D-4′-thioadenosine derivatives as highly potent and selective agonists at the human A3 adenosine receptor

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 607-609

  Lee, Hyouk Woo ^a   Shin, Dae Hong ^b   Jeong, Ji Young ^b   Kim, Hea Ok ^c   Chun, Moon Woo ^a   Melman, N ^c   Gao, Z G ^c   Jacobson, Kenneth A ^c   Jeong, Lak Shin ^b  

^a Ewha Womans University   (South Korea)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N6 METHYLADENOSINE 5' METHYLURONAMIDE; 4' THIOADENOSINE DERIVATIVE; 4' THIONUCLEOSIDE DERIVATIVE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE DERIVATIVE; GAMMA LACTONE DERIVATIVE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; 2 CHLORO N(6) METHYLADENOSINE 5' METHYLURONAMIDE; 2-CHLORO-N(6)-METHYLADENOSINE-5'-METHYLURONAMIDE; 4'-THIOADENOSINE; ACETIC ACID DERIVATIVE; ADENOSINE; DRUG DERIVATIVE; FURAN DERIVATIVE; GLUCONIC ACID; LACTONE; LIGAND; NUCLEOSIDE; OXYGEN; THIOADENOSINE;

BINDING AFFINITY; CONFERENCE PAPER; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ANIMAL; ARTICLE; CHEMICAL MODEL; CHEMISTRY; DRUG POTENTIATION; HUMAN; KINETICS; PROTEIN BINDING; RAT;

ACETATES; ADENOSINE; ANIMALS; FURANS; GLUCONATES; HUMANS; KINETICS; LACTONES; LIGANDS; MODELS, CHEMICAL; NUCLEOSIDES; OXYGEN; PROTEIN BINDING; RATS; RECEPTOR, ADENOSINE A3; THIONUCLEOSIDES;

EID: 26644442812     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200061827     Document Type: Conference Paper

References (3)

1. 3-adenosine receptors. J. Med. Chem. 1994, 37, 3614-3621.
2. Jacobson, K.A.; Knutsen, LJ.S. P1 and P2 purine and pyrimidine receptors. In Purinergic and Pyrimidinergic Signalling I; Abbracchio, M.P., Williams, M., Eds.; Handbook of Experimental Pharmacology, Springer-Verlag: Berlin, Germany, 2001; Vol. 151/1, 129-175.
3. Jeong, L.S.; Yoo, S.J.; Lee, K.M.; Koo, M,.J.; Choi, W.J.; Kim, H.O.; Moon, H.R.; Lee, M.Y.; Park, J.G.; Lee, S.K.; Chun, M.W. Design, synthesis and biological evaluation of fluoro-neplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase. J. Med. Chem. 2003, 46(2), 201-203.