Lentiviral-mediated delivery of combined HIV-1 decoy TAR and Vif siRNA as a single RNA molecule that cleaves to inhibit HIV-1 in transduced cells

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 431-434

  Barnor, Jacob Samson ^a,b   Miyano Kurosaki, Naoko ^a   Yamaguchi, Kazuya ^a   Abumi, Yusuke ^a   Ishikawa, Koichi ^c   Yamamoto, Naoki ^c   Takaku, Hiroshi ^a,d  

^a CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

^b University of Ghana   (Ghana)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d High Technology Research Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; LENTIVIRUS VECTOR; MESSENGER RNA; RIBONUCLEASE III; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIF PROTEIN; VIRUS DECOY TAR PROTEIN; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BINDING COMPETITION; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INFECTION CONTROL; LONG TERMINAL REPEAT; PROMOTER REGION; PROTEIN INTERACTION; RNA DEGRADATION; RNA INTERFERENCE; SEQUENCE ANALYSIS; VIRAL GENE DELIVERY SYSTEM; VIRUS INHIBITION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-HIV AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, VIF; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; JURKAT CELLS; LENTIVIRUS; MODELS, GENETIC; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS;

HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS;

EID: 26644432531     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200059981     Document Type: Conference Paper

References (4)

1. Fire, A.; Xu, S.-Q.; Montgomery, M.K.; Kostas, S.A.; Driver, S.E.; Mello, C.C. Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans. Nature 1998, 391, 806-811.
2. Elbashir, S.M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Welber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture. Nature 2001, 411, 494-498.
3. Barnor, J.S.; Miyano-Kurosaki, N.; Yamaguchi, K.; Sakamoto, A.; Ishikawa, K.; Inagaki, Y.; Yamamoto, N.; Osei-Kwasi, M.; Ofori-Adjei, D.; Takaku, H. Intracellular expression of antisense RNA transcripts complementary to the human immunodeficiency virus type-1 Vif gene inhibits viral replication in infected T-lymphoblastoid cells. Biochem. Biophys. Res. Commun. 2004, 544-550.
4. Brummelkamp, T.R.; Bernards, R.; Agami, R.A. System for stable expression of short interfering RNAs in mammalian cells. Science 2002, 296, 550-553.