Alzheimer pathology associated with POLG1 mutation, multiple mtDNA deletions, and APOE4/4: Premature ageing or just coincidence? [2]

Acta Neuropathologica

Volumn 110, Issue 3, 2005, Pages 315-316

  Melberg, Atle ^a   Nennesmo, Inger ^b   Moslemi, Ali Reza ^c   Kollberg, Gittan ^c   Luoma, Petri ^d   Suomalainen, Anu ^d   Holme, Elisabeth ^c   Oldfors, Anders ^c  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CYSTEINE; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; TAU PROTEIN; TRANSFER RNA; TYROSINE;

ADULT; ALLELE; ALZHEIMER DISEASE; AUTOPSY; BRAIN ATROPHY; CASE REPORT; COGNITIVE DEFECT; CONTROLLED STUDY; DEATH; FAMILY STUDY; FEMALE; GENE DELETION; GENE MUTATION; GENETIC RISK; GENOTYPE; HETEROZYGOSITY; HISTOPATHOLOGY; HOMOZYGOSITY; HUMAN; HYPOKINESIA; IMMUNOHISTOCHEMISTRY; LETTER; MALE; MEMORY DISORDER; MITOCHONDRIAL MYOPATHY; MUSCLE BIOPSY; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PREMATURE AGING; PRIORITY JOURNAL; PSYCHOMETRY; RIGIDITY; SIBLING; SOMATIC MUTATION; SOUTHERN BLOTTING; SWEDEN;

AGE OF ONSET; AGING; AGING, PREMATURE; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FEMALE; GENE DELETION; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIAL MYOPATHIES; MUTATION; OPHTHALMOPLEGIA, CHRONIC PROGRESSIVE EXTERNAL; SIBLINGS; SWEDEN;

EID: 26444549892     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-005-1047-z     Document Type: Letter

References (6)

1. Calabrese V, Scapagnini G, Giuffrida Stella AM, Bates TE, Clark JB (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochem Res 26:739-764
2. Jorm AF, Korten AE, Henderson AS (1987) The prevalence of dementia: A quantitative integration of the literature. Acta Psychiatr Scand 76:465-479
3. Luoma P, Melberg A, Rinne JO, Kaukonen JA, Nupponen NN, Chalmers RM, Oldfors A, Rautakorpi I, Peltonen L, Majamaa K, Somer H, Suomalainen A (2004) Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: Clinical and molecular genetic study. Lancet 364:875-882
4. Moslemi AR, Melberg A, Holme E, Oldfors A (1996) Clonal expansion of mitochondrial DNA with multiple deletions in autosomal dominant progressive external ophthalmoplegia. Ann Neurol 40:707-713
5. Moslemi AR, Melberg A, Holme E, Oldfors A (1999) Autosomal dominant progressive external ophthalmoplegia: Distribution of multiple mitochondrial DNA deletions. Neurology 53:79-84
6. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-423