Improved method for the synthesis of 2-methyl-2-aryloxypropanoic acid derivatives

Synthesis

Volumn , Issue 12, 2004, Pages 1959-1962

  Davis, Roman D ^a   Fitzgerald, Russ N ^a   Guo, Jiasheng ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

2 methyl 2 aryloxypropanoic acid; Alkylation; Fibric acid; PPAR agonist

Indexed keywords

DIABETES; TREATMENT;

DISEASES; ORGANIC COMPOUNDS; SYNTHESIS (CHEMICAL);

ORGANIC ACIDS;

2 (2 CHLOROPHENOXY) 2 METHYLPROPANOIC ACID; 2 (4 METHOXYPHENOXY) 2 METHYLPROPANOIC ACID; 2 (4 TRIFLUOROMETHYLPHENOXY) 2 METHYLPROPANOIC ACID; 2 [[4 [2 [[4 (3,4 DIFLUOROPHENYL) 1,3 THIAZOL 2 YL][[4 (TRIFLUOROMETHYL) PHENYL]METHYL]AMINO]ETHYL]PHENYL]OXY] 2 METHYLPROPANOIC ACID; CLOFIBRIC ACID; FENOFIBRIC ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; DRUG TRANSFORMATION; NON INSULIN DEPENDENT DIABETES MELLITUS;

EID: 4444337353     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-829171     Document Type: Article

References (20)

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10. We thank Prof. Barry Trost, Stanford University, for first suggesting this reagent to us.
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