Tetramethylpyrazine inhibition on binding of radiolabeled ligand to VEGFR

Chinese Pharmacological Bulletin

Volumn 21, Issue 8, 2005, Pages 939-942

  Feng, Jun Dong ^a   Xu, Xiao Yu ^a   Hu, Yi Yong ^a   Chen, Gang ^a   Chen, Wei Hai ^a   Yang, Li Rong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Dissociation constant (Kd); Maximum binding capacity (Bmax); Radioligand binding assay (RBA); Reversed phase high performance liquid chromatography (RP HPLC); Serological pharmacology; Tetramethylpyrazine (TMP)

Indexed keywords

IODINE 125; PROTAMINE; TETRAMETHYLPYRAZINE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BLOOD LEVEL; DRUG EFFECT; LIGAND BINDING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 26944476305     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Giraudo E, Primo L, Audero E et al. Tumor necrosis factor-α regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells[J]. J Biol Chem, 1998, 273(34):22128-35.
2. Barleon B, Hauser S, Schöllman C et al. Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells[J]. J Cell Biochem, 1994, 54(1):56-63.
3. Ferrer FA, Miller LJ, Lindquist R et al. Expression of vascular endothelial growth factor receptors in human prostate cancer[J]. Urology, 1999, 54(3):567-72.
4. Langer I, Vertongen P, Perret J et al. Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in human neuroblastomas[J]. Med Pediatr Oncol, 2000, 34(6):386-93.
5. Bikfalvi AC, Sauzeau H, Meukadiri J et al. Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cell: Binding internalization, degradation, and biological effects[J]. J Cell Physiol, 1991, 149(1):50-9.
6. Walterberger JL, Claesson-Welsh A, Siegbahn M et al. Different signal transduction properties of KDR and flt-1, two receptors for vascular endothelial growth factor[J]. J Biol Chem, 1994, 269 (1):26988-95.
7. Brogi E, Schatteman G, Wu T et al. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. [J]. J Clin Invest, 1996, 97(2):469-76.
8. Millaner BS, Wizigmann-Voos H, Schnurch R et al. High affinity VEFG binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis[J]. Cell, 1993, 72(3):835-46.