Evaluation of viral replication in children with chronic hepatitis B with and without interferon treatment

Romanian Journal of Gastroenterology

Volumn 14, Issue 3, 2005, Pages 219-224

  Lazǎr, Cǎlin ^a,d   Grigorescu Sido, Paula ^a   Manasia, Rodica ^a   Mireştean, Ştefan ^a   Skorka, Cristina ^a   Neculoiu, Daniela ^b   Molnar, Geza ^c   Cocean, Stela ^c  

^a Axente Iancu 1st Pediatric Clinic   (Romania)

^b IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c Professor Iuliu Moldovan Institute of Public Health Cluj Napoca   (Romania)

^d 1st Pediatric Clinic   (Romania)

Author keywords

Children; Chronic hepatitis B; HBV DNA; Seroconversion

Indexed keywords

ALPHA INTERFERON; AMINOTRANSFERASE; HEPATITIS B ANTIBODY; HEPATITIS B ANTIGEN; VIRUS DNA;

ADOLESCENT; ARTICLE; CHEMICAL ANALYSIS; CHILD; CHRONIC HEPATITIS; CLINICAL EXAMINATION; CONTROLLED STUDY; DNA HYBRIDIZATION; FEMALE; HEPATITIS B; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; SEROCONVERSION; SEROLOGY; VIRUS REPLICATION;

EID: 27144448435     PISSN: 12214167     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Molnar GB, Popa S, Jebeleanu L, Damian C. A prevalence study of serum markers in hepatitis virus infection in the epidemiological anamnesis of the population. Bacteriol Virusol Parazitol Epidemiol 1994; 39: 141-150.
2. Grigorescu M, Pascu O, Strǎin R et al. Hepatitele cronice virale - recomandǎri terapeutice. Rom J Gatroenterol 1999; 8: 295-300.
3. de Franchis, Hadengne A, Lau G et al. EASL International Consensus Conference on Hepatitis B, 13-14 September 2002 Geneva, Consensus Statement. J Hepatol 2003; 39: S3-S25
4. Lok ASF, McMahon J. AASLD Practic Guidelines: Chronic Hepatitis B. Hepatology 2001; 34: 1225-1241.
5. Grigorescu-Sido P, Lazǎr C, Manasia R et al. Results of interferon treatment in children with chronic hepatitis B. Rom J Gastroenterol 2002; 11: 285-290.
6. Lazǎr C, Grigorescu-Sido P, Manasia R et al. Evaluarea replicǎrii virale prin determinarea Ag/AcHBe şi a ADN-VHB în hepatita cronicǎ viralǎ B la copil. Clujul Medical 2003; 2: 289-297.
7. Yuce A, Kocak N, Ozen H, Gurakan F. Prolonged interferon alpha treatment in children with chronic hepatitis B. Ann Trop Paediatr 2001; 21: 77-80
8. Barbera C, Bortolotti F, Crivellaro C et al. Recombinant interferon alpha 2a hastens the rate of HBe Ag clearance in children with chronic hepatitis B. Hepatology 1994; 20: 287-290.
9. Gurakan F, Kocak N, Ozen H, Yuce A. Comparison of standard and high dosage recombinant interferon alpha 2b for treatment of children with chronic hepatitis B infection. Pediatr Infect Dis J 2000; 19: 52-56.
10. Sokal EM, Wirth S, Goyens P et al. Interferon-alpha 2b therapy in children with chronic hepatitis B. Gut 1993; 34(2 suppl.): S87-S90.
11. Vajro P, Tedesco M, Fontanella A et al. Prolonged and high dose recombinant interferon alpha-2b alone or after prednisone priming accelerates termination of active viral replication in children with chronic hepatitis B infection. Pediatr Infect Dis J 1996; 15: 223-231.
12. Burguera M, Amat L, Garcia O et al. Treatment of chronic hepatitis B in children with recombinant alpha interferon. Different response according to age at infection. J Clin Gastroenterol 1993; 17: 296-299.
13. Narkewicz MR, Smith D, Silverman A et al. Clearance of chronic hepatitis B virus infection in young children after alpha interferon treatment. J Pediatr 1995; 127: 815-818.
14. Cullu F, Tumay CT, Kutlu T et al. Treatment of chronic viral hepatitis B in children with moderate doses of alpha interferon. Gastroenterol Clin Biol 1995; 19: 53-57.
15. Dikici B., Bosnak M, Bosnak V, et al. Comparison of treatments of chronic hepatitis B in children with lamivudine and alpha-interferon combination and alpha-interferon alone. Pediatr Int 2002; 44: 517-521.
16. Hwang SJ, Lu RH, Wang YJ et al. Clinical significance of changes in serum hepatitis B virus DNA titer in patients with chronic hepatitis B treated with interferon. Zhonghua Yi Xue Za Zhi 2000; 63: 1-7.
17. Castaneda Gouillot C, Escobar Capote HD, Garcia Bacallao O et al. Long term study with recombinant alfa 2b interferon in chronic active hepatitis due to B virus in children and adolescents. G.E.N. 1994; 48: 219-225.
18. Miu N, Burac L, Gheban D et al. Evaluation of interferon and hepatitis B vaccine-therapy in chronic hepatitis B in children. Rom J Gastroenterol 1999; 8: 3-7.
19. Moraru E, Goţia S, Coman G et al. Probleme practice ale tratamentului cu interferon alfa în hepatita cronicǎ activǎ postviralǎ la copii. Rev Rom Pediatr 1977; 3: 352-356.
20. Bortolotti F, Jara P, Barbera C et al. Long term effect of α- IFN in children with chronic hepatitis B. Gut 2000; 46: 715-718.
21. Chang MH, Hsu HY, Hsu HC et al. The significance of spontaneous hepatitis B e antigen seroconversion in childhood: with special emphasis on the clearance of hepatitis B e antigen before 3 years of age. Hepatology 1995; 22: 1387-1392.
22. Stajic M, Dojcinov D, Golubovic G, Milanovic B. Therapy of chronic hepatitis B with recombinant alpha-2 interferon (Roferon A-Roche). Rom J Gastroenterol 1994; 3: 9-12.
23. Martin P, Hann HW, Westerberg S et al. Interferon-alpha-2b therapy is efficacious in Asian-Americans with chronic hepatitis B infection: a prospective controlled trial. Dig Dis Sci 1998; 43: 875-879.
24. Martin-Vivaldi R, Nogueras F, Vignote ML et al. Multicenter retrospective study of response to interferon in chronic hepatitis B. Rev Esp Enferm Dig 2000; 92: 561-572.
25. Hsu HY, Chang MH, Lee CY et al. Spontaneous loss af HBs Ag in children with chronic hepatitis B virus infection. Hepatology 1992; 15: 382-386.
26. Ossama AS, Serebour FE, Skakni L. Hepatitis B surface gene mutants and their emerging role in the efficacy of HBV vaccinations programs. Hepatology 1999; 19: 74-79.
27. Fijisawa T, Inui A, Komatsu H et al. Hepatitis B precore mutant in children with chronic HBV infection. Pediatr Int 1999; 41: 603-608.
28. El-Zayadi A, Sober M. High frequency of the HbeAg-minus chronic HbsAg positive liver disease in Egypt. Int Hepatol Comm 1995; 3: 178-183.
29. Alagiozian-Angelova V, Alagiozian D, Antonov K et al. Clinical significance of serum HbeAg and HBV-DNA specific values of virus replication in chronic HBV infection. Folia Med 1998; 40: 34-41.
30. Bozdayi AM, Bozkaya H, Turkyilmaz A et al. Polymorphism of precore region of HBV DNA among patients with chronic HBV infection in Turkey. Infection 1999; 27: 357-360.
31. Mendy ME, Fortuin M, Hall AJ et al. HBV DNA in relation to duration of HBs antigen carriage. Br J Biomed Sci 1999; 56: 34-38.
32. Kessler HH, Preininger S, Stelzl E et al. Identification of different states of HBV infection with a quantitative PCR assay. Clin Diagn Lab Immunol 2000; 7: 298-300.
33. Chu CJ et al. Quantitative serum HBV-DNA levels during different stages of chronic hepatitis B infection. Hepatology 2002; 36: 1408-1415.
34. Mommeja-Marin H, Mondori E et al. Serum HBV-DNA as a marker of efficacy during therapy for chronic HBV infection: analysis and review of the literature. Hepatology 2003, 37: 135-140.
35. Hadziyannis SJ, Vassilopoulos D. Hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2001; 34: 617-624.
36. Braun J, Chieffe R, Chung R et al. Chronic HBV infection: a clinical care algorithm. The PRN Notebook 2004; 9: 25-28.
37. Yuen MF, Ng IO, Fan ST et al. Significance of HBV DNA levels in liver histology of HbeAg and Anti-HBe positive patients with chronic hepatitis B. Am J Gastroenterol 2004; 99: 2032-2037.
38. Rodrigues C, Deshmukh M, Jacob T et al. Significance of HBV-DNA by PCR over serological markers of HBV in acute and chronic patients. Ind J Gastroentero. 2001; 19: 141-144.
39. Gali MH. Management of the patient with hepatitis. Lifelong Learning Programs Practi-Med Dubai and Harvard Medical International, 2003.
40. Evans AA, O'Connell AP et al. Natural history of HBV infection. Fox Chase Cancer 2002 Scientific Report.