Antagonism of the α4 integrin subunit attenuates the acute inflammatory response to stent implantation yet is insufficient to prevent late intimal formation

Journal of Leukocyte Biology

Volumn 75, Issue 6, 2004, Pages 1016-1021

  Ma, Xiaoli ^a   O'Brien, Edward R ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

Adhesion; Leukocyte; Restenosis

Indexed keywords

ALPHA4 INTEGRIN; INTEGRIN; BLOCKING ANTIBODY; MONOCLONAL ANTIBODY; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; IMPLANTATION; INFLAMMATION; INTIMA; LEUKOCYTE ADHERENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STENT; ANIMAL; COMPARATIVE STUDY; GRAFT OCCLUSION; ILIAC ARTERY; IMMUNOLOGY; INJURY; MACROPHAGE; MALE; MONOCYTE; PATHOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; VASCULITIS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANGIOPLASTY, BALLOON; ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; GRAFT OCCLUSION, VASCULAR; HYPERCHOLESTEROLEMIA; ILIAC ARTERY; INTEGRIN ALPHA4BETA1; MACROPHAGES; MALE; MONOCYTES; RABBITS; STENTS; TUNICA INTIMA; VASCULITIS;

EID: 2642553248     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1203618     Document Type: Article

References (31)

1. Colombo, A., Stankovic, G., Moses, J. W. (2002) Selection of coronary stents. J. Am. Coll. Cardiol. 40, 1021-1033.
2. Glover, C., O'Brien, E. R. (2000) Pathophysiological insights from studies of retrieved coronary atherectomy tissue. Semin. Interv. Cardiol. 5, 167-173.
3. Meuwissen, M., Van der Wal, A. C., de Winter, R. J., Koch, K. T., Becker, A. E., Piek, J. J. (2002) Images in cardiovascular medicine. Stent inflammation: stent footprint in restenotic tissue retrieved by directional atherectomy. Circulation 106, 1176-1177.
4. Farb, A., Sangiorgi, G., Carter, A. J., Walley, V. M., Edwards, W. D., Schwartz, R. S., Virmani, R. (1999) Pathology of acute and chronic coronary stenting in humans. Circulation 99, 44-52.
5. Kornowski, R., Hong, M. K., Tio, F. O., Bramwell, O., Wu, H., Leon, M. B. (1998) In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia. J. Am. Coll. Cardiol. 31, 224-230.
6. Welt, F. G. P., Rogers, C. (2002) Inflammation and restenosis in the stent era. Arterioscler. Thromb. Vasc. Biol. 22, 1769-1776.
7. Lobb, R. R., Hemler, M. E. (1994) The pathophysiologic role of α4 integrins in vivo. J. Clin. Invest. 94, 1722-1728.
8. Molossi, S., Elices, M., Arrhenius, T., Diaz, R., Coulber, C., Rabinovitch, M. (1995) Blockade for very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts. J. Clin. Invest. 95, 2601-2610.
9. Elices, M. J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M. E., Lobb, R. R. (1990) VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584.
10. O'Brien, K. D., Allen, M. D., McDonald, T. O., Chait, A., Harlan, J. M., Fishbein, D., McCarty, J., Ferguson, M., Hudkins, K., Benjamin, C. D. (1993) Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J. Clin. Invest. 92, 945-951.
11. Patel, S. S., Thiagarajan, R., Willerson, J. T., Yeh, E. T. (1998) Inhibition of α4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in apoE-deficient mice. Circulation 97, 75-81.
12. Shih, P. T., Brennan, M-L., Vora, D. K., Territo, M. C., Strahl, D., Elices, M. J., Lusis, A. J., Berliner, J. A. (1999) Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet. Circ. Res. 84, 345-351.
13. Kling, D., Fingerle, J., Harlan, J. M., Lobb, R. R., Lang, F. (1995) Mononuclear leukocytes invade rabbit arterial intima during thickening formation via CD18- and VLA-4-dependent mechanisms and stimulate smooth muscle migration. Circ. Res. 77, 1121-1128.
14. Labinaz, M., Hoffert, C., Pels, K., Aggarwal, S., Pepinsky, R. B., Leone, D., Koteliansky, V., Lobb, R. R., O'Brien, E. R. (2000) Infusion of an antiα4 integrin antibody is associated with less neoadventitial formation after balloon injury of porcine coronary arteries. Can. J. Cardiol. 16, 187-196.
15. Lumsden, A. B., Chen, C., Hughes, J. D., Kelly, A. B., Hanson, S., Harker, L. (1997) Anti-VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in non-human primates. J. Vasc. Surg. 26, 87-93.
16. Pulido, R., Elices, M. J., Campanero, M. R., Osborn, L., Schiffer, S., Garcia-Pardo, A., Lobb, R., Hemler, M. E., Sanchez-Madrid, F. (1991) Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. J. Biol. Chem. 266, 10241-10245.
17. Winn, R. K., Harlan, J. M. (1993) CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits. J. Clin. Invest. 92, 1168-1173.
18. Ma, X., Glover, C., Miller, H., Goldstein, J., O'Brien, E. (2001) Focal arterial transgene expression after local gene delivery. Can. J. Cardiol. 17, 873-883.
19. Palmaz, J. C., Windeler, S. A., Garcia, F., Tio, F. O., Sibbitt, R. R., Reuter, S. R. (1986) Atherosclerotic rabbit aortas: expandable intraluminal grafting. Radiology 160, 723-726.
20. Hehrlein, C., Gollan, C., Donges, K., Metz, J., Riessen, R., Fehsenfeld, P., von Hodenberg, E., Kubler, W. (1995) Low-dose radioactive endovascular stents prevent smooth muscle cell proliferation and neointimal hyperplasia in rabbits. Circulation 92, 1570-1575.
21. Schwartz, R. S., Huber, K. C., Murphy, J. G., Edwards, W. D., Camrud, A. R., Vlietstra, R. E., Holmes, D. R. (1992) Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J. Am. Coll. Cardiol. 19, 267-274.
22. Weinreb, P. H., Yang, W. J., Violette, S. M., Couture, M., Kimball, K., Pepinsky, R. B., Lobb, R. R., Josiah, S. (2002) A cell-free electrochemiluminescence assay for measuring β1-integrin-ligand interactions. Anal. Biochem. 306, 305-313.
23. Froeschl, M., Olsen, S., Ma, X., O'Brien, E. R. (2004) Current understanding of in-stent restenosis and the potential benefit of drug eluting stents. Curr. Drug Targets Cardiovasc. Haematol. Disord. 4, 103-117.
24. Saiura, A., Sata, M., Hirata, Y., Nagai, R., Makuuchi, M. (2001) Circulating smooth muscle progenitor cells contribute to atherosclerosis. Nat. Med. 7, 382-383.
25. Hibbert, B., Olsen, S., O'Brien, E. R. (2003) Involvement of progenitor cells in vascular repair. Trends Cardiovasc. Med. 13, 322-326.
26. Rogers, C., Edelman, E. B., Simon, D. I. (1998) A mAb to the B2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or sent implantation in rabbits. Proc. Natl. Acad. Sci. USA 95, 10134-10139.
27. Tanaka, H., Sukhova, G. K., Swanson, S. J., Clinton, S. K., Ganz, P., Cybulsky, M. I., Libby, P. (1993) Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury. Circulation 88, 1788-1803.
28. Cybulsky, M. I., Gimbrone, M. A. (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788-791.
29. Li, H., Cybulsky, M. I., Gimbrone, M. A., Libby, P. (1993) An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler. Thromb. 12, 197-204.
30. Oguchi, S., Dimayuga, P., Zhu, J., Chyu, K. Y., Yano, J., Shah, P. K., Nilsson, J., Cercek, B. (2000) Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. Arterioscler. Thromb. Vasc. Biol. 20, 1729-1736.
31. 4 and vascular cell adhesion molecule-1 during smooth muscle cell differentiation. Circ. Res. 80, 159-169.