Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib [9]

Leukemia

Volumn 19, Issue 10, 2005, Pages 1851-1853

  Hamzah, H G ^a   Pierce, A ^a   Stewart, W A ^b   Downes, Peter C ^c   Gray, A ^c   Irvine, A ^d   Spooncer, E ^a   Whetton, A D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d BELFAST CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BCR ABL PROTEIN; CD34 ANTIGEN; CHEMOTACTIC FACTOR; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; GROWTH FACTOR; IMATINIB; INTERLEUKIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE;

ANTINEOPLASTIC ACTIVITY; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; CYTOKINE PRODUCTION; DRUG PROTEIN BINDING; DRUG TARGETING; HEMATOPOIETIC STEM CELL; HUMAN; LETTER; LEUKEMIA CELL LINE; LEUKEMIA REMISSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 27144454373     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2403919     Document Type: Letter

References (6)

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5. Holyoake TL, Jiang X, Jorgensen HG, Graham S, Alcorn MJ, Laird C et al. Primitive quiescent leukaemic cells from patients with chronic myeloid leukaemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3. Blood 2001; 97: 720-728.
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