When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity

Chemistry - A European Journal

Volumn 11, Issue 20, 2005, Pages 5866-5874

  Caravan, Peter ^a   Amedio Jr , John C ^a   Dunham, Stephen U ^a   Greenfield, Matthew T ^a   Cloutier, Normand J ^a   McDermid, Sarah A ^a   Spiller, Marga ^b   Zech, Stephan G ^a   Looby, Richard J ^a   Raitsimring, Arnold M ^c   McMurry, Thomas J ^a   Lauffer, Randall B ^a  

^a EPIX Pharmaceuticals   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c University of Arizona   (United States)

Author keywords

Gadolinium, imaging agents; Magnetic resonance imaging; Relaxivity; Serum albumin

Indexed keywords

HYDRATION; MAGNETIC RESONANCE IMAGING; MOLECULES; PROTONS;

BINDING GROUPS; COORDINATED WATER; WATER MOLECULES;

ORGANIC COMPOUNDS;

CONTRAST MEDIUM; GADOLINIUM PENTETATE; WATER;

ARTICLE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ULTRAFILTRATION;

CONTRAST MEDIA; GADOLINIUM DTPA; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; ULTRAFILTRATION; WATER;

EID: 26844444251     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200500338     Document Type: Article

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