Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: Implications for developmental neurotoxicity

Toxicological Sciences

Volumn 86, Issue 1, 2005, Pages 125-131

  Seegal, Richard F ^a,b   Brosch, Karl O ^a   Okoniewski, Richard J ^a  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Brain; Coplanar; Developmental neurotoxicity; Dopamine; Polychlorinated biphenyls; Uterotropic

Indexed keywords

2,2',4,4' TETRACHLOROBIPHENYL; 3,3',4,4' TETRACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; DOPAMINE; FULVESTRANT; HEXACHLOROBIPHENYL; POLYCHLORINATED BIPHENYL DERIVATIVE; DRUG DERIVATIVE; ESTRADIOL; POLYCHLORINATED BIPHENYL; TERATOGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; ENVIRONMENTAL EXPOSURE; ESTROGEN ACTIVITY; FEMALE; FRONTAL CORTEX; MALE; NEUROTOXICITY; NONHUMAN; RAT; UTERUS WEIGHT; ANIMAL; DRUG EFFECT; FRONTAL LOBE; METABOLISM; ORGAN SIZE; PREGNANCY; PRENATAL DEVELOPMENT; SPRAGUE DAWLEY RAT; UTERUS;

ANIMALIA; RATTUS NORVEGICUS;

ANIMALS; ESTRADIOL; FEMALE; FRONTAL LOBE; MATERNAL EXPOSURE; ORGAN SIZE; POLYCHLORINATED BIPHENYLS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TERATOGENS; UTERUS;

EID: 26944485895     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi174     Document Type: Article

References (40)

1. Agrawal, A. K., Tilson, H. A., and Bondy, S. C. (1981). 3,4,3′,4′-Tetrachlorobiphenyl given to mice prenatally produces long term decreases in striatal dopamine and receptor binding sites in the caudate nucleus. Toxicol. Lett. 7, 417-424.
2. Amin, S., Moore, R. W., Peterson, R. E., and Schantz, S. L. (2000). Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats. Neurotoxicol. Teratol. 22, 675-682.
3. Bachmann, S., Hellwig, J., Jackh, R., and Christian, M. S. (1998). Uterotrophic assay of two concentrations of migrates from each of 23 polystyrenes administered orally (by gavage) to immature female Wistar rats. Drug. Chem. Toxicol. 21, 1-30.
4. Bemis, J. C., and Seegal, R. F. (1999). Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environ. Health Perspect. 107, 879-885.
5. Bemis, J. C., and Seegal, R. F. (2000). Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells. Neurotoxicology 21, 1123-1134.
6. Bemis, J. C., and Seegal, R. F. (2004). PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicol. Sci. 80, 288-295.
7. Darvill, T., Lonky, E., Reihman, J., Stewart, P., and Pagano, J. (2000). Prenatal exposure to PCBs and infant performance on the Fagan Test of Infant Intelligence. Neurotoxicology 21, 1029-1038.
8. Di Paolo, T., Rouillard, C., and Bedard, P. (1985). 17β-Estradiol at a physiological dose acutely increases dopamine turnover in rat brain. Eur. J. Pharmacol. 117, 197-203.
9. Dukes, M., Miller, D., Wakeling, A. E., and Waterton, J. C. (1992). Antiuterotrophic effects of a pure antioestrogen, ICI 182,780: Magnetic resonance imaging of the uterus in ovariectomized monkeys. J. Endocrinol. 135, 239-247.
10. Erickson, M. D. (1997). Analytical Chemistry of PCBs. CRC Press, Boca Raton, FL.
11. Garner, C. E., Jefferson, W. N., Burka, L. T., Matthews, H. B., and Newbold, R. R. (1999). In vitro estrogenicity of the catechol metabolites of selected polychlorinated biphenyls. Toxicol. Appl. Pharmacol. 154, 188-197.
12. Goldey, E. S., Kehn, L. S., Lau, C., Rehnberg, G. L., and Crofton, K. M. (1995). Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol. Appl. Pharmacol. 135, 77-88.
13. Hany, J., Lilienthal, H., Roth-Harer, A., Ostendorp, G., Birger, H., and Winneke, G. (1999). Behavioral effects following single and combined maternal exposure to PCB 77 (3,4,3′,4′-tetrachlorobiphenyl) and PCB 47 (2,4,2′4′-tetrachlorobiphenyl) in rats. Neurotoxicol. Teratol. 21, 147-156.
14. Huisman, M., Koopman-Esseboom, C., Fidler, V., Hadders-Algra, M., Van der Paauw, C. G., Tuinstra, L. G. M. T., Weisglas-Kuperus, N., Sauer, P. J. J., Touwen, B. C. L., and Boersma, E. R. (1995). Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development. Early Hum. Dev. 41, 111-127.
15. Jacobson, J. L., and Jacobson, S. W. (1996). Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N. Engl. J. Med. 335, 783-789.
16. Jansen, H. T., Cooke, P. S., Porcelli, J., Liu, T.-C., and Hansen, L. G. (1993). Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies. Reprod. Toxicol. 7, 237-248.
17. Kaya, H., Hany, J., Fastabend, A., Roth-Härer, A., Winneke, G., and Lilienthal, H. (2002). Effects of maternal exposure to a reconstituted mixture of polychlorinated biphenyls on sex-dependent behaviors and steroid hormone concentrations in rats: Dose-response relationship. Toxicol. Appl. Pharmacol. 178, 71-81.
18. Kester, M. H. A., Bulduk, S., Tibboel, D., Meinl, W., Glatt, H., Falany, C. N., Coughtrie, M. W. H., Bergman, A., Safe, S. H., Kuiper, G. G. J. M. et al. (2000). Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: A novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141, 1897-1900.
19. 3H]-phorbol ester binding in rat cerebellar granule cells by polychlorinated biphenyl mixtures and congeners: Structure-activity relationships. Toxicol. Appl. Pharmacol. 130, 140-148.
20. Koga, N., Beppu, M., and Yoshimura, H. (1990). Metabolism in vivo of 3,4,5,3′,4′-pentachlorobiphenyl and toxicological assessment of the metabolite in rats. J. Pharmacobio-Dyn. 13, 497-506.
21. Kohli, K. K., Gupta, B. N., Albro, P. W., Mukhtar, H., and McKinney, J. D. (1979). Biochemical effects of pure isomers of hexachlorobiphenyl: Fatty livers and cell structure. Chem. Biol. Interact. 25, 139-156.
22. Koopman-Esseboom, C., Morse, D. C., Weisglas-Kuperus, N., Lutkeschipholt, I. J., Van der Paauw, C. G., Tuinstra, L. G. M. T., Brouwer, A., and Sauer, P. J. J. (1994). Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr. Res. 36, 468-473.
23. Korach, K. S., Sarver, P., Chae, K., McLachlan, J. A., and McKinney, J. D. (1988). Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes. Mol. Pharmacol. 33, 120-126.
24. Layton, A. C., Sanseverino, J., Gregory, B. W., Easter, J. P., Sayler, G. S., and Schultz, W. (2002). In vitro estrogen receptor binding of PCBs: Measured activity and detection of hydroxylated metabolites in a recombinant yeast assay. Toxicol. Appl. Pharmacol. 180, 157-163.
25. Lind, P. M., Eriksen, E. F., Sahlin, L., Edlund, M., and Örberg, J. (1999). Effects of the antiestrogenic environmental pollutant 3,3′,4,4′,5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: Diverging effects in ovariectomized and intact animals. Toxicol. Appl. Pharmacol. 154, 236-244.
26. Mariussen, E., Andersen, J. M., and Fonnum, F. (1999). The effect of polychlorinated biphenyls on the uptake of dopamine and other neurotransmitters into rat brain synaptic vesicles. Toxicol. Appl. Pharmacol. 161, 274-282.
27. Morse, D. C., Groen, D., Veerman, M., van Amerongen, C. J., Koeter, H. B., Smits-Van Prooije, A. E., Visser, T. J., Koeman, J. H., and Brouwer, A. (1993). Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicol. Appl. Pharmacol. 122, 27-33.
28. Morse, D. C., Klasson-Welder, E., van de Pas, M., de Bie, A. Th. H. J., van Bladeren, P. J., and Brouwer, A. (1995). Metabolism and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl in pregnant and fetal rats. Chem. Biol. Interact. 95, 41-56.
29. Nesaretnam, K., Corcoran, D., Dils, R. R., and Darbre, P. (1996). 3,4,3′,4′-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo. Mol. Endocrinol. 10, 923-936.
30. Palkovits, M., and Brownstein, M. J. (1988). Maps and Guide to Microdissection of the Rat Brain. Elsevier, New York.
31. Pasqualini, C., Olivier, V., Guilbert, B., Frain, O., and Leviel, V. (1995). Acute stimulatory effect of estradiol on striatal dopamine synthesis. J. Neurochem. 65, 1651-1657.
32. Puymirat, J. (1985). Effects of dysthyroidism on central catecholaminergic neurons. Neurochem. Int. 7, 969-977.
33. Ramamoorthy, K., Gupta, M. S., Sun, G., McDougal, A., and Safe, S. H. (1999). 3,3′,4,4′-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis 20, 115-123.
34. Roegge, C. S., Seo, B. W., Crofton, K. M., and Schantz, S. L. (2000). Gestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats. Toxicol. Sci. 57, 121-130.
35. Seegal, R. F. (2001). Neurochemical effects of polychlorinated biphenyls: A selective review of the current state of knowledge. In PCBs: Recent Advances in Environmental Toxicology and Health Effects (L. W. Robertson, and L. G. Hansen, Eds.), pp. 241-255. The University Press of Kentucky, Lexington, KY.
36. Seegal, R. F. (2003). Effects of polychlorinated biphenyls on neuronal signaling. In Dioxins and Health (A. Schecter, and T. A. Gasiewicz, Eds.), pp. 433-455. John Wiley and Sons, Hoboken, NJ.
37. Seegal, R. F., Brosch, K. O., and Okoniewski, R. J. (1997). Effects of in utero and lactational exposure of the laboratory rat to 2,4,2′,4′- and 3,4,3′,4′-tetrachlorobiphenyl on dopamine function. Toxicol. Appl. Pharmacol. 146, 95-103.
38. Shain, W., Bush, B., and Seegal, R. F. (1991). Neurotoxicity of polychlorinated biphenyls: Structure-activity relationship of individual congeners. Toxicol. Appl. Pharmacol. 111, 33-42.
39. Winneke, G., Bucholski, A., Heinzow, B., Krämer, U., Schmidt, E., Walkowiak, J., Wiener, J.-A., and Steingrüber, H.-J. (1998). Developmental neurotoxicity of polychlorinated biphenyls (PCBS): Cognitive and psychomotor functions in 7-month old children. Toxicol. Lett. 102-103, 423-428.
40. Wong, P. W., Brackney, W. R., and Pessah, I. N. (1997). Ortho-substituted polychlorinated biphenyls alter microsomal calcium transport by direct interaction with ryanodine receptors of mammalian brain. J. Biol. Chem. 272, 15145-15153.