메뉴 건너뛰기




Volumn , Issue 36, 2005, Pages 4575-4577

Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; IRON CHELATING AGENT; MEMBRANE PROTEIN; PHOSPHOLIPID; VIRUS PROTEIN;

EID: 26444552839     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b507917a     Document Type: Article
Times cited : (26)

References (26)
  • 7
    • 0029074762 scopus 로고
    • Only intramolecular cleavage reactions of integral membrane proteins, using Fe(III)-EDTA and Cu-phenanthroline complexes conjugated to cysteine thiols, have been reported. See, J. Wu, D. M. Perrin, D. S. Sigman and H. R. Kaback, Proc. Natl. Acad. Sci. USA, 1995, 92, 9186;
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9186
    • Wu, J.1    Perrin, D.M.2    Sigman, D.S.3    Kaback, H.R.4
  • 13
    • 0001484549 scopus 로고    scopus 로고
    • Artificial phospholipids possessing a photoactivatable group and a disulfide moiety have been prepared for the investigation of protein-lipid and lipid-lipid interactions, respectively. For example, see, G. D. Prestwich, Acc. Chem. Res., 1996, 29, 503;
    • (1996) Acc. Chem. Res. , vol.29 , pp. 503
    • Prestwich, G.D.1
  • 18
    • 26444582835 scopus 로고    scopus 로고
    • note
    • The observation of a phosphorus resonance at -5.65 ppm suggested the oxidation occurred selectively at the phosphorus atom.
  • 19
    • 0019890491 scopus 로고
    • Because of the abundance (ca. 20% of total viral proteins) and ease of detection by SDS-PAGE gel electrophoresis without any troublesome purification, HA has been selected as a protein substrate for this experiment. For the X-ray structure of HA, see, I. A. Wilson, J. J. Skehel and D. C. Wiley, Nature, 1981, 289, 366.
    • (1981) Nature , vol.289 , pp. 366
    • Wilson, I.A.1    Skehel, J.J.2    Wiley, D.C.3
  • 25
    • 26444489550 scopus 로고    scopus 로고
    • note
    • It might be assumed that both the sugar side chains modifying the extramembrane domain of HA and the viral membrane protect HA from the cleavage reaction by inhibition of the approach of Fe(III)-EDTA complex.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.