A new approach to the synthesis of 4′-carbon-substituted nucleosides: Development of a highly active anti-HIV agent 2′, 3′-didehydro- 3′-deoxy-4′-ethynylthymidine

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 343-347

  Haraguchi, Kazuhiro ^a   Takeda, Shingo ^a   Sumino, Masanori ^a   Tanaka, Hiromichi ^a   Dutschman, Ginger E ^b   Cheng, Yung Chi ^b   Nitanda, Takao ^c   Baba, Masanori ^c  

^a SHOWA UNIVERSITY   (Japan)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

4 Substituted Nucleosides; Anti HIV; Didehydro 3 Deoxythymidine; Dimethyldioxirane; Epoxidation; Lewis Acids; Organoaluminum Reagents; Organosilicon Reagents

Indexed keywords

2',3' DIDEHYDRO 3' DEOXY 4' ETHYNYLTHYMIDINE; 4' ETHYNYLSTAVUDINE; ALUMINUM DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBON; DIMETHYLDIOXIRANE; EPOXIDE; NUCLEOSIDE DERIVATIVE; ORGANOSILICON DERIVATIVE; STAVUDINE; THYMIDINE; UNCLASSIFIED DRUG;

CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; CONFERENCE PAPER; DRUG POTENCY; DRUG SYNTHESIS; EPOXIDATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; NONHUMAN; REACTION OPTIMIZATION; STEREOCHEMISTRY; SUBSTITUTION REACTION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CARBON; CELL LINE; HIV; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NUCLEOSIDES; OXYGEN; STAVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 26644462419     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200059774     Document Type: Conference Paper

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