Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 2, 2005, Pages 912-920

  Notenboom, Sylvia ^a,c   Miller, David S ^b,c   Kuik, Leon H ^a,c   Smits, Paul ^a   Russel, Frans G M ^a   Masereeuw, Rosalinde ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c MOUNT DESERT ISLAND BIOLOGICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; FLUORESCEIN; GENTAMICIN; GUANYLATE CYCLASE; METHOTREXATE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 2; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CYCLIC GMP; DRUG RESISTANCE; ENZYME INHIBITORS; FUNDULIDAE; GENTAMICINS; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN SYNTHESIS INHIBITORS; RECEPTORS, ENDOTHELIN; SIGNAL TRANSDUCTION;

EID: 27144448793     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.089094     Document Type: Article

References (40)

1. Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, and Bonventre JV (2003) Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int 64:1189-1198.
2. Bauer B, Hartz AM, Fricker G, and Miller DS (2004) Pregnane X receptor upregulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol 66:413-419.
3. Bennett WM (1989) Mechanisms of aminoglycoside nephrotoxicity. Clin Exp Pharmacol Physiol 16:1-6.
4. Beuers U, Bilzer M, Chittattu A, Kullak-Ublick GA, Keppler D, Paumgartner G, and Dombrowski F (2001) Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33:1206-1216.
5. Bhalla US, Ram PT, and Iyengar R (2002) MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science (Wash DC) 297:1018-1023.
6. Forster RP and Taggart JV (1950) Use of isolated renal tubules in the estimation of metabolic processes associated with active cellular transport. J Cell Comp Physiol 36:251-270.
7. Foster JE, Harpur ES, and Garland HO (1992) An investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat. J Pharmacol Exp Ther 261:38-43.
8. Hegedus T, Sessler T, Scott R, Thelin W, Bakos E, Varadi A, Szabo K, Homolya L, Milgram SL, and Sarkadi B (2003) C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem Biophys Res Commun 302:454-461.
9. Ingolia NT and Murray AW (2002) Signal transduction: history matters. Science (Wash DC) 297:948-949.
10. Jaeschke H (2003) Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol 284:G15-G26.
11. Juhaszova M, Zorov DB, Kim SH, Pepe S, Fu Q, Fishbein KW, Ziman BD, Wang S, Ytrehus K, Antos CL, et al. (2004) Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Investig 113:1535-1549.
12. Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, and Edwards PA (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor and constitutive androstane receptor. J Biol Chem 277:2908-2915.
13. Korashy HM, Elbekai RH, and El Kadi AO (2004) Effects of renal diseases on the regulation and expression of renal and hepatic drug-metabolizing enzymes: a review. Xenobiotica 34:1-29.
14. Kubitz R, Huth C, Schmitt M, Horbach A, Kullak-Ublick G, and Haussinger D (2001) Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells. Hepatology 34:340-350.
15. Kullak-Ublick GA and Becker MB (2003) Regulation of drug and bile salt transporters in liver and intestine. Drug Metab Rev 35:305-317.
16. Laouari D, Yang R, Veau C, Blanke I, and Friedlander G (2001) Two apical multidrug transporters, P-gp and MRP2, are differently altered in chronic renal failure. Am J Physiol 280:F636-F645.
17. Maglich JM, Caravella JA, Lambert MH, Willson TM, Moore JT, and Ramamurthy L (2003) The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Nucleic Acids Res 31:4051-4058.
18. Masereeuw R, Russel FGM, and Miller DS (1996) Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy. Am J Physiol 271:F1173-F1182.
19. Masereeuw R, Terlouw SA, Van Aubel RA, Russel FG, and Miller DS (2000) Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule. Mol Pharmacol 57:59-67.
20. Miller DS, Letcher S, and Barnes DM (1996) Fluorescence imaging study of organic anion transport from renal proximal tubule cell to lumen. Am J Physiol 271:F508-F520.
21. Miller DS and Pritchard JB (1991) Indirect coupling of organic anion secretion to sodium in teleost (Paralichthys lethostigma) renal tubules. Am J Physiol 261:R1470-R1477.
22. Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, and Moore JT (2002) Pregnane X receptor (PXR), constitutive androstane receptor (CAR) and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Mol Endocrinol 16:977-986.
23. Notenboom S, Miller DS, Smits P, Russel FGM, and Masereeuw R (2002) Role of NO in endothelin-regulated drug transport in the renal proximal tubule. Am J Physiol 282:F458-F464.
24. Notenboom S, Miller DS, Smits P, Russel FGM, and Masereeuw R (2004) Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule. Am J Physiol 287:F33-F38.
25. Park KM, Byun JY, Kramers C, Kim JI, Huang PL, and Bonventre JV (2003) Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney. J Biol Chem 278:27256-27266.
26. Pendergrass W, Wolf N, and Poot M (2004) Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues. Cytometry 61:162-169.
27. Pritchard JB and Miller DS (1991) Comparative insights into the mechanisms of renal organic anion and cation secretion. Am J Physiol 261:R1329-R1340.
28. Renfro JL, Maren TH, Zeien C, and Swenson ER (1999) Renal sulfate secretion is carbonic anhydrase dependent in a marine teleost, Pleuronectes americanus. Am J Physiol 276:F288-F294.
29. Roelofsen H, Soroka CJ, Keppler D, and Boyer JL (1998) Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci 111:1137-1145.
30. Rushmore TH and Kong AN (2002) Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab 3:481-490.
31. Russel FGM, Masereeuw R, and Van Aubel RAMH (2002) Molecular aspects of renal anionic drug transport. Annu Rev Physiol 64:563-594.
32. Schaub TP, Kartenbeck J, Konig J, Spring H, Dorsam J, Staehler G, Storkel S, Thon WF, and Keppler D (1999) Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. J Am Soc Nephrol 10:1159-1169.
33. Schaub TP, Kartenbeck J, Konig J, Vogel O, Witzgall R, Kriz W, and Keppler D (1997) Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J Am Soc Nephrol 8:1213-1221.
34. Schinkel AH and Jonker JW (2003) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 55:3-29.
35. Schramm U, Fricker G, Wenger R, and Miller DS (1995) P-glycoprotein- mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules. Am J Physiol 268:F46-F52.
36. Terlouw SA, Graeff C, Smeets PHE, Fricker G, Russel FGM, Masereeuw R, and Miller DS (2002) Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule. J Pharmacol Exp Ther 301:578-585.
37. Terlouw SA, Masereeuw R, and Russel FGM (2003) Modulatory effects of hormones, drugs and toxic events on renal organic anion transport. Biochem Pharmacol 65:1393-1405.
38. Terlouw SA, Masereeuw R, Russel FGM, and Miller DS (2001) Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux. Mol Pharmacol 59:1433-1440.
39. Van Aubel RAMH, Smeets PHE, Peters JGP, Bindels RJM, and Russel FGM (2002) The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol 13:595-603.
40. Van Aubel RAMH, van Kuijck MA, Koenderink JB, Deen PMT, van Os CH, and Russel FGM (1998) Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. Mol Pharmacol 53:1062-1067.