adenovirus Capsid, Is Essential for the Packaging of Full Length Genomes. EMBO J. 1987, 6, 1733-9.
44. Furcinitti, P. S.; van Oostrum, J.; Burnett, R. M. Adenovirus Polypeptide IX Revealed as Capsid Cement by Difference Images from Electron Microscopy and Crystallography. EMBO J. 1989, 8, 3563-70.
45. Akalu, A.; Liebermann, H.; Bauer, U.; Granzow, H.; Seidel, W. The Subgenus-Specific C-Terminal Region of Protein IX Is Located on the Surface of the Adenovirus Capsid. J. Virol. 1999, 73, 6182-7.
46. Dmitriev, I. P.; Kashentseva, E. A.; Curiel, D. T. Engineering of Adenovirus Vectors Containing Heterologous Peptide Sequences in the C Terminus of Capsid Protein IX. J. Virol. 2002, 76, 6893-9.
47. Vellinga, J.; Rabelink, M. J.; Cramer, S. J.; van den Wollenberg, D. J.; Van der Meulen, H.; Leppard, K. N.; Fallaux, F. J.; Hoeben, R. C. Spacers Increase the Accessibility of Peptide Ligands Linked to the Carboxyl Terminus of Adenovirus Minor Capsid Protein IX. J. Virol. 2004, 78, 3470-9.
48. Le, L. P.; Everts, M.; Dmitriev, I. P.; Davydova, J. G.; Yamamoto, M.; Curiel, D. T. Fluorescently Labeled Adenovirus with pIX-EGFP for Vector Detection. Mol. Imaging 2004, 3, 105-16.
49. Meulenbroek, R. A.; Sargent, K. L.; Lunde, J.; Jasmin, B. J.; Parks, R. J. Use of Adenovirus Protein IX (pIX) to Display Large Polypeptides on the Virion-Generation of Fluorescent Virus through the Incorporation of pIX-GFP. Mol. Ther. 2004, 9, 617-24.
50. Li, J.; Le, L.; Sibley, D. A.; Mathis, J. M.; Curiel, D. T. Genetic Incorporation of HSV-1 Thymidine Kinase into the Adenovirus Protein IX for Functional Display on the Virion. Virology 2005.
51. Volpers, C.; Thirion, C.; Biermann, V.; Hussmann, S.; Kewes, H.; Dunant, P.; von der Mark, H.; Herrmann, A.; Kochanek, S.; Lochmuller, H. Antibody-Mediated Targeting of an Adenovirus Vector Modified to Contain a Synthetic Immunoglobulin G-Binding Domain in the Capsid. J. Virol. 2003, 77, 2093-104.
52. Henning, P.; Magnusson, M. K.; Gunneriusson, E.; Hong, S. S.; Boulanger, P.; Nygren, P. A.; Lindholm, L. Genetic Modification of Adenovirus 5 Tropism by a Novel Class of Ligands Based on a Three-Helix Bundle Scaffold Derived from Staphylococcal Protein A. Hum. Gene Ther. 2002, 13, 1427-39.
53. Korokhov, N.; Mikheeva, G.; Krendelshchikov, A.; Belousova, N.; Simonenko, V.; Krendelshchikova, V.; Pereboev, A.; Kotov, A.; Kotova, O.; Triozzi, P. L.; Aldrich, W. A.; Douglas, J. T.; Lo, K. M.; Banerjee, P. T.; Gillies, S. D.; Curiel, D. T.; Krasnykh, V. Targeting of Adenovirus Via Genetic Modification of the Viral Capsid Combined with a Protein Bridge. J. Virol. 2003, 77, 12931-40.
54. Parrott, M. B.; Adams, K. E.; Mercier, G. T.; Mok, H.; Campos, S. K.; Barry, M. A. Metabolically Biotinylated Adenovirus for Cell Targeting, Ligand Screening, and Vector Purification. Mol. Ther. 2003, 8, 688-700.
55. Campos, S. K.; Parrott, M. B.; Barry, M. A. Avidin-Based Targeting and Purification of a Protein IX-Modified, Metabolically Biotinylated Adenoviral Vector. Mol. Ther. 2004, 9, 942-54.
56. Everts, M.; Kim-Park, S. A.; Preuss, M. A.; Passineau, M. J.; Glasgow, J. N.; Pereboev, A. V.; Mahasreshti, P. J.; Grizzle, W. E.; Reynolds, P. N.; Curiel, D. T. Selective Induction of Tumor-Associated Antigens in Murine Pulmonary Vasculature Using Double-Targeted Adenoviral Vectors. Gene Ther., in press.
57. de Gruijl, T. D.; Luykx-de Bakker, S. A.; Tillman, B. W.; van den Eertwegh, A. J.; Buter, J.; Lougheed, S. M.; van der Bij, G. J.; Safer, A. M.; Haisma, H. J.; Curiel, D. T.; Scheper, R. J.; Pinedo, H. M.; Gerritsen, W. R. Prolonged Maturation and Enhanced Transduction of Dendritic Cells Migrated from Human Skin Explants after in Situ Delivery of Cd40-Targeted Adenoviral Vectors. J. Immunol. 2002, 169, 5322-31.
58. Korokhov, N.; Noureddini, S. C.; Curiel, D. T.; Santegoets, S. J.; Scheper, R. J.; de Gruijl, T. D. A Single-Component Cd40-Targeted Adenovirus Vector Displays Highly Efficient Transduction and Activation of Dendritic Cells in a Human Skin Substrate System. Mol. Pharm. 2005, 2, 218-23.