Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 2, 2005, Pages 553-562

  Salter Cid, Luisa M ^a   Wang, Eric ^a   O'Rourke, Anne M ^a   Miller, Andrew ^a   Gao, Hongfeng ^a   Huang, Li ^a   Garcia, Arnie ^a   Linnik, Matthew D ^a  

^a La Jolla Pharmaceutical Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); ANTIINFLAMMATORY AGENT; CARRAGEENAN; CLORGYLINE; CYTOKINE; ENZYME INHIBITOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LJP 1207; N' (2 PHENYLALLYL)HYDRAZINE; PARGYLINE; SEMICARBAZIDE; UNCLASSIFIED DRUG; VASCULAR ADHESION PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; COLON; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; ENZYME INHIBITION; FEMALE; FOOT PAD; HISTOPATHOLOGY; MALE; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PAW EDEMA; PRIORITY JOURNAL; PROTEIN CONTENT; QUANTITATIVE ANALYSIS; RAT; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; SURVIVAL TIME; ULCERATIVE COLITIS;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL ADHESION; CLONING, MOLECULAR; COLITIS; CYCLOOXYGENASE 2; CYTOKINES; EDEMA; ENDOTHELIAL CELLS; ENDOTOXEMIA; FEMALE; HYDRAZINES; INFLAMMATION; MALE; MICE; MICE, INBRED STRAINS; MONOAMINE OXIDASE INHIBITORS; OXAZOLONE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 27144434590     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.089649     Document Type: Article

References (38)

1. Ager A (1987) Isolation and culture of high endothelial cells from rat lymph nodes. J Cell Sci 87:133-144.
2. Boirivant M, Fuss IJ, Chu A, and Strober W (1998) Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 188:1929-1939.
3. Buffoni F and Ignesti G (2000) The copper-containing amine oxidases: biochemical aspects and functional role. Mol Genet Metab 71:559-564.
4. Coughlan AF, Hau H, Dunlop LC, Berndt MC, and Hancock WW (1994) P-selectin and platelet-activating factor mediate initial endotoxin-induced neutropenia. J Exp Med 179:329-334.
5. Conklin DJ, Cowley HR, Wiechmann RJ, Johnson GH, Trent MB, and Boor PJ (2004) Vasoactive effects of methylamine in isolated human blood vessels: role of semicarbazide-sensitive amine oxidase, formaldehyde and hydrogen peroxide. Am J Physiol 286:H667-H676.
6. Fink MP (1995) Another negative clinical trial of a new agent for the treatment of sepsis: rethinking the process of developing adjuvant treatments for serious infections. Crit Care Med 23:989-991.
7. Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, and Strober W (2002) Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17:629-638.
8. Holt A, Alton G, Scaman CH, Loppnow GR, Szpacenko, Svendsen I, and Palcic MM (1998) Identification of the quinone cofactor in mammalian semicarbazide-sensitive amine oxidase. Biochemistry 37:4946-4957.
9. Holt A, Sharman DF, Baker GB, and Palcic MM (1997) A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates. Anal Biochem 244:384-392.
10. Ivanov AI, Pero RS, Scheck AC, and Romanovsky AA (2002) Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation. Am J Physiol 283:R1104-R1117.
11. Jaakkola K, Nikula T, Holopainen R, Vahasilta T, Matikainen MT, Laukkanen ML, Huupponen R, Halkola L, Nieminen L, Hiltunen J, et al. (2000) In vivo detection of vascular adhesion protein-1 in experimental inflammation. Am J Pathol 157:463-471.
12. Jakobsson PJ, Thoren S, Morgenstern R, and Samuelsson B (1999) Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96:7220-7225.
13. Kojima F, Naraba H, Sasaki Y, Okamoto R, Koshino T, and Kawai S (2002) Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells. J Rheumatol 29:1836-1842.
14. Li R, Klinman JP, and Mathews FS (1998) Copper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 A resolution reveals the active conformation. Structure 6:293-307.
15. Lizcano JM, Tipton KF, and Unzeta M (1998) Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung. Biochem J 331:69-78.
16. Lyles GA (1996) Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidase: biochemical, pharmacological and toxicological aspects. Int J Biochem Cell Biol 28:259-274.
17. Martelius T, Salaspuro V, Salmi M, Krogerus L, Hockerstedt K, Jalkanen S, and Lautenschlager I (2004) Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection. Am J Pathol 165:1993-2001.
18. O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, and Tipton KF (2004) Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do. Neurotoxicology 25:303-315.
19. Portanova JP, Zhang Y, Anderson GD, Hauser SD, Masferrer JL, Seibert K, Gregory SA, and Isakson PC (1996) Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia and interleukin 6 production in vivo. J Exp Med 184:883-891.
20. Salmi M and Jalkanen S (2001) VAP-1: an adhesin and an enzyme. Trends Immunol 22:211-216.
21. Salmi M, Tohka S, and Jalkanen S (2000) Human vascular adhesion protein-1 (VAP-1) plays a critical role in lymphocyte-endothelial cell adhesion cascade under shear. Circ Res 86:1245-1251.
22. Salmi M, Yegutkin GG, Lehvonen R, Koskinen K, Salminen T, and Jalkanen S (2001) A cell surface amine oxidase directly controls lymphocyte migration. Immunity 14:265-276.
23. Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W, Lee L, and Isakson P (1994) Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 9:12013-12017.
24. Sharma L, Melis E, Hickey MJ, Clyne CD, Erlich J, Khachigian LM, Davenport P, Morand E, Carmeliet P, and Tipping PG (2004) The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia. Am J Pathol 165:331-340.
25. Smith DJ, Salmi M, Bono P, Hellman J, Leu T, and Jalkanen S (1998a) Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. J Exp Med 188:17-27.
26. Smith CJ, Zhang Y, Koboldt CM, Muhammad J, Zweifel BS, Shaffer A, Talley JJ, Masferrer JL, Seibert K, and Isakson PC (1998b) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci USA 95:13313-13318.
27. Spertini O, Luscinskas FW, Kansas GS, Munro JM, Griffin JD, Gimbrone MA Jr, and Tedder TF (1991) Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol 147:2565-2573.
28. Stolen CM, Madanat R, Marti L, Kari S, Yegutkin GG, Sariola H, Zorzano A, and Jalkanen S (2004b) Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications. FASEB J 18:702-704.
29. Stolen CM, Marttila-Ichihara F, Koskinen K, Yegutkin GG, Turja R, Bono P, Skurnik M, Hanninen A, Jalkanen S, and Salmi M (2005) Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo. Immunity 22:105-115.
30. Stolen CM, Yegutkin GG, Kurkijarvi R, Bono P, Alitalo K, and Jalkanen S (2004) Origins of serum semicarbazide-sensitive amine oxidase. Circ Res 95:50-57.
31. Strober W, Fuss IJ, and Blumberg RS (2002) The immunology of mucosal models of inflammation. Annu Rev Immunol 20:495-549.
32. Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, and Cerami A (1987) Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature (Lond) 330:662-664.
33. Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, et al. (2003) Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci USA 100:9044-9049.
34. Villa P and Ghezzi P (2004) Animal models of endotoxic shock. Methods Mol Med 98:199-206.
35. Wang H, Yang H, and Tracey KJ (2004) Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med 255:320-531.
36. Yegutkin GG, Salminen T, Koskinen K, Kurtis C, McPherson MJ, Jalkanen S, and Salmi M (2004) A peptide inhibitor of vascular adhesion protein-1 (VAP-1) blocks leukocyte-endothelium interactions under shear stress. Eur J Immunol 34:2276-2285.
37. Yu P (2001) Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementia. Med Hypotheses 57:175-179.
38. Zhang X and McIntire WS (1996) Cloning and sequencing of a copper-containing, topa quinone-containing monoamine oxidase from human placenta. Gene (Amst) 179:279-286.