Differences in vertebral structure and strength of inbred female mouse strains

Journal of Musculoskeletal Neuronal Interactions

Volumn 4, Issue 1, 2004, Pages 33-40

  Akhter, M P ^a   Otero, J K ^a   Iwaniec, U T ^a   Cullen, D M ^a   Haynatzki, G R ^a   Recker, R R ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

B6; Bone strength; C3; D2; Density; Genetic; Histomorphometry; Mice; Strain; Vertebral body

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MINERAL; BONE STRENGTH; BONE STRUCTURE; CANCELLOUS BONE; COMPRESSION; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ELASTICITY; FEMALE; LUMBAR VERTEBRA; MECHANICAL STRESS; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOID; RIGIDITY; STRAIN DIFFERENCE; STRESS STRAIN RELATIONSHIP; TRABECULAR BONE; VERTEBRA BODY;

ANIMALS; BONE DENSITY; BONE DEVELOPMENT; CALCIFICATION, PHYSIOLOGIC; DENSITOMETRY, X-RAY; ELASTICITY; FEMALE; LUMBAR VERTEBRAE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; OSTEOCLASTS; SPECIES SPECIFICITY; STRESS, MECHANICAL; VARIATION (GENETICS); WEIGHT-BEARING;

EID: 2642588367     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S. Genetic determinants of bone mass in adults. A twin study. J Clin Invest 1987; 80(3):706-710.
2. Rogers J, Mahaney MC, Beamer WG, Donahue LR, Rosen CJ. Beyond one gene-one disease: alternative strategies for deciphering genetic determinants of osteoporosis. Calcif Tissue Int 1997; 60(3):225-228.
3. Slemenda CW, Christian JC, Reed T, Reister TK, Williams CJ, Johnston CC Jr. Long-term bone loss in men: effects of genetic and environmental factors. Ann Intern Med 1192; 117:286-291.
4. Smith DM, Nance WE, Kang KW, Christian JC, Johnston CC. Genetic factors in determining bone mass. J Clin Invest 1973; 52(11):2800-2808.
5. Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G. Genetic determinants of bone mineral content at the spine and radius: a twin study. Bone 1987; 8:207-209.
6. Ward LM, Rauch F, Travers R, Chabot G, Azouz EM, Lalic L, Roughley PJ, Glorieux FH. Osteogenesis imperfecta type VII: an autosomal recessive form of brittle bone disease. Bone 2002; 31(1):12-18.
7. Moller M, Horsman A, Harvald B, Hauge M, Henningsen K, Nordin BEC. Metacarpal morphometry in monozygotic and dizygotic elderly twins. Calcif Tissue Res 1978; 25:197-201.
8. Little RD, Carulli J, Del Mastro RG, Dupuis J, Osborne M, Folz C, Manning SP, Swain PM, Zhao SC, Eustace B, Lappe MM, Spitzer L, Zweier S, Braunschweiger K, Benchekroun Y, Hu X, Adair R, Chee L, FitzGerald MG, Tulig C, Caruso A, Tzellas N, Bawa A, Franklin B, McGuire S, Nogues X, Gong G, Allen KM, Anisowicz A, Morales AJ, Lomedico PT, Recker SM, VanEerdewegh P, Recker RR, Johnson ML. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 2002; 70:11-19.
9. Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR. Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tissue Int 1998; 63:442-449.
10. Akhter MP, Iwaniec UT, Covey MA, Cullen DM, Kimmel DB, Recker RR. Genetic variations in bone density, histomorphometry, and strength in mice. Calcif Tissue Int 2000; 67:337-349.
11. Beamer WG, Donahue LR, Rosen CJ, Baylink DJ. Genetic variability in adult bone density among inbred strains of mice. J Bone Min Res 1996; 18:397-403.
12. Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ. Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res 2001; 16(7):1195-1206.
13. Dimai H, Linkhart T, Linkhart S, Donahue L, Beamer W, Rosen C, Farley J, Baylink D. Alkaline phosphatase levels and osteoprogenitor cell number suggests bone volume differences between two inbred strains of mice. Bone 1998; 22(3):211-216.
14. Kodama Y, Dimai HP, Wegedal J, Sheng M, Malpe R, Kutilek S, Beamer W, Donahue LR, Rosen C, Baylink DJ, Farley J. Cortical tibial bone volume in two strains of mice: Effects of sciatic neurectomy and genetic regulation of bone response to mechanical loading. Bone 1999; 25(2):183-190.
15. Li X, Gu W, Masinde G, Hamilton-Ulland M, Rundle CH, Mohan S, Baylink DJ. Genetic variation in bone-regenerative capacity among inbred strains of mice. Bone 2001; 29:134-140.
16. Linkhart T, Linkhart S, Kodama Y, Farley J, Dimai H, Wright KR, Wergedal JE, Sheng M, Beamer W, Donahue L, Rosen C, Baylink D. Osteoclast formation in bone marrow cultures from two inbred strains of mice with different bone densities. J Bone Miner Res 1999; 14:39-46.
17. Pedersen EA, Akhter MP, Cullen DM, Kimmel DB, Recker RR. Bone response to in vivo mechanical loading in C3H/HeJ mice. Calcif Tissue Int 1999; 65:41-46.
18. Rosen CJ, Dimai HP, Vereault D, Donahue LR, Beamer WG, Farley J, Linkhart T, Linkhart S, Mohan S, Baylink DJ. Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities. Bone 1997; 21(3):217-223.
19. Sheng MHC, Baylink DJ, Beamer WG, Donahue LR, Rosen CJ, Lau KHW, Wergedal JE. Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than B6 (low density) mice during growth. Bone 1999; 25(4):421-429.
20. Turner CH, Hsieh YF, Muller R, Bouxsein ML, Rosen CJ, McCrann ME, Donahue LR, Beamer WG. Variation in bone biomechanical properties, microstructure, and density in BXH recombinant inbred mice. J Bone Miner Res 2001; 16(2):206-213.
21. Turner CH, Hsieh YF, Muller R, Bouxsein ML, Rosen CJ, McCrann ME, Donahue LR, Beamer WG. Variation in bone biomechanical properties, microstructure, and density in BXH recombinant inbred mice. J Bone Miner Res 2001; 16(2):206-213.
22. Sheng MHC, Baylink DJ, Beamer WG, Donahue LR, Lau KHW, Wergedal JE. Regulation of bone volume is different in the metaphyses of the femur and vertebra of C3H/HeJ and C57B1/6J mice. Bone 2002; 30(3):486-491.
23. Mein RF, Mitchell SR, Phillips TJ, Belknap JK, Orwoll ES. Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res 1998; 13:1648-1656.
24. Aron R, Vignery A, Neff L, Silverglate A, Santa Maria A. Processing of undecalcified bone specimens for bone histomorphometry. In: Recker RR (ed) Bone Histomorphometry: Techniques and Interpretation CRC Press, Boca Raton, Florida 1983:13-35.
25. Goldner J A. Modification of the Masson trichrome technique for routine laboratory purposes. Am J Pathol 1938; 14:237-243.
26. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluch H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units. J Bone Miner Res 1987; 2:595-610.
27. Baumeister T, Avallone EA. Marks' standard handbook for mechanical engineers. 9th Edition, McGraw-Hill, NY, 1986.
28. Turner CH. Yield behavior of cancellous bone. J Biomech Eng 1989: 111:1-5.
29. Newby JR. Mechanical Testing Handbook. The Material Information Society, ASM, Volume 8-1992.
30. Van Der Meulen MCH, Jepsen KJ, Mikic B. Understanding bone strength: size isn't everything. Bone 2001; 29(2):101-104.
31. Conover, WJ. Practical Nonparametric Statistics, 2nd ed. New York: John Wiley and Sons, Inc., 1980.