Design and synthesis of specific inhibitors of the 3′-processing step of HIV-1 integrase

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 481-484

  Chi, Guochen ^a   Seo, Byung I ^a   Nair, Vasu ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Cyclic Dinucleotide; HIV 1 Integrase; Inhibitors

Indexed keywords

DINUCLEOTIDE; DINUCLEOTIDE 5' PHOSPHATE DERIVATIVE; INTEGRASE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; BINDING SITE; CONFERENCE PAPER; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; INHIBITION KINETICS; MOLECULAR MODEL; VIRUS MUTATION; WILD TYPE;

ANTI-HIV AGENTS; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NUCLEOTIDES; RECOMBINANT PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 26644436277     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060015     Document Type: Conference Paper

References (13)

1. Frankel, A.D.; Young, J.A.T. HIV-1: fifteen proteins and an RNA. Annu. Rev. Biochem. 1998, 67, 1-25.
2. Asante-Appiah, E.; Skalka, A.M. HIV-1 integrase: structural organization, conformational changes, and catalysis. Adv. Virus Res. 1999, 52, 351-369.
3. Esposito, D.; Craigie, R. HIV integrase structure and function. Adv. Virus Res. 1999, 52, 319-333.
4. Nair, V. HIV integrase as a target for antiviral chemotherapy. Rev. Med. Virol. 2002, 12, 179-193.
5. Engelman, A.; Mizuuchi, K.; Craigie, R. HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell 1991, 67, 1211-1221.
6. Mazumder, A.; Uchida, H.; Neamati, N.; Sunder, S.; Jaworska-Maslanka, M.; Wickstrom, E.; Zeng, F.; Jones, R.A.; Mandes, R.F.; Chenault, H.K.; Pommier, Y. Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides. Mol. Pharmacol. 1997, 51, 567-575.
7. Taktakishvili, M.; Neamati, N.; Pommier, Y.; Pal, S.; Nair, V. Recognition and inhibition of HIV integrase by novel dinucleotides. J. Am. Chem. Soc. 2000, 122, 5671-5677.
8. Hsu, C.-Y.; Dennis, D.; Jones, R.A. Synthesis and physical characterization of bis- 3′, 5′ cyclic dinucleotides (Np-Np): RNA polymerase inhibitors. Nucleosides Nucleotides 1985, 4, 377-389.
9. Barbato, S.; De Napoli, L.; Mayol, L.; Piccialli, G.; Santacroce, C. A polymer-nucleotide linkage useful for the solid-phase synthesis of cyclic oligodeoxyribonucleotides. Tetrahedron 1987, 45, 4523-4536.
10. Capobianco, M.L.; Carcuro, A.; Tondelli, L.; Garbesi, A.; Bonora, G.M. One pot solution synthesis of cyclic oligodeoxyribonucleotides. Nucleic Acids Res. 1990, 18, 2661-2669.
11. Zeng, F.; Jones, R.A. Synthesis of cyclic dinucleotides by an H-phosphonate method in solution. Nucleosides Nucleotides 1996, 15, 1679-1686.
12. Sproat, B.S.; Gait, M.J. Solid-phase Synthesis of Oligodeoxyribonucleotides by the Phosphotriester Method in Oligonucleotide Synthesis: A Practical Approach; Gait, M. J., Ed.; IRL Press: Oxford, 1984; 94-96.
13. Reese, C.B.; Titmas, R.C.; Yau, L. Oximate ion promoted unblocking of oligonucleotide phosphotriester intermediates. Tetrahedron Lett. 1978, 19, 2727-2730.