Effect of dexamethasone on postoperative cardiac troponin T production in pediatric cardiac surgery

Intensive Care Medicine

Volumn 31, Issue 10, 2005, Pages 1420-1426

  Malagon, Ignacio ^a   Hogenbirk, Karin ^a   Van Pelt, Johanes ^a   Hazekamp, Mark G ^a   Bovill, James G ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cardiac surgery; Dexamethasone; Pediatric; Troponin T

Indexed keywords

BIOLOGICAL MARKER; DEXAMETHASONE; TROPONIN T;

ANESTHESIA INDUCTION; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; HEART PROTECTION; HEART SURGERY; HUMAN; INFANT; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; PEDIATRIC SURGERY; POSTOPERATIVE PERIOD; PRESCHOOL CHILD; PROSPECTIVE STUDY; PROTEIN DETERMINATION; PROTEIN SYNTHESIS; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; UNIVERSITY HOSPITAL;

ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; MALE; POSTOPERATIVE PERIOD; TROPONIN T;

EID: 26444474991     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-005-2788-9     Document Type: Article

References (30)

1. El Habbal MH, Carter H, Smith LJ, Eliott M, Strobel S (1995) Neutrophil activation in paediatric extracorporeal circuits: effect of circulation and temporary variation. Cardiovasc Res 29:102-107
2. Brix-Christensen V (2001) The systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children. Acta Anaesthesiol Scand 45:671-679
3. Ashraf SS, Tian Y, Zacharrias S, Cowan D, Martin P, Watterson K (1997) Effect of cardiopulmonary bypass on neonatal and paediatric inflammatory profiles. Eur J Cardiothorac Surg 12:862-868
4. Tassani P, Richter JA, Barankay A, Braun SL, Haehnel C, Spaeth P, Schad H, Meisner H (1999) Does high-dose methylprednisolone in aprotinin-treated patients attenuate the systemic inflammatory response during coronary artery bypass grafting procedures? J Cardiothorac Vasc Anesth 13:165-172
5. Chaney MA (2002) Corticosteroids and cardiopulmonary bypass. A review of clinical investigations. Chest 121:921-931
6. Taggart DP, Hadjinikolas L, Wong K, Yap J, Hooper J, Kemp M, Hue D, Yacoub M, Lincoln JC (1996) Vulnerability of paediatric myocardium to cardiac surgery. Heart 76:214-217
7. Bronicki RA, Backer CL, Baden HP, Mavroudis C, Crawford SE, Green TP (2000) Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children. Ann Thorac Surg 69:1490-1495
8. Checchia PA, Backer CL, Bronicki RA, Baden HP, Crawford SE, Green TP, Mavroudis C (2003) Dexamethasone reduces postoperative troponin levels in children undergoing cardiopulmonary bypass. Crit Care Med 31:1742-1745
9. Schwartz SM, Duffy JY, Pearls JM, Goings S, Wagner CJ, Nelson DP (2003) Glucocorticoids preserve calpastatin and troponin I during cardiopulmonary bypass in immature pigs. Pediatr Res 54:91-97
10. Sasse S, Brand NJ, Kyprianou P, Dhoot GK, Wade R, Arai M, Periasamy M, Yacoub MH, Barton PJ (1993) Troponin I gene expression during human cardiac development and in end-stage heart failure. Circ Res 72:932-938
11. Kemp M, Donovan J, Higham H, Hooper J (2004) Biochemical markers of myocardial injury. Br J Anaesth 93:63-73
12. Immer FF, Stocker FP, Seiler AM, Pfammatter JP, Printzen G, Carrel TP (1998) Comparison of troponin-I and troponin-T after pediatric cardiovascular operation. Ann Thorac Surg 66:2073-2077
13. Kathiresan S, Servoss SJ, Newell JB, Trani D, Macgillivray TE, Lewandrowski K, Lee-Lewandrowski E, Januzzi Jr JL (2004) Cardiac troponin T elevation after coronary artery bypass grafting is associated with increased one-year mortality. Am J Cardiol 94:879-881
14. Malagon I, Hogenbirk K, Hazekamp MG, Bovill JG (2005) Effect of dexamethasone on postoperative cardiac troponin T production in paediatric cardiac surgery. Eur J Anaesthesiol 22 [Suppl 35]:O48
15. Altman DG (1994) Practical statistics for medical research, 1st edn. Chapman & Hall, London
16. Menasche P (1995) The inflammatory response to cardiopulmonary bypass and its impact on postoperative myocardial function. Curr Opin Cardiol 10:597-604
17. Immer FF, Stocker F, Seiler AM, Pfammatter JP, Printzen G, Peheim E (1997) Troponin-T; improved diagnostic assessment of myocardial damage in childhood. Acta Paediatr 86:1321-1327
18. Hovels-Gurich HH, Vazquez-Jimenez JF, Silvestri A, Schumacher K, Minkenberg R, Duchateua J, Messmer BJ, Bernuth G, Seghaye MC (2002) Production of proinflammatory cytokines and myocardial dysfunction after arterial switch operation in neonates with transposition of the great arteries. J Thorac Cardiovasc Surg 124:811-820
19. Nagy ZL, Collins M, Sharpe T, Mirsadraee S, Guerrero RR, Gibbs J, Watterson KG (2003) Effect of two different bypass techniques on the serum troponin-T levels in newborn and children. Does pH-stat provide better protection? Circulation 108:577-582
20. Hasegawa T, Yoshimura N, Oka S, Ootaki Y, Toyoda Y, Yamaguchi M (2004) Evaluation of heart fatty acid-binding protein as a rapid indicator for assessment of myocardial damage in pediatric cardiac surgery J Thorac Cardiovasc Surg 127:1697-1702
21. Imura H, Caputo M, Parry A, Pawade A, Angelini GD, Suleiman MS (2001) Age-dependent and hypoxia-related differences in myocardial protection during pediatric open heart surgery. Circulation 103:1551-1556
22. Lindberg L, Forsell C, Jogi P, Olsson AK (2003) Effects of dexamethasone on clinical course, C-reactive protein, S110B protein and von Willebrand factor antigen after paediatric cardiac surgery. Br J Anaesth 90:728-732
23. Butler J, Pathi VL, Paton RD, Logan RW, MacArthur KJD, Jamieson MPG, Pollock JCS (1996) Acute-phase response to cardiopulmonary bypass in children weighing less than 10 kilograms. Ann Thorac Surg 62:538-542
24. Schroeder VA, Pearl JM, Schwartz SM, Shanley TP, Manning PB, Nelson DP (2003) Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression. Circulation 107:2823-2828
25. Duffy JY, Nelson DP, Schwartz SM, Wagner CJ, Bauer SM, Lyons JM, McNamara JL, Pearl JM (2004) Glucocorticoids reduce cardiac dysfunction after cardiopulmonary bypass and circulatory arrest in neonatal piglets. Pediatr Crit Care Med 5:28-34
26. Lodge AJ, Chai PJ, Daggett CW, Ungerleider RM, Jaggers J (1999) Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: timing of dose is important. J Thorac Cardiovasc Surg 117:515-522
27. Mott AR, Fraser Jr CD, Kusnoor AV, Giesecke NM, Reul GJ Jr, Drescher KL, Watrin CH, O'Brian Smith E, Feltes TF (2001) The effect of short term prophylactic methylprednisolone on the incidence and severity of postpericardiotomy syndrome in children undergoing cardiac surgery with cardiopulmonary bypass. J Am Coll Cardiol 37:1700-1706
28. Lipshultz SE, Somers MJG, Lipsitz SR, Colan SD, Jabs K, Rifai N (2003) Serum cardiac troponin and subclinical cardiac status in pediatric chronic renal failure. Pediatrics 112:79-86
29. Pees C, Haas NA, von der Beek J, Ewert P, Berger F, Lange PE (2003) Cardiac troponin I is increased after interventional closure of atrial septal defects. Catheter Cardiovasc Interv 58:124-129
30. Modi P, Imura H, Angelini GD, Pawade A, Parry AJ, Suleiman MS, Caputo M (2003) Pathology-related troponin I release and clinical outcome after pediatric open heart surgery J Card Surg 18:295-300