Benign epileptiform discharges of childhood (Rolandic spikes) - Neurobiological and neuropsychological findings and their clinical significance in child and adolescent psychiatry;Benigne epilepsietypische potentiale des kindesalters (Rolando-spikes) - Neurobiologische und neuropsychologische befunde und ihre klinische bedeutung in der kinder- und jugendpsychiatrie

Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie

Volumn 32, Issue 2, 2004, Pages 117-129

  Holtmann, Martin ^a   Becker, K ^b   El Faddagh, M ^b   Schmidt, M H ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Klin F Psychiat Psychotherapie K   (Germany)

Author keywords

Benign epileptiform discharges; Brain maturation; Cognitive impairment; Neuropsychological deficit; Rolandic epilepsy

Indexed keywords

BRAIN MATURATION; BRAIN RADIOGRAPHY; CHILD BEHAVIOR; CHILD DEVELOPMENT; CHILD PSYCHIATRY; COGNITIVE DEFECT; ELECTROENCEPHALOGRAM; EPIDEMIOLOGICAL DATA; HUMAN; MENTAL DISEASE; MODEL; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROPSYCHOLOGY; PROGNOSIS; PUBERTY; REVIEW; ROLANDIC EPILEPSY; SPIKE WAVE;

ADOLESCENT; CEREBRAL CORTEX; CHILD; CHILD BEHAVIOR DISORDERS; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; EPILEPSY, ROLANDIC; EVOKED POTENTIALS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; LANGUAGE DEVELOPMENT DISORDERS; LEARNING DISORDERS; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; PROGNOSIS; RISK; TWIN STUDIES;

EID: 2642573543     PISSN: 14224917     EISSN: None     Source Type: Journal    
DOI: 10.1024/1422-4917.32.2.117     Document Type: Review

References (82)

1. Aldenkamp, A. P. (1997). Effect of seizures and epileptiform discharges on cognitive function. Epilepsia 38, Suppl. 1, 52-55.
2. Ambrosetto, G. (1992). Unilateral opercular macrogyria and benign childhood epilepsy with centrotemporal (rolandic) spikes: report of a case. Epilepsia 33, 499-503.
3. Baglietto, M. G., Battaglia, F. M., Nobili, L., Tortorelli, S., De Negri, E., Caleva, M. G., Veneselli, E., & De Negri, M. (2001). Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes. Developmental Medicine and Child Neurology 43(6), 407-412.
4. Besag, F. M. (2002). Childhood epilepsy in relation to mental handicap and behavioural disorders. Journal of Child Psychology and Psychiatry 43, 103-131.
5. Binnie, C. D. & Marston, D. (1992). Cognitive correlates of interictal discharges. Epilepsia 33, Suppl. 6, 11-17.
6. Bouma, P. A., Bovenkerk, A. C., Westendorp, R. G., & Brouwer, O. F. (1997). The course of benign partial epilepsy with centrotemporal spikes: a meta-analysis. Neurology 48(2), 430-437.
7. Braga, N. I. O., Manzano, G. M., & Nóbrega, J. A. M. (2000). Quantitative analysis of EEG background activity in patients with rolandic spikes. Clinical Neurophysiology 111, 1643-1645.
8. Carlsson, G., Igelbrink-Schulze, N., Neubauer, B. A., & Stephani, U. (2000). Neuropsychological long-term outcome of rolandic EEG traits. Epileptic Disorders 2 (Suppl. 1), 63-66.
9. Cavazutti, G. B., Cappella, L., & Nalin, A. (1980). Longitudinal study of epileptiform EEG patterns in normal children. Epilepsia 21, 43-55.
10. Chevalier, H., Metz-Lutz, M. N., & Segalowitz, S. J. (2000). Impulsivity and Control of Inhibition in Benign Focal Childhood Epilepsy (BFCE). Brain and Cognition 43, 86-90.
11. Commission on classification and terminology of the International League Against Epilepsy (1989). Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 30, 389-399.
12. Croona, C., Kihlgren, M., Lundberg, S., Eeg-Olofsson, O., & Eeg-Olofsson, K. E. (1999). Neuropsychological findings in children with benign childhood epilepsy with centrotemporal spikes. Developmental Medicine and Child Neurology 41, 813-818.
13. Dalla Bernardina, B., Sgro, V., Caraballo, R., Fontana, E., Colamaria, V., Zullini, E., Simone, M., & Zanetti, R. (1991). Sleep and benign partial epilepsies of childhood: EEG and evoked potentials study. Epilepsy Research Suppl. 2, 83-96.
14. De Marco, P., & Tassinari, C. A. (1981). Extreme somatosensory evoked potentials (ESEP): an EEG sign forecasting the possible occurrence of seizures in children. Epilepsia 22, 569-575.
15. De Negri, M. (1997). Electrical status epilepticus during sleep (ESES). Different clinical syndromes: towards a unifying view? Brain and Development 19(7), 447-451.
16. Deonna, T. W., Roulet, E., Fontan, D., & Marcoz, J. P. (1993). Speech and oromotor deficits of epileptic origin in benign partial epilepsy of childhood with rolandic spikes (BPERS). Relationship to the acquired aphasia-epilepsy syndrome. Neuropediatrics 24, 83-87.
17. Deonna, T., Zesiger, P., Davidoff, V., Maeder, M., Mayor, C., & Roulet, E. (2000). Benign partial epilepsy of childhood: a longitudinal neuropsychological and EEG study of cognitive function. Developmental Medicine and Child Neurology 42, 595-603.
18. Doose, H. (1998). Epilepsien im Kindes- und Jugendalter. 11. Aufl; Hamburg: Desitin.
19. Doose, H., & Baier, W. K. (1989). Benign partial epilepsies and related syndromes - multifactorial pathogenesis with hereditary impairment of brain maturation. European Journal of Pediatrics 149, 152-158.
20. Doose H., Brigger-Heuer B., & Neubauer B. (1997). Children with focal sharp waves: clinical and genetic aspects. Epilepsia 38, 788-796.
21. Doose, H., Neubauer, B., & Carlsson, G. (1996). Children with Benign Focal Sharp Waves in the EEG - Developmental Disorders and Epilepsy. Neuropediatrics 27, 227-241.
22. Doose, H., & Neuhäuser, G. (1997). Gutartige Epilepsieformen und neuropsychologische Beeinträchtigungen bei erblichen Hirneifungsstörungen. Kindheit und Entwicklung 6, 48-58.
23. Dulac, O. (2001). Epileptic encephalopathy. Epilepsia 42, Suppl. 3, 23-26.
24. Eeg-Olofsson, O., Lundberg, S., & Raininko, R. (2000). MR1 in rolandic epilepsy. Epileptic Disorders 2, Suppl. 1, 51-53.
25. Eeg-Olofsson, O., Petersen, I., & Sellden, U. (1971). The development of the electroencephalogram in normal children from the age of 1 through 15 years. Paroxysmal activity. Neuropediatrics 2, 375-404.
26. Engel, J. J. (1996). Excitation and inhibition in epilepsy. Canadian Journal of Neurological Sciences 23, 167-174.
27. Fejerman, N., Caraballo, R., & Tenembaum, S. N. (2000). Atypical evolutions of benign localization-related epilepsies in children: are they predictable? Epilepsia 41(4), 380-390.
28. Ferri, R., Del Gracco, S., Elia, M., & Musumeci, S. A. (2000). Age-related changes of cortical excitability in subjects with sleep-enhanced centrotemporal spikes: a somatosensory evoked potential study. Clinical Neurophysiology 111, 591-599.
29. Frank, Y. (1993). Visual event related potentials after methylphenidate and sodium valproate in children with attention deficit hyperactivity disorder. Clinical Electroencephalography 24(1), 19-24.
30. Freedman, R., Coon, H., Myles-Worsley, M., Orr-Urtreger, A., Olincy, A., Davis, A., Polymeropoulos, M., Holik, J., Hopkins, J., Hoff, M., Rosenthal, J., Waldo, M. C., Reimherr, F., Wender, P., Yaw, J., Young, D. A., Breese, C. R., Adams, C., Patterson, D., Adler, L. E., Kruglyak, L., Leonard, S., & Byerley, W. (1997). Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proceedings of the National Academy of Sciences 94, 587-592.
31. Gasser, T., Verleger, R., Bacher, P., & Sroka, L. (1988). Development of the EEG of school-age children and adolescents. I. Analysis of band power. Electroencephalography and Clinical Neurophysiology 69, 91-99.
32. Gelisse, P., Corda, D., Raybaud, C., Dravet, C., Bureau, M., & Genton, P. (2003). Abnormal neuroimaging in patients with benign epilepsy with centrotemporal spikes. Epilepsia 44(3), 372-378.
33. Gonzalez-Garrido, A. A., Oropeza de Alba, J. L., Gomez-Velazquez, F. R., Fernandez Harmony, T., Soto Mancilla, J. L., Ceja Moreno, H., Perez Rulfo, D., Gonzalez Cornejo, S., Riestra Castneda, R., Aguirre Portillo, L. E., Gomez Limon, E., & Ruiz Sandoval, J. L. (2000). Transitory cognitive impairment in epileptic children during a CPT task. Clinical Electroencephalography 31(4), 175-180.
34. Gross-Selbeck, G. (1995). Treatment of «benign» partial epilepsies of childhood, including atypical forms. Neuropediatrics 26, 45-50.
35. Gross-Tsur, V., Manor, O., van der Meere, J., Joseph, A., & Shalev, R. S. (1997). Epilepsy and attention deficit hyperactivity disorder: is methylphenidate safe and effective? Journal of Pediatrics 130, 670-674.
36. Gucuyener, K., Erdemoglu, A. K., Senol, S., Serdaroglu, A., Soysal, S., & Kockar, A. I. (2003). Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities. Journal of Child Neurology 18(2), 109-112.
37. Gülgönen, S., Demirbilek, V., Korkmaz, B., Dervent, A., & Townes, B. D. (2000). Neuropsychological Functions in Idiopathic Occipital Lobe Epilepsy. Epilepsia 41(4), 405-411.
38. Gündüz, E., Demirbilek, V., & Korkmaz, B. (1999). Benign rolandic epilepsy: neuropsychological findings. Seizure 8, 246-249.
39. Hahn, A., Pistohl, J., Neubauer, B. A., & Stephani, U. (2001). Atypical «enign» partial epilepsy or pseudo-Lennox syndrome. Part 1: symptomatology and long-term prognosis. Neuropediatrics 32, 1-8.
40. Hemmer, S. A., Pasternak, J. F., Zecker, S. G., & Trommer, B. L. (2001). Stimulant therapy and seizure risk in children with ADHD. Pediatric Neurology 24(2), 99-102.
41. Holtmann, M., Becker, K., Kentner-Figura, B., & Schmidt, M. H. (2003). Increased frequency of rolandic spikes in ADHD-children. Epilepsia 44(9), 1241-1244.
42. Holtmann, M., & Schmidt, M. H. (2003). Behavior problems in nonepileptic children with rolandic epileptiform discharges. (letter). Epilepsia 44(6), 875.
43. Hommet, C., Billard, C., Motte, J., Passage, G. D., Perrier, D., Gillet, P., Prunier, C., Toffol, B. D., & Autret, A. (2001). Cognitive function in adolescents and young adults in complete remission from benign childhood epilepsy with centro-temporal spikes. Epileptic Disorders 3(4), 207-216.
44. Hongo, K., Naganuma, Y., Murakami, M., Yamatani, M., Okuda, T., Konishi, T., & Okada, T. (1990). Development of EEG background activity in children with benign partial epilepsy. Japanese Journal of Psychiatry and Neurology 44, 367-368.
45. Jung, M., Gabriel, K. H., & Stolle, D. (2000). Das ESES-Syndrom in der Kinder- und Jugendpsychiatrie. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 28(1), 17-24.
46. Konishi, T., Naganuma, Y., Hongou, K., Murakami, M., Yamatani M., & Yagi, S. (1995). Changes of P300 latency with age in childhood epilepsy. Pediatric Neurology 12(2), 132-135.
47. Lombroso, C. T. (1967). Sylvian seizures and midtemporal spike foci in children. Archives of Neurology 17, 52-59.
48. Lüders, H., Lesser, R. P., Dinner, D. S., & Moris III, H. H. (1987). Benign focal epilepsies of childhood. In: Lüders, H., Lesser, R. P. (Eds.) Epilepsy: Electroclinical syndromes. London, Berlin, Heidelberg, New York, Paris, Tokyo: Springer, 303-346.
49. Lundberg, S., Weis, J., Eeg-Olofsson, O., & Raininko, R. (2003). Hippocampal Region Asymmetry Assessed by 1H-MRS in Rolandic Epilepsy. Epilepsia 44, 205-210.
50. Maquet, P., Metz-Lutz, M. N., Saint-Martin, A. D., Marescaux, C., & Hirsch, E. (2000). Isotope tracer-techniques in rolandic epilepsy and its variants. Epileptic Disorders 2 (Suppl. 1), 55-57.
51. Marston, D., Besag, F., Binnie, C. D., & Fowler, M. (1993). Effects of transitory cognitive impairment on psychosocial functioning in children with epilepsy: a therapeutic trial. Developmental Medicine and Child Neurology 35(7), 574-581.
52. Massa, R., de Saint-Martin, A., Carcangiu, R., Rudolf G., Seegmuller, C., Kleitz, C., Metz-Lutz, M. N., Hirsch, E., & Marescaux, C. (2001). EEG criteria predictive of complicated evolution in idiopathic rolandic epilepsy. Neurology 57, 1071-1079.
53. Matoth, I., Taustein, I., Kay, B. S., & Shapira, Y. A. (2002). Overuse of EEG in the evaluation of common neurologic conditions. Pediatric Neurology 27(5), 378-383.
54. Metz-Lutz, M. N., Kleitz, C., Saint Martin, A. de, Massa, R., Hirsch, E., & Marescaux, C. (1999). Cognitive Development in Benign Focal Epilepsies of Childhood. Developmental Neuroscience 21, 182-190.
55. Meusers, M. (1993). Entwicklungsprobleme bei Kindern mit «benignen» Partialepilepsien. In: Gross-Selbeck, G. (Hrsg.), Die sogenannten benignen Partialepilepsien im Kindesalter. Das anfallskranke Kind Bd 8, 45-49. Hamburg: Edition m+p.
56. Morrel, F., Whisler, W. W., & Smith, M. C. (1995). Landau-Kleffner syndrome. Treatment with subpial intracortical transection. Brain 118, 1529-1546.
57. Naganuma, Y., Konishi, T., Hongue, K., Tohyama, J., & Uchiyama, M. (1997a). Epileptic seizures and event-related potentials (P300) in childhood partial epilepsies. Clinical Electroencephalography 28(2), 106-111.
58. Naganuma, Y., Konishi, T., Hongue, K., Tohyama, J., & Uchiyama, M. (1997b). Event-related potentials (P300) and EEG activity in childhood partial epilepsy. Brain and development 19(2), 117-121.
59. Neubauer, B. A. (2000). The genetics of rolandic epilepsy. Epileptic Disorders 2 (Suppl. 1), 67-68.
60. Neubauer, B. A., Fiedler, B., Himmelein, B., Kämpfer, F., Lässker, U., Schwabe, G., Spanier, I., Tams, D., Bretscher, C., Moldenhauer, K., Kurlemann, G., Weise, S., Tedroff, K., Eeg-Olofsson, O., Wadelius, C., & Stephani, U. (1998). Centrotemporal spikes in families with rolandic epilepsy. Linkage to chromosome 15q14. Neurology 51, 1608-1612.
61. Neubauer, B. A., Hahn, A., Stephani, U., & Doose, H. (2002). Clinical spectrum and genetics of Rolandic epilepsy. Advances in Neurology 89, 475-479.
62. Opp, J., Wenzel, D., & Brandl, U. (1992). Visuomotor coordination during focal and generalized EEG discharges. Epilepsia 33(5), 836-840.
63. Pan, A., & Lüders, H. O. (2000). Epileptiform discharges in benign focal epilepsy of childhood. Epileptic Disorders 2 (Suppl. 1), 29-36.
64. Piccirilli, M., D'Alessandro, P., Sciarma, T., Cantoni, C., Dioguardi, M. S., Giuglietti, M., Ibba, A., & Tiacci, C. (1994). Attention problems in epilepsy: possible significance of the epileptogenic focus. Epilepsia 35(5), 1091-1096.
65. Piccirilli, M., D'Alessandro, P., Tiacci, C., & Ferroni, A. (1988). Language lateralization in children with benign partial epilepsy. Epilepsia 29(1), 19-25.
66. Plasmati, R., Michelucci, R., Forti, A., Rubboli, G., Salvi, F., Saba, E., & Tassinari, C. A. (1992). The neurophysiological features of benign partial epilepsy with rolandic spikes. Epilepsy Research Suppl. 6, 45-48.
67. Pott, W., & Remschmidt, H. (1996). Fokale hypersynchrone Aktivität im EEG bei Kindern mit Teilleistungsstörungen: besteht eine klinische Relevanz? Zeitschrift für Kinder- und Jugendpsychiatrie 24, 272-281.
68. Rating, D., Wolf, C., & Bast, T. for the Sulthiame Study Group. (2000). Sulthiame as Monotherapy in Children with Benign Childhood Epilepsy with Centrotemporal Spikes: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study. Epilepsia 41(10), 1284-1288.
69. Saint-Martin, A. D., Petiau, C., Massa, R., Maquet, P., Marescaux, C., Hirsch, E., & Metz-Lutz, M. N. (1999). Idiopathic rolandic epilepsy with «interictal» facial myoklonia and oromotor deficit: a longitudinal EEG and PET study. Epilepsia 40, 614-620.
70. Scheffer, I. E. (2000). Autosomal dominant rolandic epilepsy with speech dyspraxia. Epileptic Disorders 2 (Suppl. 1), 19-22.
71. Scheffer, I. E., Jones, L., Pozzebon, M., Howell, R. A., Saling, M. M., & Berkovic, S. F. (1995). Autosomal dominant rolandic epilepsy and speech dyspraxia: a new syndrome with anticipation. Annals of Neurology 38, 633-642.
72. Schmidt, J. K., Plück, J., & von Gontard, A. (2002). Verzicht auf eine EEG-Diagnostik vor Beginn und unter einer Therapie mit Methylphenidat: gefährlich oder gerechtfertigt? Zeitschrift für Kinder- und Jugendpsychiatrie und -psychotherapie 30, 295-302.
73. Sheth, R. D., Gutierrez, A. R., & Riggs, J. E. (1997). Rolandic epilepsy and cortical dysplasia: MRI correlation of epileptiform discharges. Pediatric Neurology 17, 177-179.
74. Shewmon, D. A., & Erwin, R. J. (1988). Focal spike-induced cerebral dysfunction is related to the after-coming slow-wave. Annals of Neurology 23, 131-137.
75. Staden, U., Isaacs, E., Boyd, S. G., Brandl, U., & Neville, B. G. R. (1998). Language Dysfunction in Children with Rolandic Epilepsy. Neuropediatrics 29, 242-248.
76. Steinlein, O. K. (2001). Genes and mutations in idiopathic epilepsy. American Journal of Medical Genetics 106, 139-145.
77. Steinlein, O. K., Neubauer, B. A., Sander, T., Song, L., Stoodt, J., & Mount, D. B. (2001). Mutation analysis of the potassium chloride cotransporter KCC3 (SLC12A6) in rolandic and idiopathic generalized epilepsy. Epilepsy Research 44(2-3), 191-195.
78. Stephani, U., & Doose, H. (1999). Benign idiopathic partial epilepsy and brain lesion. Epilepsia 40, 373-6.
79. van der Meij, W., van Huffelen, A. C., Willemse, J., Schenk-Rootlieb, A. J., & Meiners, L. C. (1992). Rolandic spikes in the inter-ictal EEG of children: contribution to diagnosis, classification and prognosis of epilepsy. Developmental Medicine and Child Neurology 34(10), 893-903.
80. Weglage, J., Demsky, A., Pietsch, M., & Kurlemann, G. (1997). Neuropsychological, intellectual, and behavioral findings in patients with centrotemporal spikes with and without seizures. Developmental Medicine and Child Neurology 39, 646-651.
81. Woerner, W., Rothenberger, A., & Lahnert, B. (1987). Test-retest reliability of spectral parameters of the resting EEG in a field sample: a 5 year follow-up in schoolchildren with and without psychiatric disturbances. Electroencephalography and Clinical Neurophysiology 40 (Suppl.), 629-632.
82. Yung, A. W. Y., Park, Y. D., Cohen, M. J., & Garrison, T. N. (2000). Cognitive and Behavioral Problems in Children with Centrotemporal Spikes. Pediatric Neurology 23, 391-395.