Interaction of porphyrin with G-quadruplex structures

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 753-756

  Erra, Eva ^a   Petraccone, Luigi ^b   Esposito, Veronica ^a   Randazzo, Antonio ^a   Mayol, Luciano ^a   Ladbury, John ^c   Barone, Guido ^a   Giancola, Concetta ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Drug DNA Interactions; G Quadruplex; Isothermal Titration Calorimetry; Porphyrin

Indexed keywords

PORPHYRIN;

BINDING AFFINITY; CHEMICAL STRUCTURE; CONFERENCE PAPER; DNA PROBE; DNA SEQUENCE; DRUG DNA INTERACTION; ISOTHERMAL TITRATION CALORIMETRY; STOICHIOMETRY; THERMODYNAMICS;

BIOPHYSICS; CALORIMETRY; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; LIGANDS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; PORPHYRINS; TEMPERATURE; THERMODYNAMICS; TIME FACTORS;

EID: 26644441931     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060070     Document Type: Conference Paper

References (4)

1. Hurley, L.H.; Wheelhouse, R.T.; Sun, D.; Kerwin, S.M.; Salazar, M.; Fedoroff, O.Y.; Han, F.X.; Han, H.; Izbicka, E.; Von Hoff, D.D. G-quadruplexes as targets for drug design. Pharmacol. Ther. 2000, 85, 141-158.
2. Haq, I. Thermodynamics of drug-DNA interactions. Arch. Biochem. Biophys. 2002, 403, 1-15.
3. Haq, I.; Ladbury, J. Drug DNA recognition: energetics and implications for design. J. Mol. Recognit. 2000, 13, 188-197.
4. Haq, I.; Trent, J.O.; Chowdhry, B.Z.; Jenkins, T.C. Intercalative G-tetraplex stabilization of telomeric DNA by a cationic porphyrin. J. Am. Chem. Soc. 1999, 121, 1768-1779.