Polymorphism of precore region of hepatitis B virus DNA among patients with chronic HBV infection in Turkey

Infection

Volumn 27, Issue 6, 1999, Pages 357-360

  Bozdayi, A M ^a   Bozkaya, H ^a   Turkyilmaz A ^a   Aslan, N ^a   Verdi, H ^a   Kence, A ^b   Uzunalimoglu, O ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Epidemiology; Hepatitis; Nucleotide; Phenotype; Sequencing; Virology

Indexed keywords

ADENINE; CORE PROTEIN; GUANINE; HEPATITIS B(E) ANTIGEN; NUCLEOTIDE; THYMINE; VIRUS DNA;

ADULT; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; DEVICE; DNA POLYMORPHISM; DNA SEQUENCE; FAR EAST; FEMALE; GEOGRAPHIC DISTRIBUTION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; PREVALENCE; PROMOTER REGION; SOUTHERN EUROPE; STOP CODON; TURKEY (REPUBLIC);

ADOLESCENT; ADULT; AGED; BASE SEQUENCE; CHILD; DNA, VIRAL; FEMALE; HEPATITIS B ANTIBODIES; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; TURKEY; VARIATION (GENETICS);

EID: 0032758291     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/s150100050043     Document Type: Article

References (30)

1. Bruss V, Gerlich WH: Formation of transmembrane hepatitis B virus e antigen by cotranslational in vitro processing of the viral precore protein. Virology 1988; 163: 268-275.
2. Ou JH, Laub O, Rutter WJ: The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc Natl Acad Sci USA 1986; 83: 1578-1582.
3. Carman WF, Hadziyannis S, McGarvey MJ, Jacyna MR, Karayiannis P, Makris A, Thomas HC: Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989; 2: 588-590.
4. Brunetto MR, Stemler M, Schodel F, Will H, Ottobrelli A, Rizetto M, Verme G, Bonino F: Identification of HBV variants which cannot produce precore derived HBeAg and may be responsible for severe hepatitis. Ital J Gastroenterol 1989; 21: 151-154.
5. Bozkaya H, Ayola B, Lok ASF: High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. Hepatology 1996; 23: 32-36.
6. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi, M: Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 1990; 64: 1298-1303.
7. Hamasaki K, Nakata K, Nagatyama Y, Othusuru A, Daikoku M, Taniguchi K, Tsutsumi T, Sato Y, Kato Y, Nagataki S: Changes in the prevalence of HBeAg-negative mutant hepatitis B virus during the course of chronic hepatitis B. Hepatology 1994; 20: 8-14.
8. Lok ASF, Akarca U, Greene S: Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance. Hepatology 1995; 21: 19-24.
9. Chen IH, Huang CJ, Tong LP: Overlapping initiator and TATA box functions in the basal core promoter of hepatitis B virus. J Virol 1995; 69: 3647-3657.
10. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid-guanidium thiocyanate-phenol chloroform extraction. Anal Biochem 1987; 162: 156-159.
11. Harrison TJ, Hopes EA, Oon CJ, Zanetti AR, Zuckerman AJ: Independent emergence of a vaccine-induced escape mutant of hepatitis B virus. J Hepatol 1991; 13: 105-107.
12. Kwok S, Higuchi R: Avoiding false positives with PCR. Nature 1989; 339: 237-238.
13. Santantonio T, Jung MC, Miska S, Pastore G, Pape GR, Will H: High prevalence and heterogeneity of HBV preC mutants in anti-HBe-positive carriers with chronic liver disease in Southern Italy. J Hepatol 1991; 13: 78-81.
14. Brunetto MR, Giarin M, Sarracco G, Oliveri F, Calvo P, Capra G, Randone A, Abate ML, Manzini P, Capalbo M, Piantino P, Verme G, Bonino F: Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B. Gastroenterology 1993; 105: 845-850.
15. Pollicino T, Campo S, Raimondo G: Pre-S and core gene heterogeneity in hepatitis B virus (HBV) genomes isolated from patients with long-lasting HBV chronic infection. Virology 1995; 208: 672-677.
16. Benjelloun S, Tong S, Li J, Menfalout L, Trepo C, Benslimane A: Pre-core mutation associated with lack of hepatitis B e antigenemia in Moroccan asymptomatic carriers of the virus. Res Virol 1993; 144: 159-167.
17. Carman WF, Ferrao M, Lok ASF, Ma OCK, Lai CL, Thomas HC: Precore sequence variation in Chinese isolates of hepatitis B virus: relationship to HBe status and activity of liver disease. J Infect Dis 1992; 165: 127-133.
18. Naumov NV, Schneider R, Grötzinger T, Jung MC, Miska S, Pape GR, Will H: Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 1992; 102: 538-543.
19. Chuang WL, Omata M, Ehata T, Yokosuka O, Ito Y, Imazeki F, Lu SN, Chang WY, Ohto M: Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 1993; 104: 263-271.
20. Okamoto H, Tsuda F, Sakugawa H, Satrosoeswignjo RI, Imai M, Miyakawa Y, Mayumi M: Typing hepatitis B virus by homology in nucleoticle sequence: comparison of surface antigen subtypes. J Gen Virol 1988; 69: 575-583.
21. Norder H, Courece AM, Magnius LO: Complete genomes, phylogenetic relatedness, and structural proteins of six strains of hepatitis B virus, four of which represent two new genotypes. Virology 1994; 198: 499-503.
22. Li JS, Tong SP, Wen YM, Vitvitski L, Zhang Q, Trepo C: Hepatitis B virus genotype A rarely circulates as an Hbe-minus mutant: possible contribution of a single nucleotide in the precore region. J Virol 1993; 12: 5402-5410.
23. Rogriguez-Frias F, Buti M, Jardi R, Cotrina M, Viladomiu L, Esteban R, Guardia J: Hepatitis B virus infection: precore mutants and their relation to viral genotypes and core mutations. Hepatology 1995; 22: 1641-1647.
24. Lok ASF, Akarca U, Greene S: Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pregenome encapsidation signal. Proc Natl Acad Sci USA 1994; 91: 4077-4081.
25. Akahane Y, Yamanaka T, Suzuki H, Sugai Y, Tsuda F, Yotsumoto S, Omi S, Okamoto H, Miyakawa Y, Mayumi M: Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the pre-core region. Gastroenterology 1990; 99: 1113-1119.
26. Akarca US, Greene S, Lok ASF: Detection of pre-core hepatitis B virus mutants in asymptomatic hepatitis B surface antigen positive family members. Hepatology 1994; 19: 1366-1370.
27. Foster GR, Thomas HC: Recent advances in the molecular biology of hepatitis B virus: mutant virus and the host response. Gut 1993; 34: 1-3.
28. Sato S, Suzuki KK, Akahane Y, Akamatsu K, Akiyama K, Yunomura K, Tsuda F, Tanaka T, Okamato H, Miyakawa Y, Mayumi M: Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 1995; 122: 241-248.
29. Okamoto H, Tsuda F, Akahane Y, Sugal Y, Yoshiba M, Moriyama K, Tanaka T, Miyakawa Y, Mayumi, M: Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 1994; 68: 8102-8110.
30. Laskus T, Rakela J, Nowicki MJ, Persing DH: Hepatitis B virus core promoter sequence analysis in fulminant and chronic hepatitis B. Gastroenterology 1995; 109: 1618-1623.