Structure-activity relationship of 5′-substituted fluoro-neplanocin A analogues as potent inhibitors of S-adenosylhomocysteine hydrolase

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 707-708

  Moon, Hyung Ryong ^a   Lee, Kang Man ^b   Lee, Hyun Joo ^b   Lee, Sang Kook ^b   Park, Seung Bin ^a   Chun, Moon Woo ^c   Jeong, Lak Shin ^b  

^a Pusan National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSYLHOMOCYSTEINASE INHIBITOR; NEPLANOCIN A;

CONFERENCE PAPER; CYTOTOXICITY; DRUG INHIBITION; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; ANTIVIRAL AGENTS; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 26644432957     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060286     Document Type: Conference Paper

References (4)

1. Hasobe, M.; McKee, J.G.; Borchardt, R.T. Relationship between intracellular concentration of S-adenosylhomocysteine and inhibition of vaccinia virus replication and inhibition of murine L-929 cell growth. Antimicrob. Agents Chemother. 1989, 33(6), 828-834.
2. Wolfe, M.S.; Borchardt, R.T. S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy. J. Med. Chem. 1991, 34(5), 1521-1530 and references therein.
3. Jeong, L.S.; Yoo, S.J.; Lee, K.M.; Koo, M.J.; Choi, W.J.; Kim, H.O.; Moon, H.R.; Lee, M.Y.; Park, J.G.; Lee, S.K.; Chun, M.W. Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase. J. Med. Chem. 2003, 46(2), 201-203.
4. Choi, W.J.; Moon, H.R.; Kim, H.O.; Yoo, B.N.; Lee, J.A.; Shin, D.H.; Jeong, L.S. Preparative and stereoselective synthesis of the versatile intermediate for carbocyclic nucleosides: effects of the bulky protecting groups to enforce facial selectivity. J. Org. Chem. 2004, 69(7), 2634-2636.