A retrospective analysis of selected neoplastic markers (p53, PCNA, Ki67, DNA) and ultrastructure in patients with laryngeal cancer;Retrospektive analyse ausgewahlter tumormarker (p53, PCNA, Ki67; DNA- ploidie) und der ultrastruktur bei kranken mit larynxkarzinomen

HNO

Volumn 46, Issue 3, 1998, Pages 233-240

  Golusinski W ^a,d   Szmeja, Z ^a   Olofsson, J ^b   Biczysko, W ^a   Krygier Stojalzowska A ^c   Majewski, P ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c University School of Medicine   (Poland)

^d NONE   (Poland)

Author keywords

DNA ploidy; Laryngeal cancer; Oncogenes; Proliferative markers

Indexed keywords

CYCLINE; DNA; KI 67 ANTIGEN; PROTEIN P53; TUMOR MARKER;

ADULT; AGED; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; CANCER LOCALIZATION; CANCER STAGING; CELL ULTRASTRUCTURE; DIAGNOSTIC VALUE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CANCER; MAJOR CLINICAL STUDY; PLOIDY; CELL DIVISION; CELL NUCLEUS; CELL TRANSFORMATION; ENZYME IMMUNOASSAY; LARYNX; LARYNX TUMOR; NUCLEOLUS; PHYSIOLOGY; PROGNOSIS; ULTRASTRUCTURE;

CELL DIVISION; CELL NUCLEOLUS; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; DNA, NEOPLASM; HUMANS; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; LARYNGEAL NEOPLASMS; LARYNX; NEOPLASM STAGING; PLOIDIES; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031596879     PISSN: 00176192     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001060050231     Document Type: Article

References (33)

1. Anwar K, Nakakuki K, Imai H, Naiki H, Inzuzuka M (1993) Overexpression of p53 protein in human laryngeal carcinoma. Int J Cancer 53:952-956
2. Boag G, Lee CS, Charalambous D, Rode J (1993) p53 expression in laryngeal carcinoma. Pathology 25:394-397
3. Böcking A (1990) DNA-Zytometrie und Automation in der klinischen Diagnostik. Beitr Onikol 38:298
4. Brown DC, Gatter K (1990) Monoclonal antibody Ki67: its use in histopathology. Histopathology 17:489-503
5. Chang F, Syrjanen S, Syrjanen K (1995) Implications of the p53 tumor-suppressor gene in clinical oncology. J Clin Oncol 13:1009
6. Crissman ID, Zarbo RI (1991) Quantitation of DNA ploidy in squamous intraepithelial neoplasia of the laryngeal glottis. Arch Otolaryngol Head Neck Surg 117
7. Dolcetti R, Doglioni C, Maestro R, Gasparotto D, Barzan L, Pastore A, Romanelli M, Boiocchi M (1992) p53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: genetic and prognostic implications. Int J Cancer 52:178-182
8. Eßer D, Meyer W, Willgeroth C, Motsch C (1994) Die Feststellung prognoserelevanter Faktoren bei Patienten mit einem Hypooder Oropharynxkarzinom. HNO 42:413-417
9. Field JK, Pavelic ZP, Spandidos DA, Stambrook PJ, Jones AS, Gluckman JL (1993) The role of the p53 tumour suppressor gene in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 119:1118-1122
10. Franzen G, Olofsson J, Klitenberg C, Bruuk K (1987) Prognostic value of malignancy grading and DNA measurments in small glottic carcinomas. ORL 49:73-80
11. Gerdes J, Lemke H, Baisch H, Wacker H-H, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715
12. Gluckman JL, Stambrook PJ, Pavelic ZP (1994) Letter. Prognostic significance of p53 protein accumulation in early stage T1 oral cavity cancer. Oral Oncol Eur J Cancer 4:281
13. Barona de Guzman ZZ, Mavtorek M, Basterra I, Armengot M, Montoro A, Montoro J (1993) Analysis of DNA content in supraglottic epidermoid carcinoma. Otolaryngol Head Neck Surg 10:706-710
14. Hong MK, Laskin WB, Herman BE, Johnston MH, Vargo JJ, Steinberg SM, Allegra CJ, Johnston PG (1995) Expansion of the Ki-67 proliferative compartment correlates with degree of dysplasia in Barrett's esophagus. Cancer 75:423-429
15. Kawai T, Suzuki M, Kono S, Kono S, Shinomiya, Rokutanda M, Takagi K, Ogata T, Tamai S (1994) Proliferating cell nuclear antigen and Ki-67 in lung carcinoma. Correlation with DNA flow cytometric analysis. Cancer 74:2468-2475
16. Kearsly JH, Furlong KL, Cooke RA, Waters MJ (1990) An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers. Br J Cancer 61:821-827
17. Lee NK, Ye Y-W, Chen J, Li X, Waber PG, Nisen PG (1993) p53, retinoblastoma and human papillomavirus in squamous cell carcinom and adjacent normal mucosa of the aerodigestive tract. Arch Otolaryngol Head Neck Surg 119:1125-1131
18. Lorz M, Meyer-Breiting E, Bettinger R (1994) Proliferating cell nuclear antigen counts as markers of cell proliferation in head and neck cancer. Eur Arch Otorhinolaryngeal 251:91-94
19. Löwenheim H (1997) Mokekularbiologie in der Onkologie von Kopf-Hals-Tumoren. HNO 4:185-186
20. Maestro R, Dolceti R, Gasparotto D, Doglioni C, Pelucchi S, Barzan L, Grandi E, Boicchi M (1992) High frequency of p53 gene alteration associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene 7:1159-1160
21. Munck-Wikland E, Fernberg JG, Kuylensterna R, Lindholm J, Auer G (1993) Proliferating cell nuclear antigen (PCNA) expression and nuclear DNA content in predicting recurrence after radiotherapy of early glottic cancer. Oral Oncol Eur J Cancer B 29:75-79
22. Munck-Wikland E, Edstrom S, Jungmark E, Kuylenstierna R, Lindholm J, Auer G (1994) Nuclear DNA content, proliferating-cell nuclear antigen (PCNA) and p53 immunostaining in predicting progression of laryngeal cancer in situ lesions. Int J Cancer 56:5-9
23. Nakanishi Y, Noguchi M, Matsuno Y, Saikawa M, Mukai K, Shimosato Y, Hirohashi S (1995) p53 expression in multicentric squamous cell carcinoma and surrounding squamous epithelium of the upper aerodigestive tract. Cancer 75:1657-1662
24. Nishioka H, Hiasa Y, Hayashi I, Kitahori Y, Konishi N, Sugimura M (1993) Immunohistochemical detection of p53 oncoprotein in human oral squamous cell carcinomas and leukoplakias: comparison with proliferating cell nuclear antigen staining and correlation with clinicopathological indings. Oncology 50:426-429
25. Nylander K, Stenling R, Gustafsson H, Zackrisson B, Roos G (1995) p53 expression and cell proliferation and squamous cell carcinomas of the head and neck. Cancer 75:87-93
26. Shall PA, Levison DA, Woods AL, Yu CC-W, Kellock DB, Watkins JA, Barnes DM, Gillett CE, Camplejohns R, Waseem NH, Lane DP (1990) Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evident of deregulated expression in some neoplasms. J Pathol 162:285-294
27. Shin DM, Kim J, Ro JY, Hittelmn J, Roth JA, Hong WK, Hittelman WN (1994) Activation of p53 gene expression in premalignant lesions during head and neck tumor-genesis. Cancer Res 54:321-326
28. Slootweg PJ, Koole R, Hordijk GT (1994) The presence of p53 protein in relation to Ki67 as cellular proliferation marker in head and neck squamous cell carcinoma and adjacent dysplastic mucosa. Oral Oncol Eur J Cancer 30:138-141
29. Soussi T, Legros Y, Lubin R, Ory K, Schlichtholz B (1994) Multifactorial analysis of p53 alteration in human cancer: a review. Int J Cancer 57:1-9
30. Storkel S, Reichert T, Reiffen KA, Wagner W (1993) EGFR and PCNA expression in oral squamous cell carcinomas - a valuable tool in estimating the patient's prognosis. Oral Oncol Eur J Cancer 29:273-277
31. Tomasino RM, Morello V, Bazan V, Nagar C, Tralongo V, Dardanoni G, Ingria F, Monteleone G, Restivo S, Nuara R, Daniele E, Russo A (1994) p53 expression in stage III-IV carcinoma of the larynx: an immunohistochemical study related to clinco pathological, flow-cytometric DNA analysis and prognosis. Int J Oncol 5:495-500
32. Truelson J, Fisher G, Beals T, McClathey K, Wolf G (1992) DNA content and histologic growth pattern correlate with prognosis in patients with advanced squamous cell carcinoma of the larynx. Cancer 70
33. Waseem N, Lane DP (1990) Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA).Structural concervation and the detection of a nucleolar form. J Cell Science 96:121-129