Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3′-C- ethynylcytidine (ECYD)

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 397-400

  Hrdlicka, Patrick J ^a   Jepsen, Jan S ^b   Wengel, Jesper ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3' ETHYNYLCYTIDINE; 5 BROMOURACIL DERIVATIVE; 5 IODOURACIL DERIVATIVE; AZACITIDINE; AZAURIDINE; CYTIDINE DERIVATIVE; NUCLEIC ACID BASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; HUMAN; HUMAN CELL; IC 50;

ANTIMETABOLITES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CYTIDINE; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NEOPLASMS; NUCLEIC ACID CONFORMATION; URACIL; URIDINE;

EID: 26644462658     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200059821     Document Type: Conference Paper

References (9)

1. Hattori, H.; Tanaka, M.; Fukushima, M.; Sasaki, T.; Matsuda, A. J. Med. Chem. 1996, 39, 5005-5011.
2. Matsuda, A.; Sasaki, T. Cancer Sci. 2004, 95, 105-111.
3. Van Rompay, R.; Norda, A.; Linden, K.; Johansson, M.; Karlsson, A. Mol. Pharmacol. 2001, 59, 1181-1186.
4. Marquez, V.E.; Ezzitouni, A.; Russ, P.; Siddiqui, M.A.; Ford, H., Jr.; Feldman, R.J.; Mitsuya, H.; George, C.; Barchi, J.J., Jr. J. Am. Chem. Soc. 1998, 120, 2780-2789.
5. Obika, S.; Morio, K.; Nanbu, D.; Hari, Y.; Itoh, H.; Imanishi, T. Tetrahedron 2002, 58, 3039-3049.
6. Wengel, J. Act. Chem. Res. 1999, 32, 301-310.
7. Kakinuma, K.; Iihama, Y.; Takagi, I.; Ozawa, K.; Yamauchi, N.; Imamura, N.; Esumi, Y.; Uramoto, M. Tetrahedron 1992, 48, 3768-3774.
8. Tam, T.F.; Fraser-Reid, B. Can. J. Chem. 1979, 57, 2818-2822.
9. Procopiou, P.A.; Baugh, S.P.D.; Flack, S.S.; Inglis, G.G.A. J. Org. Chem. 1998, 63, 2342-2347.