The efficacy of a 'master switch gene' HIF-1α in a porcine model of chronic myocardial ischaemia

European Heart Journal

Volumn 26, Issue 13, 2005, Pages 1327-1332

  Heinl Green, Amanda ^a   Radke, Peter W ^a   Munkonge, Felix M ^a   Frass, Oliver ^b   Zhu, Jie ^a   Vincent, Karen ^c   Geddes, Duncan M ^a   Alton, Eric W F W ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b Universitatsklinik   (Germany)

^c GENZYME CORPORATION   (United States)

Author keywords

Angiogenesis; Gene therapy; HIF 1 ; Myocardium

Indexed keywords

ADENOVIRUS VECTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLASMID DNA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; GENETIC CODE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; MALE; NONHUMAN; PARAMETER; PLASMID; PRIORITY JOURNAL; RANDOMIZATION; REOPERATION; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; STRESS; SWINE; THORACOTOMY; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CHRONIC DISEASE; CORONARY CIRCULATION; ECHOCARDIOGRAPHY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, SWITCH; GENETIC VECTORS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MODELS, BIOLOGICAL; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; RANDOM ALLOCATION; SWINE; TRANSCRIPTION FACTORS;

EID: 26444585064     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehi223     Document Type: Article

References (19)

1. Simons M. Therapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi? Am J Physiol Heart Circ Physiol 2001;280:H1923-H1927.
2. Henry TD, Annex BH, McKendall GR et al. The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation 2003;107:1359-1365.
3. Darland DC, D'Amore PA. Blood vessel maturation: vascular development comes of age. J Clin Invest 1999;103:157-158.
4. Asahara T, Bauters C, Zheng LP et al. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation 1995;92(Suppl. II):365-371.
5. Vincent KA, Shyu KG, Luo Y et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 2000;102:2255-2261.
6. Li J, Post M, Volk R et al. PR39, a peptide regulator of angiogenesis. Nat Med 2000;6:49-55.
7. The TIMI Research Group. Immediate vs delayed catheterization and angioplasty following thrombolytic therapy for acute myocardial infarction. TIMI II A results. JAMA 1988;260:2849-2858.
8. Rentrop KP, Cohen M, Blanke H et al. Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol 1985;5:587-592.
9. Armentano D, Sookdeo CC, Hehir KM et al. Characterization of an adenovirus gene transfer vector containing an E4 deletion. Hum Gene Ther 1995;10:1343-1353.
10. Aherne WA, Dunnill MS. Point counting and morphometry. In: Aherne WA, Dunnill MS, eds. Morphometery. London: Arnold E; 1982, p33-45.
11. Sabattini E, Bisgaard K, Ascani S et al. The EnVision++ system: a new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques. J Clin Pathol 1998;51:506-511.
12. Peterson GL. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 1977;83:346-356.
13. Schwarz ER, Speakman MT, Patterson M et al. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat-angiogenesis and angioma formation. J Am Coll Cardiol 2000; 35:1323-1330.
14. Shyu KG, Wang MT, Wang BW et al. Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat. Cardiovasc Res 2002;54:576-583.
15. Selke FW, Wang SY, Stamler A et al. Enhanced microvascular relaxation to VEGF and bFGF in chronically ischemic porcine myocardium. Am J Physiol 1996;271:H713-H720.
16. Sato K, Wu T, Laham RJ et al. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. J Am Coll Cardiol 2001;37:616-623.
17. Lopez JJ, Laham RJ, Carrozza JP et al. Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response. Am J Physiol 1997;273:H1317-H1323.
18. Horrigan MC, MacIsaac AI, Nicolini FA et al. Reduction in myocardial infarct size by basic fibroblast growth factor after temporary coronary occlusion in a canine model. Circulation 1996;94: 1927-1933.
19. Freedman SB, Vale P, Kalka C et al. Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA. Hum Gene Ther 2002;13:1595-1603.