Pharmacological studies on mechanisms of aminophylline-induced seizures in rats

Indian Journal of Experimental Biology

Volumn 43, Issue 10, 2005, Pages 849-853

  Ray, Arunabha ^a   Gulati, Kavita ^a   Anand, Seema ^a   Vijayan, V K ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

Aminophylline; Antioxidant; Oxidative stress; Seizures

Indexed keywords

AMINOPHYLLINE; ANTICONVULSIVE AGENT; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; DIZOCILPINE MALEATE; ENZYME INHIBITOR; FREE RADICAL; OXIDIZING AGENT; PENTOXIFYLLINE; PHENYTOIN; PHOSPHODIESTERASE INHIBITOR; REACTIVE OXYGEN METABOLITE; ROLIPRAM; SCAVENGER; TRIENTINE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; MALE; OXIDATIVE STRESS; RAT; SEIZURE; WISTAR RAT;

AMINOPHYLLINE; ANIMALS; ANTICONVULSANTS; ANTIOXIDANTS; BUTHIONINE SULFOXIMINE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; FREE RADICALS; MALE; OXIDANTS; OXIDATIVE STRESS; PENTOXIFYLLINE; PHENYTOIN; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; ROLIPRAM; SEIZURES; TRIETHYLENETETRAMINE;

EID: 26844532807     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Barnes P J Theophylline . in Asthma : Basic mechanisms and clinical management, edited by Barnes P J, Rodger I W and Thomson N C, (Academic Press, San Diego, USA), 1998, 689.
2. Barnes P J & Pauwels R A, Theophylline in the management of asthma : Time for reappraisal, Eur Respir J, 7 (1995) 579
3. Nakada T, Kwee I L , Lerner A M & Remler M P, Theophylline induced seizures : Clinical and pathophysiological aspects, West J Med , 138 (1983) 371.
4. Hornfeldt C S & Larson A A, Adenosine receptors are not involved in theophylline-induced seizures, J Toxicol Clin Toxicol, 32 (1994) 257.
5. Chakrabarti A, Saini H K & Garg S K, Dose finding study with nimodipine : A selective central nervous system calcium channel blocker, on aminophylline induced seizure model in rats, Brain Res Bull, 45 (1998) 495.
6. Lohr J B & Browning J A, Free radical involvement in neuropsychiatric illnesses, Psychopharmacol Bull, 31 (1995) 159.
7. Wardle E N, Free radicals and lipid peroxidation in relation to pathophysiological mechanisms, Saudi Med J, 11 (1990) 181.
8. Frantseva M V, Perez Velazquez J L, Tsoraklidis G, Mendonca A J, Adamchik Y, Mills L R, Carlen P L & Burnham M W. Oxidative stress is involved in seizure induced neurodegeneration in the kindling model of epilepsy, Neuroscience, 97 (2000) 431.
9. Chu N S, Caffeine and aminophylline induced seizures, Epilepsia, 22 (1982) 85.
10. During M J & Spencer D D, Adenosine : A mediator of seizure arrest and post-ictal refractoriness, Ann Neurol, 32 (1992) 618.
11. Dragunow M, The brain's natural anticonvulsant, Trends Pharmacol Sci , 7 (1986) 128.
12. Torphy T J, Phosphodiesterase isoenzymes : Molecular targets for novel anti-asthma agents, Am J Res Crit Care Med, 157 (1998) 351.
13. Scmidt G, Dent G & Rabe K F, Selective phopsphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease, Clin Exp Allergy, 29 (1999) 99
14. Walker J E, Effect of aminophylline on seizure threshold and brain regional cyclic nucleotides in the rat, Exp Neurol , 74 (1981) 299.
15. Lebel C P & Bondy S C, Oxygen radicals : Common mediators of neurotoxicity, Neurotoxicol Teratol , 13 (1991) 341.
16. Cotgreave I A, Moldeus P & Orrenius S, Host biochemical defense mechanisms against pro oxidant, Annu Rev Pharmacol Toxicol, 28 (1988)189.
17. Lowe D J F, Watson I D, Williams J & Berry D J, The chemical use and measurement of theophylline, Ann Clin Biochem, 25 (1988) 4.
18. Yu B P, Cellular defense against damage from reactive oxygen species, Physiol Rev, 74 (1994) 139.
19. Reiter R J, Tan D X & Allegra M, Melatonin : Reducing molecular pathology and dysfunction due to free radicals and associated reactions, Neuroendocrinol Lett, 23 (2002) 3.
20. Simonian N A & Coyle J T, Oxidative stress in neurodegenerative diseases, Annu Rev Pharmacol Toxicol, 36 (1996) 83.
21. Meister A, Glutathione deficiency produced by inhibition of its synthesis and its reversal, application in research and therapy, Pharmac Therap, 51 (1991) 155.