In vitro models of multiple system atrophy

Movement Disorders

Volumn 20, Issue SUPPL. 12, 2005, Pages

  Stefanova, Nadia ^a   Reindl, Markus ^a   Poewe, Werner ^a   Wenning, Gregor K ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

synuclein; Glia; Glial cytoplasmic inclusions; Multiple system atrophy; Neurodegeneration

Indexed keywords

ALPHA SYNUCLEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CONTROLLED STUDY; GLIA CELL; IN VITRO STUDY; MOLECULAR MODEL; NERVE CELL CULTURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHY DRAGER SYNDROME; STATISTICAL SIGNIFICANCE; STRESS; WILD TYPE;

ALPHA-SYNUCLEIN; BASAL GANGLIA; BRAIN STEM; CEREBELLUM; DISEASE PROGRESSION; ENVIRONMENT; HUMANS; MICROGLIA; MULTIPLE SYSTEM ATROPHY; NERVE DEGENERATION; OXIDATIVE STRESS; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 26444433410     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.20540     Document Type: Article

References (13)

1. Wenning GK, Colosimo C, Geser F, Poewe W. Multiple system atrophy. Lancet Neurol 2004;3:93-103.
2. Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999;163:94-98.
3. Papp MI, Kahn JE, Lantos PL. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 1989;94:79-100.
4. Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M. Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 1998;251:205-208.
5. Gai WP, Power JH, Blumbergs PC, Culvenor JG, Jensen PH. Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components. J Neurochem 1999;73:2093-2100.
6. Solano SM, Miller DW, Augood SJ, Young AB, Penney JB. Expression of α-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson disease. Ann Neurol 2000;47:201-210.
7. Dickson DW, Lin W, Liu WK, Yen SH. Multiple system atrophy: a sporadic synucleinopathy. Brain Pathol 1999;9:721-732.
8. Stefanova N, Klimaschewski L, Poewe W, Wenning GK, Reindl M. Glial cell death induced by overexpression of alpha-synuclein. J Neurosci Res 2001;65:432-438.
9. Stefanova N, Emgard M, Klimaschewski L, Wenning GK, Reindl M. Ultrastructure of alpha-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells. Neurosci Lett 2002; 323:37-40.
10. Stefanova N, Schanda K, Klimaschewski L, Poewe W, Wenning GK, Reindl M. Tumor necrosis factor-alpha-induced cell death in U373 cells overexpressing alpha-synuclein. J Neurosci Res 2003; 73:334-340.
11. Gerhard A, Banati RB, Goerres GB, et al. [(11)C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology 2003;61:686-689.
12. Probst-Cousin S, Rickert CH, Schmid KW, Gullotta F. Cell death mechanisms in multiple system atrophy. J Neuropathol Exp Neurol 1998;57:814-821.
13. Seo JH, Rah JC, Choi SH, et al. Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB J 2002;16:1826-1828.