Fusion of NUP214 to ABL1 on amplified episomes in T-ALL - Implications for treatment [6]

Leukemia

Volumn 19, Issue 9, 2005, Pages 1680-1681

  Stergianou, K ^a   Fox, C ^a   Russell, N H ^a  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; BCR ABL PROTEIN; IMATINIB; NUCLEAR PROTEIN; PROTEIN NUP214; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; NUCLEOPORIN; NUP214 PROTEIN, HUMAN; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; BONE MARROW TRANSPLANTATION; CANCER INFILTRATION; CANCER RELAPSE; CASE REPORT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE FUSION; HUMAN; INTERPHASE; KARYOTYPE; LETTER; MALE; METAPHASE; MOLECULAR PROBE; PRIORITY JOURNAL; T CELL LEUKEMIA; GENETICS; ONCOGENE; PLASMID; RECURRENT DISEASE;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ARTIFICIAL GENE FUSION; GENE AMPLIFICATION; GENES, ABL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, T-CELL, ACUTE; MALE; NUCLEAR PORE COMPLEX PROTEINS; PIPERAZINES; PLASMIDS; PYRIMIDINES; RECURRENCE;

EID: 26944431683     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2403877     Document Type: Letter

References (4)

1. Barber KE, Martineau M, Harewood L, Stewart M, Cameron E, Strefford JC et al. Amplification of the ABL gene in T-cell acute iymphoblastic leukaemia. Leukemia 2004; 18: 1153-1156.
2. Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R et al. Fusion of NUP214 to ABL1 on amplified episomes in T-acute lymphoblastic leukaemia. Nat Genet 2004; 36: 1084-1089.
3. Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293: 876-880.
4. Lee S, Kim YJ, Min CK, Kim HJ, Eom KS, Kim DW et al. The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukaemia. Blood 2005; 105: 3449-3457.