Intronic polymorphism of tryptophan hydroxylase and serotonin transporter: Indication for combined effect in predisposition to suicide

Journal of Neural Transmission

Volumn 111, Issue 6, 2004, Pages 733-738

  Jernej, B ^a   Stefulj, J ^a   Hranilovic, D ^a   Balija, M ^b   Skavic, J ^c   Kubat, M ^c  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b CROATIAN INSTITUTE OF TRANSFUSION MEDICINE   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

5HTt; Concurrence; Serotonin; Slavic ethnicity; Suicide completion; TPH

Indexed keywords

SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMISSION; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SUICIDE;

CARRIER PROTEINS; CROATIA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTRONS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUICIDE; TRYPTOPHAN HYDROXYLASE;

EID: 2642568748     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-003-0114-7     Document Type: Article

References (18)

1. Abbar M, Courtet P, Bellivier F, Leboyer M, Boulanger JP, Castelhau D, et al. (2001) Suicide attempts and the tryptophan hydroxylase gene. Mol Psychiatry 6: 268-273
2. Asberg M, Forslund K (2000) Neurobiological aspects of suicidal behavior. Int Rev Psych 12: 62-74
3. Bondy B, Baghai TC, Zill P, Bottlender R, Jaeger M, Minov C, et al. (2002) Combined action of the ACE D- and the G-protein 3 T-allele in major depression: a possible link to cardiovascular disease? Mol Psychiatry 7: 1120-1126
4. De Castro IP, Ibanez A, Saiz-Ruiz J, Fernandez-Piqueras J (2002) Concurrent positive association between pathological gambling and functional DNA polymorphisms at the MAO-A and the 5-HT transporter genes. Mol Psychiatry 7: 927-928
5. Fiskerstrand CE, Lovejoy EA, Quinn JP (1999) An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett 458: 171-174
6. Hranilovic D, Schwab SG, Jernej B, Knapp M, Lerer B, Albus M, et al. (2000) Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings. Mol Psychiatry 5: 91-95
7. Hranilovic D, Stefulj J, Furac I, Kubat M, Balija M, Jernej B (2003) Serotonin transporter promoter (5HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victims. Biol Psychiatry 54: 884-889
8. Lalovic A, Turecki G (2002) Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. Am J Med Genet 114: 533-540
9. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P (1994) Organization of the human serotonin transporter gene. J Neural Transm 95: 157-162
10. MacKenzie A, Quinn J (1999) A serotonin transporter gene intron 2 polymorphic region correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 96: 15251-15255
11. Mann JJ, Brent D, Arango V (2001) The neurobiology and genetics of suicide and attempted suicide: a focus on serotonergic system. Neuropsychopharmacol 24: 467-477
12. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D (1997) Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Mol Brain Res 45: 145-148
13. Ono H, Shirakawa O, Kitamura N, Hashimoto T, Nishiguchi N, Nishimura A, et al. (2002) Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls. Mol Psychiatry 7: 1127-1132
14. Paolini-Giacobino A, Mouthon D, Lambercy C, Vessaz M, Coutant-Zimmerli S, Rudolph W, et al. (2000) Identification and analysis of new sequence variants in the human tryptophan hydroxylase (TPH) gene. Mol Psychiatry 5: 49-55
15. Roy A (2001) Genetic influence on suicide risk. Clin Neurosci Res 1: 324-330
16. Stefulj J, Furac I, Hranilovic D, Kubat M, Jernej B (2000) Tryptophan hydroxylase gene polymorphism (A218C) in suicide victims. Am J Med Genet 96: 559
17. Turecki G (2001) Suicidal behavior: is there a genetic predisposition? Bipol Disord 3: 335-349
18. Walther DJ, Peter JU, Bashammakh S, Hoertnagl H, Voits M, Fink H, Bader M (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299: 76